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PMID- 29324766
OWN - NLM
STAT- MEDLINE
DCOM- 20180206
LR  - 20180206
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 1
DP  - 2018
TI  - Liver transplantation for alcoholic hepatitis: A systematic review with
      meta-analysis.
PG  - e0190823
LID - 10.1371/journal.pone.0190823 [doi]
AB  - BACKGROUND: The rate of alcohol relapse among patients who underwent liver
      transplantation for alcoholic hepatitis (AH) is not precisely known. AIM:
      Synthesize the available evidence on liver transplantation for AH to assess
      alcohol relapse and 6-month survival. METHODS: Meta-analysis of trials evaluating
      liver transplantation for AH, either clinically severe or diagnosed on the
      explant. RESULTS: Eleven studies were included. The pooled estimate rate for
      alcohol relapse was 0.22 (95% CI = 0.12-0.36) in overall analysis with high
      heterogeneity between studies (I2 = 76%), 0.20 (95% CI = 0.07-0.43) in the
      subgroup analysis including patients with clinically severe AH (I2 = 84%), 0.14
      (95% CI = 0.08-0.23) among patients with clinically severe AH in sensitivity
      analysis excluding the discrepant studies that did not use stringent selection
      criteria for liver transplantation (I2 = 0%), and 0.15 (95% CI = 0.07-0.27) for
      recurrent harmful alcohol consumption among patients with clinically severe AH
      (I2 = 3%). The risk of alcohol relapse was not different between AH transplanted 
      patients and patients with alcoholic cirrhosis who underwent elective liver
      transplantation in sensitivity analysis excluding the discrepant studies (OR =
      1.68, 95%CI = 0.79-3.58, p = 0.2, I2 = 16%). The pooled estimate rate for 6-month
      survival was 0.85 (95% CI = 0.77-0.91, I2 = 49%), and 0.80 among patients
      transplanted for clinically severe AH (95% CI = 0.69-0.88, I2 = 30%). AH
      transplanted patients had similar 6-month survival to patients with alcoholic
      cirrhosis who underwent elective liver transplantation (OR = 2.00, 95% CI =
      0.95-4.23, p = 0.07, I2 = 0%). CONCLUSION: Using stringent selection criteria,
      14% of patients with clinically severe AH have alcohol relapse after liver
      transplantation. The percentage of alcohol relapse of AH transplanted patients is
      similar than that of patients who underwent elective liver transplantation.
FAU - Marot, Astrid
AU  - Marot A
AD  - Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire
      Vaudois, University of Lausanne, Lausanne, Switzerland.
FAU - Dubois, Margaux
AU  - Dubois M
AD  - Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire
      Vaudois, University of Lausanne, Lausanne, Switzerland.
FAU - Trepo, Eric
AU  - Trepo E
AD  - Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, CUB 
      Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium.
AD  - Laboratory of Experimental Gastroenterology, Universite Libre de Bruxelles,
      Brussels, Belgium.
FAU - Moreno, Christophe
AU  - Moreno C
AD  - Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, CUB 
      Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium.
AD  - Laboratory of Experimental Gastroenterology, Universite Libre de Bruxelles,
      Brussels, Belgium.
FAU - Deltenre, Pierre
AU  - Deltenre P
AUID- ORCID: 0000-0002-4253-6028
AD  - Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire
      Vaudois, University of Lausanne, Lausanne, Switzerland.
AD  - Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, CUB 
      Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20180111
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Alcohol Abstinence
MH  - Alcoholism/*complications
MH  - Elective Surgical Procedures
MH  - Hepatitis, Alcoholic/*surgery
MH  - Humans
MH  - *Liver Transplantation
MH  - Recurrence
PMC - PMC5764315
EDAT- 2018/01/13 06:00
MHDA- 2018/02/07 06:00
CRDT- 2018/01/12 06:00
PHST- 2017/08/28 00:00 [received]
PHST- 2017/12/20 00:00 [accepted]
PHST- 2018/01/12 06:00 [entrez]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/02/07 06:00 [medline]
AID - 10.1371/journal.pone.0190823 [doi]
AID - PONE-D-17-31567 [pii]
PST - epublish
SO  - PLoS One. 2018 Jan 11;13(1):e0190823. doi: 10.1371/journal.pone.0190823.
      eCollection 2018.