PubTransformer

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PMID- 29374727
OWN - NLM
STAT- In-Process
LR  - 20180201
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 2
DP  - 2018 Feb
TI  - The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma.
PG  - 955-962
AB  - BACKGROUND/AIM: This study evaluated the associations between bone invasion of
      gingival squamous cell carcinoma (SCC) and clinicopathological manifestations,
      and aimed to determine whether bone invasion is an independent prognostic factor 
      in gingival SCC. PATIENTS AND METHODS: The study was a retrospective review of 78
      patients with gingival SCC who underwent surgery with curative intent. The level 
      of bone invasion was pathologically categorized as medullary, cortical or no bone
      invasion. RESULTS: Cortical and medullary bone invasion was present in 29 and 22 
      patients, respectively. There was a significant association between medullary
      bone invasion and tumor size (p=0.017), pathological N classification (p<0.001), 
      differentiation (p=0.017) and lymphovascular invasion (p=0.007). Medullary bone
      invasion and lymphovascular invasion were independent predictors of reduced
      overall survival (p=0.015, 0.048); medullary bone invasion was also an
      independent predictor of reduced disease-specific survival (p=0.018). CONCLUSION:
      Pathologically-proven medullary bone invasion and lymphovascular invasion were
      found to be key prognostic factors in gingival SCC. The results suggest that it
      is necessary to consider adjuvant therapy in patients with medullary bone
      invasion.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Yoshida, Shoko
AU  - Yoshida S
AD  - Department of Oral and Maxillofacial Surgery, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Shimo, Tsuyoshi
AU  - Shimo T
AD  - Department of Oral and Maxillofacial Surgery, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
      [email protected]
FAU - Murase, Yurika
AU  - Murase Y
AD  - Department of Oral and Maxillofacial Surgery, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Takabatake, Kiyofumi
AU  - Takabatake K
AD  - Department of Oral Pathology and Medicine, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Kishimoto, Koji
AU  - Kishimoto K
AD  - Department of Oral and Maxillofacial Surgery, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Ibaragi, Soichiro
AU  - Ibaragi S
AD  - Department of Oral and Maxillofacial Surgery, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Yoshioka, Norie
AU  - Yoshioka N
AD  - Department of Oral and Maxillofacial Surgery, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Okui, Tatsuo
AU  - Okui T
AD  - Department of Oral and Maxillofacial Surgery, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Nagatsuka, Hitoshi
AU  - Nagatsuka H
AD  - Department of Oral Pathology and Medicine, Okayama University Graduate School of 
      Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Sasaki, Akira
AU  - Sasaki A
AD  - Department of Oral and Maxillofacial Surgery, Okayama University Graduate School 
      of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - *Gingival squamous cell carcinoma
OT  - *bone invasion
EDAT- 2018/01/29 06:00
MHDA- 2018/01/29 06:00
CRDT- 2018/01/29 06:00
PHST- 2017/10/27 00:00 [received]
PHST- 2017/11/23 00:00 [revised]
PHST- 2017/11/24 00:00 [accepted]
PHST- 2018/01/29 06:00 [entrez]
PHST- 2018/01/29 06:00 [pubmed]
PHST- 2018/01/29 06:00 [medline]
AID - 38/2/955 [pii]
AID - 10.21873/anticanres.12309 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Feb;38(2):955-962. doi: 10.21873/anticanres.12309.