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Solarium Use and Risk for Malignant Melanoma: Meta-analysis and Evidence-based Medicine Systematic Review.

Abstract There is an ongoing debate whether solarium use (indoor tanning/artificial UV) may increase the risk for primary cutaneous malignant melanoma.
PMID
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Authors

Mayor MeshTerms
Keywords

Malignant melanoma

UV

review

solarium

Journal Title anticancer research
Publication Year Start




PMID- 29374757
OWN - NLM
STAT- In-Process
LR  - 20180201
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 2
DP  - 2018 Feb
TI  - Solarium Use and Risk for Malignant Melanoma: Meta-analysis and Evidence-based
      Medicine Systematic Review.
PG  - 1187-1199
AB  - BACKGROUND: There is an ongoing debate whether solarium use (indoor
      tanning/artificial UV) may increase the risk for primary cutaneous malignant
      melanoma. AIM: A systematic literature search was conducted using MEDLINE and ISI
      Web of Science. Included studies were critically assessed regarding their risk of
      bias, and methodological shortcomings. Levels of evidence and grades of
      recommendation were determined according to guidelines of the Oxford Centre for
      Evidence-Based Medicine. Summary risk estimates and 95% confidence intervals for 
      four different outcomes (ever exposure, exposure at younger age, high/low
      exposure vs. non-exposure) were derived from random-effects meta-analyses to
      account for possible heterogeneity across studies. RESULTS: Two cohort and
      twenty-nine case-control studies were eligible. Overall, quality of included
      studies was poor as a result of severe limitations, including possible recall and
      selection bias, and due to lack of interventional trials. Summary risk estimates 
      suggested a weak association (odds ratio (OR)=1.19, 95% confidence interval
      (CI)=1.04-1.35, p=0.009) for ever-exposure to UV radiation from a solarium with
      melanoma risk. However, sensitivity analyses did not show an association for
      studies from Europe (OR=1.10; 95%CI=0.95-1.27, p=0.218), studies with low risk of
      bias (OR=1.15; 95%CI=0.94-1.41, p=0.179), and studies conducted after 1990 (OR
      1.09; 95%CI=0.93-1.29, p=0.295). Moreover, moderate associations were found for
      first exposure to UV radiation from a solarium at younger age (<25 years) and
      high exposure (>10 sessions in lifetime) with melanoma risk. However, for all
      outcomes analyzed, overall study quality and resulting levels of evidence (3a-)
      and grades of recommendation (D) were low due to lack of interventional studies
      and severe limitations including unobserved or unrecorded confounding.
      CONCLUSION: Current scientific knowledge is mainly based on observational studies
      with poor quality data, which report associations but do not prove causality. At 
      present, there is no convincing evidence that moderate/responsible solarium use
      increases melanoma risk.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Burgard, Barbara
AU  - Burgard B
AD  - Center for Clinical and Experimental Photodermatology, Saarland University,
      Campus Homburg, Homburg, Germany.
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
FAU - Schope, Jakob
AU  - Schope J
AD  - Center for Clinical and Experimental Photodermatology, Saarland University,
      Campus Homburg, Homburg, Germany.
AD  - Institute for Medical Biometry, Epidemiology and Medical Informatics, Saarland
      University, Campus Homburg, Homburg, Germany.
FAU - Holzschuh, Isabel
AU  - Holzschuh I
AD  - Center for Clinical and Experimental Photodermatology, Saarland University,
      Campus Homburg, Homburg, Germany.
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
FAU - Schiekofer, Claudia
AU  - Schiekofer C
AD  - Center for Clinical and Experimental Photodermatology, Saarland University,
      Campus Homburg, Homburg, Germany.
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
FAU - Reichrath, Sandra
AU  - Reichrath S
AD  - Center for Clinical and Experimental Photodermatology, Saarland University,
      Campus Homburg, Homburg, Germany.
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
FAU - Stefan, Wagenpfeil
AU  - Stefan W
AD  - Center for Clinical and Experimental Photodermatology, Saarland University,
      Campus Homburg, Homburg, Germany.
AD  - Institute for Medical Biometry, Epidemiology and Medical Informatics, Saarland
      University, Campus Homburg, Homburg, Germany.
FAU - Pilz, Stefan
AU  - Pilz S
AD  - Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care 
      Research, VU University Medical Center, Amsterdam, the Netherlands.
AD  - Department of Internal Medicine, Division of Endocrinology and Metabolism,
      Medical University of Graz, Graz, Austria.
FAU - Ordonez-Mena, Jose
AU  - Ordonez-Mena J
AD  - Division of Clinical Epidemiology and Aging Research, German Cancer Research
      Center (DKFZ), Heidelberg, Germany.
AD  - Network Aging Research (NAR), Heidelberg University, Heidelberg, Germany.
AD  - Nuffield Department of Primary Care Health Sciences, University of Oxford,
      Oxford, U.K.
FAU - Marz, Winfried
AU  - Marz W
AD  - Medical Clinic V (Nephrology, Hypertensiology, Rheumatology, Endocrinology,
      Diabetology), Medical Faculty Mannheim, Ruperto-Carola University of Heidelberg, 
      Heidelberg, Germany.
AD  - Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical
      University of Graz, Graz, Austria.
AD  - Synlab Medical Center of Human Genetics Mannheim, Mannheim, Germany.
FAU - Vogt, Thomas
AU  - Vogt T
AD  - Center for Clinical and Experimental Photodermatology, Saarland University,
      Campus Homburg, Homburg, Germany.
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
FAU - Reichrath, Jorg
AU  - Reichrath J
AD  - Center for Clinical and Experimental Photodermatology, Saarland University,
      Campus Homburg, Homburg, Germany [email protected]
AD  - Department of Dermatology, The Saarland University Hospital, Homburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
OTO - NOTNLM
OT  - *Malignant melanoma
OT  - *UV
OT  - *review
OT  - *solarium
EDAT- 2018/01/29 06:00
MHDA- 2018/01/29 06:00
CRDT- 2018/01/29 06:00
PHST- 2017/10/31 00:00 [received]
PHST- 2017/12/13 00:00 [revised]
PHST- 2017/12/29 00:00 [accepted]
PHST- 2018/01/29 06:00 [entrez]
PHST- 2018/01/29 06:00 [pubmed]
PHST- 2018/01/29 06:00 [medline]
AID - 38/2/1187 [pii]
AID - 10.21873/anticanres.12339 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Feb;38(2):1187-1199. doi: 10.21873/anticanres.12339.