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Glecaprevir-Pibrentasvir for 8 or 12 Weeks in HCV Genotype 1 or 3 Infection.

Abstract Glecaprevir and pibrentasvir are direct-acting antiviral agents with pangenotypic activity and a high barrier to resistance. We evaluated the efficacy and safety of 8-week and 12-week courses of treatment with 300 mg of glecaprevir plus 120 mg of pibrentasvir in patients without cirrhosis who had hepatitis C virus (HCV) genotype 1 or 3 infection.
PMID
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Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis.

Authors

Mayor MeshTerms
Keywords
Journal Title the new england journal of medicine
Publication Year Start




PMID- 29365309
OWN - NLM
STAT- MEDLINE
DCOM- 20180208
LR  - 20180208
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 378
IP  - 4
DP  - 2018 Jan 25
TI  - Glecaprevir-Pibrentasvir for 8 or 12 Weeks in HCV Genotype 1 or 3 Infection.
PG  - 354-369
LID - 10.1056/NEJMoa1702417 [doi]
AB  - BACKGROUND: Glecaprevir and pibrentasvir are direct-acting antiviral agents with 
      pangenotypic activity and a high barrier to resistance. We evaluated the efficacy
      and safety of 8-week and 12-week courses of treatment with 300 mg of glecaprevir 
      plus 120 mg of pibrentasvir in patients without cirrhosis who had hepatitis C
      virus (HCV) genotype 1 or 3 infection. METHODS: We conducted two phase 3,
      randomized, open-label, multicenter trials. Patients with genotype 1 infection
      were randomly assigned in a 1:1 ratio to receive once-daily
      glecaprevir-pibrentasvir for either 8 or 12 weeks. Patients with genotype 3
      infection were randomly assigned in a 2:1 ratio to receive 12 weeks of treatment 
      with either glecaprevir-pibrentasvir or sofosbuvir-daclatasvir. Additional
      patients with genotype 3 infection were subsequently enrolled and nonrandomly
      assigned to receive 8 weeks of treatment with glecaprevir-pibrentasvir. The
      primary end point was the rate of sustained virologic response 12 weeks after the
      end of treatment. RESULTS: In total, 1208 patients were treated. The rate of
      sustained virologic response at 12 weeks among genotype 1-infected patients was
      99.1% (95% confidence interval [CI], 98 to 100) in the 8-week group and 99.7%
      (95% CI, 99 to 100) in the 12-week group. Genotype 3-infected patients who were
      treated for 12 weeks had a rate of sustained virologic response at 12 weeks of
      95% (95% CI, 93 to 98; 222 of 233 patients) with glecaprevir-pibrentasvir and 97%
      (95% CI, 93 to 99.9; 111 of 115) with sofosbuvir-daclatasvir; 8 weeks of
      treatment with glecaprevir-pibrentasvir yielded a rate of 95% (95% CI, 91 to 98; 
      149 of 157 patients). Adverse events led to discontinuation of treatment in no
      more than 1% of patients in any treatment group. CONCLUSIONS: Once-daily
      treatment with glecaprevir-pibrentasvir for either 8 weeks or 12 weeks achieved
      high rates of sustained virologic response among patients with HCV genotype 1 or 
      3 infection who did not have cirrhosis. (Funded by AbbVie; ENDURANCE-1 and
      ENDURANCE-3 ClinicalTrials.gov numbers, NCT02604017 and NCT02640157 .).
FAU - Zeuzem, Stefan
AU  - Zeuzem S
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Foster, Graham R
AU  - Foster GR
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Wang, Stanley
AU  - Wang S
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Asatryan, Armen
AU  - Asatryan A
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Gane, Edward
AU  - Gane E
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Feld, Jordan J
AU  - Feld JJ
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Asselah, Tarik
AU  - Asselah T
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Bourliere, Marc
AU  - Bourliere M
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Ruane, Peter J
AU  - Ruane PJ
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Wedemeyer, Heiner
AU  - Wedemeyer H
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Pol, Stanislas
AU  - Pol S
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Flisiak, Robert
AU  - Flisiak R
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Poordad, Fred
AU  - Poordad F
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Chuang, Wan-Long
AU  - Chuang WL
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Stedman, Catherine A
AU  - Stedman CA
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Flamm, Steven
AU  - Flamm S
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Kwo, Paul
AU  - Kwo P
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Dore, Gregory J
AU  - Dore GJ
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Sepulveda-Arzola, Gladys
AU  - Sepulveda-Arzola G
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Roberts, Stuart K
AU  - Roberts SK
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Soto-Malave, Ruth
AU  - Soto-Malave R
