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Analytical Methods for Quantification of Vitamin D and Implications for Research and Clinical Practice.

Abstract A plethora of contradictory research surrounds vitamin D and its influence on health and disease. This may, in part, result from analytical difficulties with regard to measuring vitamin D metabolites in serum. Indeed, variation exists between analytical techniques and assays used for the determination of serum 25-hydroxyvitamin D. Research studies into the effects of vitamin D on clinical endpoints rely heavily on the accurate assessment of vitamin D status. This has important implications, as findings from vitamin D-related studies to date may potentially have been hampered by the quantification techniques used. Likewise, healthcare professionals are increasingly incorporating vitamin D testing and supplementation regimens into their practice, and measurement errors may be also confounding the clinical decisions. Importantly, the Vitamin D Standardisation Programme is an initiative that aims to standardise the measurement of vitamin D metabolites. Such a programme is anticipated to eliminate the inaccuracies surrounding vitamin D quantification.
PMID
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Authors

Mayor MeshTerms
Keywords

25-hydroxyvitamin D

Epimer

Vitamin D Standardisation Programme

mass spectrometry

standardisation

Journal Title anticancer research
Publication Year Start




PMID- 29374750
OWN - NLM
STAT- In-Process
LR  - 20180201
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 2
DP  - 2018 Feb
TI  - Analytical Methods for Quantification of Vitamin D and Implications for Research 
      and Clinical Practice.
PG  - 1137-1144
AB  - A plethora of contradictory research surrounds vitamin D and its influence on
      health and disease. This may, in part, result from analytical difficulties with
      regard to measuring vitamin D metabolites in serum. Indeed, variation exists
      between analytical techniques and assays used for the determination of serum
      25-hydroxyvitamin D. Research studies into the effects of vitamin D on clinical
      endpoints rely heavily on the accurate assessment of vitamin D status. This has
      important implications, as findings from vitamin D-related studies to date may
      potentially have been hampered by the quantification techniques used. Likewise,
      healthcare professionals are increasingly incorporating vitamin D testing and
      supplementation regimens into their practice, and measurement errors may be also 
      confounding the clinical decisions. Importantly, the Vitamin D Standardisation
      Programme is an initiative that aims to standardise the measurement of vitamin D 
      metabolites. Such a programme is anticipated to eliminate the inaccuracies
      surrounding vitamin D quantification.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Stokes, Caroline S
AU  - Stokes CS
AD  - Department of Medicine II, Saarland University Medical Center, Saarland
      University, Homburg, Germany.
FAU - Lammert, Frank
AU  - Lammert F
AD  - Department of Medicine II, Saarland University Medical Center, Saarland
      University, Homburg, Germany.
FAU - Volmer, Dietrich A
AU  - Volmer DA
AD  - Institute of Bioanalytical Chemistry, Saarland University, Saarbrucken, Germany
      [email protected]
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - *25-hydroxyvitamin D
OT  - *Epimer
OT  - *Vitamin D Standardisation Programme
OT  - *mass spectrometry
OT  - *standardisation
EDAT- 2018/01/29 06:00
MHDA- 2018/01/29 06:00
CRDT- 2018/01/29 06:00
PHST- 2017/10/30 00:00 [received]
PHST- 2017/11/29 00:00 [revised]
PHST- 2017/11/30 00:00 [accepted]
PHST- 2018/01/29 06:00 [entrez]
PHST- 2018/01/29 06:00 [pubmed]
PHST- 2018/01/29 06:00 [medline]
AID - 38/2/1137 [pii]
AID - 10.21873/anticanres.12332 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Feb;38(2):1137-1144. doi: 10.21873/anticanres.12332.