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The Impact of UV-dose, Body Surface Area Exposed and Other Factors on Cutaneous Vitamin D Synthesis Measured as Serum 25(OH)D Concentration: Systematic Review and Meta-analysis.

Abstract To optimize public health campaigns concerning UV exposure, it is important to characterize factors that influence UV-induced cutaneous vitamin D production. This systematic review and meta-analysis investigated the impact of different individual and environmental factors including exposed body surface area (BSA), UVB dose and vitamin D status, on serum 25(OH)D concentration.
PMID
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Authors

Mayor MeshTerms
Keywords

UV dose

body surface area

meta-analysis

review

vitamin D

Journal Title anticancer research
Publication Year Start




PMID- 29374754
OWN - NLM
STAT- In-Process
LR  - 20180201
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 2
DP  - 2018 Feb
TI  - The Impact of UV-dose, Body Surface Area Exposed and Other Factors on Cutaneous
      Vitamin D Synthesis Measured as Serum 25(OH)D Concentration: Systematic Review
      and Meta-analysis.
PG  - 1165-1171
AB  - BACKGROUND/AIM: To optimize public health campaigns concerning UV exposure, it is
      important to characterize factors that influence UV-induced cutaneous vitamin D
      production. This systematic review and meta-analysis investigated the impact of
      different individual and environmental factors including exposed body surface
      area (BSA), UVB dose and vitamin D status, on serum 25(OH)D concentration.
      MATERIALS AND METHODS: In accordance with Preferred Reporting Items for
      Systematic Reviews and Meta-analyses, and Meta-analysis of Observational studies 
      in Epidemiology guidelines, a systematic literature search was conducted
      (MEDLINE; 01/1960-07/2016) investigating the impact of these factors on vitamin D
      status after artificial UV exposure as main outcome measure. Summary mean
      differences [and 95% confidence interval (CI)] were derived from random-effects
      meta-analysis to account for possible heterogeneity across studies.
      Meta-regression was conducted to account for impact of UVB dose, baseline 25(OH)D
      level and BSA. RESULTS: We identified 15 studies, with an estimated mean 25(OH)D 
      rise per standard erythema dose (SED) of 0.19 nmol/l (95% CI 0.11-0.26 nmol/l).
      Results from meta-regression suggest a significant impact of UV dose and baseline
      25(OH)D concentration on serum 25(OH)D level (p<0.01). Single UVB doses between
      0.75 and 3 SED resulted in the highest rise of serum 25(OH)D per dose unit. BSA
      exposed had a smaller, non-proportional, not significant impact. Partial BSA
      exposure resulted in relatively higher rise compared to whole-body exposure (e.g.
      exposure of face and hands caused an 8-fold higher rise of serum 25(OH)D
      concentration/SED/1% BSA compared to whole-body exposure). Our findings support
      previous reports, estimating that the half-life of serum 25(OH)D varies depending
      on different factors. CONCLUSION: Our results indicate that partial BSA exposure 
      (e.g. 10%) with moderate UV doses (e.g. 1 SED) is effective in generating or
      maintaining a healthy vitamin D status. However, due to limitations that include 
      possible confounding factors such as skin type, which could not be considered,
      these findings should be interpreted with caution.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Jager, Nadine
AU  - Jager N
AD  - Center for Clinical and Experimental Photodermatology, The Saarland University
      Hospital, Homburg, Germany.
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
FAU - Schope, Jakob
AU  - Schope J
AD  - Center for Clinical and Experimental Photodermatology, The Saarland University
      Hospital, Homburg, Germany.
AD  - Institute for Medical Biometry, Epidemiology and Medical Informatics, Saarland
      University, Homburg, Germany.
FAU - Wagenpfeil, Stefan
AU  - Wagenpfeil S
AD  - Center for Clinical and Experimental Photodermatology, The Saarland University
      Hospital, Homburg, Germany.
AD  - Institute for Medical Biometry, Epidemiology and Medical Informatics, Saarland
      University, Homburg, Germany.
FAU - Bocionek, Peter
AU  - Bocionek P
AD  - Jorg Wolff Foundation, Stuttgart, Germany.
FAU - Saternus, Roman
AU  - Saternus R
AD  - Center for Clinical and Experimental Photodermatology, The Saarland University
      Hospital, Homburg, Germany.
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
FAU - Vogt, Thomas
AU  - Vogt T
AD  - Center for Clinical and Experimental Photodermatology, The Saarland University
      Hospital, Homburg, Germany.
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
FAU - Reichrath, Jorg
AU  - Reichrath J
AD  - Center for Clinical and Experimental Photodermatology, The Saarland University
      Hospital, Homburg, Germany [email protected]
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - *UV dose
OT  - *body surface area
OT  - *meta-analysis
OT  - *review
OT  - *vitamin D
EDAT- 2018/01/29 06:00
MHDA- 2018/01/29 06:00
CRDT- 2018/01/29 06:00
PHST- 2017/11/01 00:00 [received]
PHST- 2017/12/14 00:00 [revised]
PHST- 2017/12/18 00:00 [accepted]
PHST- 2018/01/29 06:00 [entrez]
PHST- 2018/01/29 06:00 [pubmed]
PHST- 2018/01/29 06:00 [medline]
AID - 38/2/1165 [pii]
AID - 10.21873/anticanres.12336 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Feb;38(2):1165-1171. doi: 10.21873/anticanres.12336.