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Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age.

Abstract Obesity is a growing concern in horses. The effects of maternal obesity on maternal metabolism and low-grade inflammation during pregnancy, as well as offspring growth, metabolism, low-grade inflammation, testicular maturation and osteochondrotic lesions until 18 months of age were investigated.
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Mayor MeshTerms
Keywords
Journal Title plos one
Publication Year Start




PMID- 29373573
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20180205
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 1
DP  - 2018
TI  - Maternal obesity increases insulin resistance, low-grade inflammation and
      osteochondrosis lesions in foals and yearlings until 18 months of age.
PG  - e0190309
LID - 10.1371/journal.pone.0190309 [doi]
AB  - INTRODUCTION: Obesity is a growing concern in horses. The effects of maternal
      obesity on maternal metabolism and low-grade inflammation during pregnancy, as
      well as offspring growth, metabolism, low-grade inflammation, testicular
      maturation and osteochondrotic lesions until 18 months of age were investigated. 
      MATERIAL AND METHODS: Twenty-four mares were used and separated into two groups
      at insemination according to body condition score (BCS): Normal (N, n = 10, BCS
      </=4) and Obese (O, n = 14, BCS >/=4.25). BCS and plasma glucose, insulin,
      triglyceride, urea, non-esterified fatty acid, serum amyloid A (SAA), leptin and 
      adiponectin concentrations were monitored throughout gestation. At 300 days of
      gestation, a Frequently Sampled Intravenous Glucose Tolerance Test (FSIGT) was
      performed. After parturition, foals' weight and size were monitored until 18
      months of age with plasma SAA, leptin, adiponectin, triiodothyronine (T3),
      thyroxine (T4) and cortisol concentrations measured at regular intervals. At 6,
      12 and 18 months of age, FSIGT and osteoarticular examinations were performed.
      Males were gelded at one year and expression of genes involved in testicular
      maturation analysed by RT-qPCR. RESULTS: Throughout the experiment, maternal BCS 
      was higher in O versus N mares. During gestation, plasma urea and adiponectin
      were decreased and SAA and leptin increased in O versus N mares. O mares were
      also more insulin resistant than N mares with a higher glucose effectiveness.
      Postnatally, there was no difference in offspring growth between groups.
      Nevertheless, plasma SAA concentrations were increased in O versus N foals until 
      6 months, with O foals being consistently more insulin resistant with a higher
      glucose effectiveness. At 12 months of age, O foals were significantly more
      affected by osteochondrosis than N foals. All other parameters were not different
      between groups. CONCLUSION: In conclusion, maternal obesity altered metabolism
      and increased low-grade inflammation in both dams and foals. The risk of
      developing osteochondrosis at 12 months of age was also higher in foals born to
      obese dams.
FAU - Robles, M
AU  - Robles M
AUID- ORCID: 0000-0003-4821-4684
AD  - UMR BDR, INRA, ENVA, Universite Paris Saclay, Jouy en Josas, France.
FAU - Nouveau, E
AU  - Nouveau E
AD  - UMR BDR, INRA, ENVA, Universite Paris Saclay, Jouy en Josas, France.
FAU - Gautier, C
AU  - Gautier C
AD  - Normandie Univ, UNICAEN, EA2608, OeReCa, USC-INRA, Caen, France.
FAU - Mendoza, L
AU  - Mendoza L
AD  - Clinique Equine, Faculte de Medecine Veterinaire, Universite de Liege, Liege,
      Belgium.
FAU - Dubois, C
AU  - Dubois C
AD  - IFCE, Station Experimentale de la Valade, Chamberet, France.
FAU - Dahirel, M
AU  - Dahirel M
AD  - UMR BDR, INRA, ENVA, Universite Paris Saclay, Jouy en Josas, France.
FAU - Lagofun, B
AU  - Lagofun B
AD  - UMR BDR, INRA, ENVA, Universite Paris Saclay, Jouy en Josas, France.
FAU - Aubriere, M-C
AU  - Aubriere MC
AD  - UMR BDR, INRA, ENVA, Universite Paris Saclay, Jouy en Josas, France.
FAU - Lejeune, J-P
AU  - Lejeune JP
AD  - Clinique Equine, Faculte de Medecine Veterinaire, Universite de Liege, Liege,
      Belgium.
FAU - Caudron, I
AU  - Caudron I
AD  - Clinique Equine, Faculte de Medecine Veterinaire, Universite de Liege, Liege,
      Belgium.
FAU - Guenon, I
AU  - Guenon I
AD  - Normandie Univ, UNICAEN, EA2608, OeReCa, USC-INRA, Caen, France.
FAU - Viguie, C
AU  - Viguie C
AD  - INRA, UMR Toxalim, Research Center in Food Toxicology, Toulouse, France.
FAU - Wimel, L
AU  - Wimel L
AD  - IFCE, Station Experimentale de la Valade, Chamberet, France.
FAU - Bouraima-Lelong, H
AU  - Bouraima-Lelong H
AD  - Normandie Univ, UNICAEN, EA2608, OeReCa, USC-INRA, Caen, France.
FAU - Serteyn, D
AU  - Serteyn D
AD  - Clinique Equine, Faculte de Medecine Veterinaire, Universite de Liege, Liege,
      Belgium.
FAU - Couturier-Tarrade, A
AU  - Couturier-Tarrade A
AD  - UMR BDR, INRA, ENVA, Universite Paris Saclay, Jouy en Josas, France.
FAU - Chavatte-Palmer, P
AU  - Chavatte-Palmer P
AD  - UMR BDR, INRA, ENVA, Universite Paris Saclay, Jouy en Josas, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180126
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
SB  - IM
MH  - Adiponectin/blood
MH  - Animals
MH  - Animals, Newborn
MH  - Blood Glucose/metabolism
MH  - Female
MH  - Glucose Tolerance Test
MH  - Horse Diseases/*pathology/*physiopathology
MH  - Horses
MH  - Inflammation/etiology/*veterinary
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Leptin/blood
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - Obesity/complications/physiopathology/*veterinary
MH  - Osteochondrosis/etiology/*veterinary
MH  - Pregnancy
MH  - Pregnancy Complications/pathology/physiopathology/*veterinary
EDAT- 2018/01/27 06:00
MHDA- 2018/02/06 06:00
CRDT- 2018/01/27 06:00
PHST- 2017/08/28 00:00 [received]
PHST- 2017/12/12 00:00 [accepted]
PHST- 2018/01/27 06:00 [entrez]
PHST- 2018/01/27 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
AID - 10.1371/journal.pone.0190309 [doi]
AID - PONE-D-17-31615 [pii]
PST - epublish
SO  - PLoS One. 2018 Jan 26;13(1):e0190309. doi: 10.1371/journal.pone.0190309.
      eCollection 2018.