PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 29374693
OWN - NLM
STAT- MEDLINE
DCOM- 20180208
LR  - 20180208
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 2
DP  - 2018 Feb
TI  - Association of eIF4E and SPARC Expression with Lymphangiogenesis and Lymph Node
      Metastasis in Hypopharyngeal Cancer.
PG  - 699-706
AB  - BACKGROUND/AIM: Head and neck squamous cell carcinomas (HNSCC) are characterized 
      by aggressiveness, early recurrence and lymph node metastasis. Therefore, there
      is an urgent need to identify new biomarkers and drug targets. MATERIALS AND
      METHODS: Neck dissection specimens from 11 patients diagnosed with hypopharyngeal
      cancer were analyzed for their lymphatic vessel density (LVD) by lymphatic vessel
      endothelial hyaluronan receptor 1 (LYVE-1) immunostaining, expression of
      eukaryotic initiation factor 4E (eIF4E) and levels of secreted protein acidic and
      rich in cysteine (SPARC) using immunoblot analysis. RESULTS: Compared to lymph
      node biopsies of healthy controIs, LVD was significantly increased in metastatic 
      lymph nodes as well as in advanced primary tumors. Overexpression of eIF4E and
      SPARC was demonstrated in all hypopharyngeal cancer specimens. Notably, we
      observed that increased LVD significantly correlated with the expression of eIF4E
      as well as SPARC levels. CONCLUSION: eIF4E- and SPARC-associated signaling
      pathways may be associated with lymphangiogenesis and could be exploited to
      counteract the spread of hypopharyngeal cancer cells.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Ernst, Benjamin Philipp
AU  - Ernst BP
AD  - Department of Otorhinolaryngology, University Hospital Frankfurt, Frankfurt,
      Germany [email protected]
AD  - Department of Otorhinolaryngology, University Medical Center Mainz, Mainz,
      Germany.
FAU - Mikstas, Caja
AU  - Mikstas C
AD  - Department of Otorhinolaryngology, University Hospital Frankfurt, Frankfurt,
      Germany.
FAU - Stover, Timo
AU  - Stover T
AD  - Department of Otorhinolaryngology, University Hospital Frankfurt, Frankfurt,
      Germany.
FAU - Stauber, Roland
AU  - Stauber R
AD  - Department of Otorhinolaryngology, University Medical Center Mainz, Mainz,
      Germany.
FAU - Strieth, Sebastian
AU  - Strieth S
AD  - Department of Otorhinolaryngology, University Hospital Frankfurt, Frankfurt,
      Germany.
AD  - Department of Otorhinolaryngology, University Medical Center Mainz, Mainz,
      Germany.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (EIF4ENIF1 protein, human)
RN  - 0 (Nucleocytoplasmic Transport Proteins)
RN  - 0 (Osteonectin)
RN  - 0 (SPARC protein, human)
RN  - Carcinoma, squamous cell of head and neck
SB  - IM
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Squamous Cell/metabolism/pathology
MH  - Female
MH  - Head and Neck Neoplasms/metabolism/pathology
MH  - Humans
MH  - Hypopharyngeal Neoplasms/*metabolism/*pathology
MH  - Lymph Nodes/metabolism/pathology
MH  - Lymphangiogenesis/*physiology
MH  - Lymphatic Metastasis/pathology
MH  - Male
MH  - Middle Aged
MH  - Nucleocytoplasmic Transport Proteins/*metabolism
MH  - Osteonectin/*metabolism
OTO - NOTNLM
OT  - *Lymphangiogenesis
OT  - *SPARC
OT  - *eIF4E
OT  - *hypopharyngeal cancer
OT  - *metastasis
EDAT- 2018/01/29 06:00
MHDA- 2018/02/09 06:00
CRDT- 2018/01/29 06:00
PHST- 2017/10/31 00:00 [received]
PHST- 2017/12/10 00:00 [revised]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2018/01/29 06:00 [entrez]
PHST- 2018/01/29 06:00 [pubmed]
PHST- 2018/02/09 06:00 [medline]
AID - 38/2/699 [pii]
AID - 10.21873/anticanres.12275 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Feb;38(2):699-706. doi: 10.21873/anticanres.12275.