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Genetic basis of hearing loss in Spanish, Hispanic and Latino populations.

Abstract Hearing loss (HL) is the most common neurosensory disorder affecting humans. The screening, prevention and treatment of HL require a better understanding of the underlying molecular mechanisms. Genetic predisposition is one of the most common factors that leads to HL. Most HL studies include few Spanish, Hispanic and Latino participants, leaving a critical gap in our understanding about the prevalence, impact, unmet health care needs, and genetic factors associated with hearing impairment among Spanish, Hispanic and Latino populations. The few studies which have been performed show that the gene variants commonly associated with HL in non-Spanish and non-Hispanic populations are infrequently responsible for hearing impairment in Spanish as well as Hispanic and Latino populations (hereafter referred to as Hispanic). To design effective screening tools to detect HL in Spanish and Hispanic populations, studies must be conducted to determine the gene variants that are most commonly associated with hearing impairment in this racial/ethnic group. In this review article, we summarize gene variants and loci associated with HL in Spanish and Hispanic populations. Identifying new genetic variants associated with HL in Spanish and Hispanic populations will pave the way to develop effective screening tools and therapeutic strategies for HL.
PMID
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Authors

Mayor MeshTerms
Keywords

Genetic predisposition

Hearing loss

Hearing loss genes

Spanish population, Hispanic and Latino populations

Journal Title gene
Publication Year Start




PMID- 29331482
OWN - NLM
STAT- MEDLINE
DCOM- 20180209
LR  - 20180210
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 647
DP  - 2018 Mar 20
TI  - Genetic basis of hearing loss in Spanish, Hispanic and Latino populations.
PG  - 297-305
LID - S0378-1119(18)30034-9 [pii]
LID - 10.1016/j.gene.2018.01.027 [doi]
AB  - Hearing loss (HL) is the most common neurosensory disorder affecting humans. The 
      screening, prevention and treatment of HL require a better understanding of the
      underlying molecular mechanisms. Genetic predisposition is one of the most common
      factors that leads to HL. Most HL studies include few Spanish, Hispanic and
      Latino participants, leaving a critical gap in our understanding about the
      prevalence, impact, unmet health care needs, and genetic factors associated with 
      hearing impairment among Spanish, Hispanic and Latino populations. The few
      studies which have been performed show that the gene variants commonly associated
      with HL in non-Spanish and non-Hispanic populations are infrequently responsible 
      for hearing impairment in Spanish as well as Hispanic and Latino populations
      (hereafter referred to as Hispanic). To design effective screening tools to
      detect HL in Spanish and Hispanic populations, studies must be conducted to
      determine the gene variants that are most commonly associated with hearing
      impairment in this racial/ethnic group. In this review article, we summarize gene
      variants and loci associated with HL in Spanish and Hispanic populations.
      Identifying new genetic variants associated with HL in Spanish and Hispanic
      populations will pave the way to develop effective screening tools and
      therapeutic strategies for HL.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Mittal, Rahul
AU  - Mittal R
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA.
FAU - Patel, Amit P
AU  - Patel AP
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA.
FAU - Nguyen, Desiree
AU  - Nguyen D
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA.
FAU - Pan, Debbie R
AU  - Pan DR
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA.
FAU - Jhaveri, Vasanti M
AU  - Jhaveri VM
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA.
FAU - Rudman, Jason R
AU  - Rudman JR
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA.
FAU - Dharmaraja, Arjuna
AU  - Dharmaraja A
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA.
FAU - Yan, Denise
AU  - Yan D
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA.
FAU - Feng, Yong
AU  - Feng Y
AD  - Department of Otolaryngology, Xiangya Hospital, Central South University,
      Changsha, China.
FAU - Chapagain, Prem
AU  - Chapagain P
AD  - Department of Physics and Biomolecular Sciences Institute, Florida International 
      University, Miami, FL, USA.
FAU - Lee, David J
AU  - Lee DJ
AD  - Department of Public Health Sciences, University of Miami Miller School of
      Medicine, Miami, FL, USA.
FAU - Blanton, Susan H
AU  - Blanton SH
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA; Dr. John T. Macdonald Foundation Department of Human Genetics and
      John P. Hussman Institute for Human Genetics, University of Miami Miller School
      of Medicine, Miami, FL 33136, USA.
FAU - Liu, Xue Zhong
AU  - Liu XZ
AD  - Department of Otolaryngology, University of Miami Miller School of Medicine,
      Miami, FL, USA; Department of Otolaryngology, Xiangya Hospital, Central South
      University, Changsha, China; Tsinghua University School of Medicine, Beijing
      10084, China; Dr. John T. Macdonald Foundation Department of Human Genetics and
      John P. Hussman Institute for Human Genetics, University of Miami Miller School
      of Medicine, Miami, FL 33136, USA. Electronic address: [email protected]
LA  - eng
GR  - R01 DC005575/DC/NIDCD NIH HHS/United States
GR  - R01 DC012115/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20180110
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
SB  - IM
MH  - Animals
MH  - Deafness/genetics
MH  - Ethnic Groups/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Hearing Loss/*genetics
MH  - Hispanic Americans/*genetics
MH  - Humans
MH  - Prevalence
PMC - PMC5806531
MID - NIHMS935680
OTO - NOTNLM
OT  - Genetic predisposition
OT  - Hearing loss
OT  - Hearing loss genes
OT  - Spanish population, Hispanic and Latino populations
EDAT- 2018/01/15 06:00
MHDA- 2018/02/10 06:00
CRDT- 2018/01/15 06:00
PMCR- 2019/03/20 00:00
PHST- 2017/10/05 00:00 [received]
PHST- 2018/01/02 00:00 [revised]
PHST- 2018/01/06 00:00 [accepted]
PHST- 2019/03/20 00:00 [pmc-release]
PHST- 2018/01/15 06:00 [pubmed]
PHST- 2018/02/10 06:00 [medline]
PHST- 2018/01/15 06:00 [entrez]
AID - S0378-1119(18)30034-9 [pii]
AID - 10.1016/j.gene.2018.01.027 [doi]
PST - ppublish
SO  - Gene. 2018 Mar 20;647:297-305. doi: 10.1016/j.gene.2018.01.027. Epub 2018 Jan 10.