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Cognitive deficits and educational loss in children with schistosome infection-A systematic review and meta-analysis.

Abstract By means of meta-analysis of information from all relevant epidemiologic studies, we examined the hypothesis that Schistosoma infection in school-aged children (SAC) is associated with educational loss and cognitive deficits.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 29329293
OWN - NLM
STAT- In-Process
LR  - 20180114
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 12
IP  - 1
DP  - 2018 Jan
TI  - Cognitive deficits and educational loss in children with schistosome infection-A 
      systematic review and meta-analysis.
PG  - e0005524
LID - 10.1371/journal.pntd.0005524 [doi]
AB  - BACKGROUND: By means of meta-analysis of information from all relevant
      epidemiologic studies, we examined the hypothesis that Schistosoma infection in
      school-aged children (SAC) is associated with educational loss and cognitive
      deficits. METHODOLOGY/PRINCIPAL FINDINGS: This review was prospectively
      registered in the PROSPERO database (CRD42016040052). Medline, Biosis, and Web of
      Science were searched for studies published before August 2016 that evaluated
      associations between Schistosoma infection and cognitive or educational outcomes.
      Cognitive function was defined in four domains-learning, memory, reaction time,
      and innate intelligence. Educational outcome measures were defined as attendance 
      and scholastic achievement. Risk of bias (ROB) was evaluated using the
      Newcastle-Ottawa quality assessment scale. Standardized mean differences (SMD)
      and 95% confidence intervals (CI) were calculated to compare cognitive and
      educational measures for Schistosoma infected /not dewormed vs.
      uninfected/dewormed children. Sensitivity analyses by study design, ROB, and
      sequential exclusion of individual studies were implemented. Thirty studies from 
      14 countries, including 38,992 SAC between 5-19 years old, were identified.
      Compared to uninfected children and children dewormed with praziquantel, the
      presence of Schistosoma infection and/or non-dewormed status was associated with 
      deficits in school attendance (SMD = -0.36, 95%CI: -0.60, -0.12), scholastic
      achievement (SMD = -0.58, 95%CI: -0.96, -0.20), learning (SMD = -0.39, 95%CI:
      -0.70, -0.09) and memory (SMD = -0.28, 95%CI: -0.52, -0.04) tests. By contrast,
      Schistosoma-infected/non-dewormed and uninfected/dewormed children were similar
      with respect to performance in tests of reaction time (SMD = -0.06, 95%CI: -0.42,
      0.30) and intelligence (SMD = -0.25, 95%CI: -0.57, 0.06). Schistosoma
      infection-associated deficits in educational measures were robust among
      observational studies, but not among interventional studies. The significance of 
      infection-associated deficits in scholastic achievement was sensitive to ROB.
      Schistosoma infection-related deficits in learning and memory tests were
      invariant by ROB and study design. CONCLUSION/SIGNIFICANCE: Schistosoma
      infection/non-treatment was significantly associated with educational, learning, 
      and memory deficits in SAC. Early treatment of children in Schistosoma-endemic
      regions could potentially mitigate these deficits. TRIAL REGISTRATION:
      ClinicalTrials.gov CRD42016040052.
FAU - Ezeamama, Amara E
AU  - Ezeamama AE
AUID- ORCID: 0000-0003-2164-8802
AD  - Department of Psychiatry, College of Osteopathic Medicine, Michigan State
      University, East Lansing, Michigan, United States of America.
AD  - Department of Epidemiology & Biostatistics, University of Georgia, Athens,
      Georgia, United States of America.
FAU - Bustinduy, Amaya L
AU  - Bustinduy AL
AD  - Department of Clinical Research, London School of Hygiene and Tropical Medicine, 
      London, United Kingdom.
FAU - Nkwata, Allan K
AU  - Nkwata AK
AD  - Department of Epidemiology & Biostatistics, University of Georgia, Athens,
      Georgia, United States of America.
FAU - Martinez, Leonardo
AU  - Martinez L
AD  - Department of Epidemiology & Biostatistics, University of Georgia, Athens,
      Georgia, United States of America.
FAU - Pabalan, Noel
AU  - Pabalan N
AD  - Center for Research and Development, Angeles University Foundation, Angeles City,
      The Philippines.
FAU - Boivin, Michael J
AU  - Boivin MJ
AD  - Department of Psychiatry, College of Osteopathic Medicine, Michigan State
      University, East Lansing, Michigan, United States of America.
FAU - King, Charles H
AU  - King CH
AD  - Center for Global Health and Diseases, PAHO/WHO Collaborating Centre for Research
      and Training for Schistosomiasis Elimination, Case Western Reserve University
      School of Medicine, Cleveland, Ohio, United States of America.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180112
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
EDAT- 2018/01/13 06:00
MHDA- 2018/01/13 06:00
CRDT- 2018/01/13 06:00
PHST- 2016/10/15 00:00 [received]
PHST- 2017/03/23 00:00 [accepted]
PHST- 2018/01/13 06:00 [entrez]
PHST- 2018/01/13 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
AID - 10.1371/journal.pntd.0005524 [doi]
AID - PNTD-D-16-01885 [pii]
PST - epublish
SO  - PLoS Negl Trop Dis. 2018 Jan 12;12(1):e0005524. doi:
      10.1371/journal.pntd.0005524. eCollection 2018 Jan.