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Kaita, Kelly
AU  - Kaita K
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Puoti, Massimo
AU  - Puoti M
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Vierling, John
AU  - Vierling J
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Tam, Edward
AU  - Tam E
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Vargas, Hugo E
AU  - Vargas HE
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Bruck, Rafi
AU  - Bruck R
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Fuster, Francisco
AU  - Fuster F
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Paik, Seung-Woon
AU  - Paik SW
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Felizarta, Franco
AU  - Felizarta F
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Kort, Jens
AU  - Kort J
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Fu, Bo
AU  - Fu B
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Liu, Ran
AU  - Liu R
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Ng, Teresa I
AU  - Ng TI
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Pilot-Matias, Tami
AU  - Pilot-Matias T
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Lin, Chih-Wei
AU  - Lin CW
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Trinh, Roger
AU  - Trinh R
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
FAU - Mensa, Federico J
AU  - Mensa FJ
AD  - From Goethe University Hospital, Frankfurt (S.Z.), and Medizinische Hochschule
      Hannover, Hannover (H.W.) - both in Germany; Queen Mary University of London,
      Barts Health, London (G.R.F.); AbbVie, North Chicago (S.W., A.A., J.K., B.F.,
      R.L., T.I.N., T.P.-M., C.-W.L., R.T., F.J.M.), and Northwestern Feinberg School
      of Medicine, Chicago (S.F.) - both in Illinois; Liver Unit, Auckland City
      Hospital, Auckland (E.G.), and Christchurch Hospital and University of Otago,
      Christchurch (C.A.S.) - both in New Zealand; Toronto Centre for Liver Disease,
      University of Toronto, Toronto (J.J.F.), University of Manitoba, Winnipeg (K.K.),
      and LAIR Centre, Vancouver, BC (E.T.) - all in Canada; Centre de Recherche sur
      l'Inflammation, INSERM UMR 1149, Universite Paris Diderot, Service d'hepatologie,
      Assistance Publique-Hopitaux de Paris Hopital Beaujon, Clichy (T.A.), Hopital
      Saint Joseph, Marseille (M.B.), and Groupe Hospitalier Cochin-Saint Vincent de
      Paul, Paris (S.P.) - all in France; Ruane Medical and Liver Health Institute, Los
      Angeles (P.J.R.), Stanford University Division of Gastroenterology and
      Hepatology, Palo Alto (P.K.), and private practice, Bakersfield (F. Felizarta) - 
      all in California; Klinika Chorob Zakaznych i Hepatologii UM w Bialymstoku,
      Bialystok, Poland (R.F.); the Texas Liver Institute-University of Texas Health,
      San Antonio (F.P.), and Baylor College of Medicine, Houston (J.V.); Kaohsiung
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
      (W.-L.C.); Kirby Institute, University of New South Wales Sydney and St.
      Vincent's Hospital, Sydney (G.J.D.), and Alfred Hospital, Melbourne, VIC (S.K.R.)
      - both in Australia; Instituto de Investigacion Cientifica del Sur, Ponce
      (G.S.-A.), and University of Puerto Rico, San Juan (R.S.-M.) - both in Puerto
      Rico; Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan (M.P.); Mayo
      Clinic, Phoenix, AZ (H.E.V.); Tel Aviv Medical Center and Sackler Faculty of
      Medicine, Tel Aviv University, Tel Aviv, Israel (R.B.); Centro de Investigaciones
      Clinicas Vina del Mar, Vina del Mar, Chile (F. Fuster); and Samsung Medical
      Center, Seoul, South Korea (S.-W.P.).
LA  - eng
SI  - ClinicalTrials.gov/NCT02604017
SI  - ClinicalTrials.gov/NCT02640157
SI  - ClinicalTrials.gov/NCT02604017
SI  - ClinicalTrials.gov/NCT02640157
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (ABT-493)
RN  - 0 (Antiviral Agents)
RN  - 0 (BMS-790052)
RN  - 0 (Benzimidazoles)
RN  - 0 (Drug Combinations)
RN  - 0 (Imidazoles)
RN  - 0 (Quinoxalines)
RN  - 0 (RNA, Viral)
RN  - 0 (Sulfonamides)
RN  - 0 (pibrentasvir)
RN  - WJ6CA3ZU8B (Sofosbuvir)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antiviral Agents/adverse effects/*therapeutic use
MH  - Benzimidazoles/adverse effects/*therapeutic use
MH  - Drug Administration Schedule
MH  - Drug Combinations
MH  - Female
MH  - Genotype
MH  - Hepacivirus/*genetics
MH  - Hepatitis C, Chronic/*drug therapy/virology
MH  - Humans
MH  - Imidazoles/adverse effects/therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Quinoxalines/adverse effects/*therapeutic use
MH  - RNA, Viral/blood
MH  - Sofosbuvir/adverse effects/therapeutic use
MH  - Sulfonamides/adverse effects/*therapeutic use
MH  - Viral Load
EDAT- 2018/01/25 06:00
MHDA- 2018/02/09 06:00
CRDT- 2018/01/25 06:00
PHST- 2018/01/25 06:00 [entrez]
PHST- 2018/01/25 06:00 [pubmed]
PHST- 2018/02/09 06:00 [medline]
AID - 10.1056/NEJMoa1702417 [doi]
PST - ppublish
SO  - N Engl J Med. 2018 Jan 25;378(4):354-369. doi: 10.1056/NEJMoa1702417.