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Chronic autoimmune disorders are increased in coeliac disease: A case-control study.

Abstract Coeliac disease (CD) is an autoimmune disorder of the small bowel associated with increased risk of additional autoimmune diseases (ADs).To investigate the prevalence of ADs in a population of adult coeliac patients.This was a retrospective case-control study. Data from coeliac patients and controls referred to a tertiary center between 2013 and 2016 were collected. The frequency of ADs and the unadjusted and adjusted odds ratios (ORs) for age, gender, disease duration, and body mass index with their 95% confidence intervals (CIs) were evaluated.Two hundred fifty-five patients with CD (median age 37.1 years; 206 women) were matched with 250 controls. ADs were more frequent (35.3%) in coeliac patients than in controls (15.2%). Adjusted ORs for the presence of only 1, at least 1, and more than 1 AD were 3.13 (95% CI 1.81-5.42, P < .0001), 3.31 (95% CI 2.00-5.46, P < .0001), and 3.93 (95% CI 1.49-10.36, P = .006), respectively. Hashimoto thyroiditis was the most prevalent AD (24.3% vs. 10%) OR = 2.55 (95% CI 1.39-4.70, P < .0001), followed by psoriasis (4.3% vs. 1.6%), type 1 diabetes (2.7% vs. 0.4%), and Sjögren syndrome (2.4% vs. 0.4%).These findings suggest a need for a careful surveillance of autoimmune status, especially for Hashimoto thyroiditis in patients with celiac disease.
PMID
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Authors

Mayor MeshTerms

Autoimmune Diseases

Celiac Disease

Hashimoto Disease

Keywords
Journal Title medicine
Publication Year Start




PMID- 29381930
OWN - NLM
STAT- MEDLINE
DCOM- 20180208
LR  - 20180208
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 47
DP  - 2017 Nov
TI  - Chronic autoimmune disorders are increased in coeliac disease: A case-control
      study.
PG  - e8562
LID - 10.1097/MD.0000000000008562 [doi]
AB  - Coeliac disease (CD) is an autoimmune disorder of the small bowel associated with
      increased risk of additional autoimmune diseases (ADs).To investigate the
      prevalence of ADs in a population of adult coeliac patients.This was a
      retrospective case-control study. Data from coeliac patients and controls
      referred to a tertiary center between 2013 and 2016 were collected. The frequency
      of ADs and the unadjusted and adjusted odds ratios (ORs) for age, gender, disease
      duration, and body mass index with their 95% confidence intervals (CIs) were
      evaluated.Two hundred fifty-five patients with CD (median age 37.1 years; 206
      women) were matched with 250 controls. ADs were more frequent (35.3%) in coeliac 
      patients than in controls (15.2%). Adjusted ORs for the presence of only 1, at
      least 1, and more than 1 AD were 3.13 (95% CI 1.81-5.42, P &lt; .0001), 3.31 (95% CI
      2.00-5.46, P &lt; .0001), and 3.93 (95% CI 1.49-10.36, P = .006), respectively.
      Hashimoto thyroiditis was the most prevalent AD (24.3% vs. 10%) OR = 2.55 (95% CI
      1.39-4.70, P &lt; .0001), followed by psoriasis (4.3% vs. 1.6%), type 1 diabetes
      (2.7% vs. 0.4%), and Sjogren syndrome (2.4% vs. 0.4%).These findings suggest a
      need for a careful surveillance of autoimmune status, especially for Hashimoto
      thyroiditis in patients with celiac disease.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Bibbo, Stefano
AU  - Bibbo S
AD  - Department of Clinical and Experimental Medicine, University of Sassari, Sassari.
FAU - Pes, Giovanni Mario
AU  - Pes GM
AD  - Department of Clinical and Experimental Medicine, University of Sassari, Sassari.
FAU - Usai-Satta, Paolo
AU  - Usai-Satta P
AD  - Gastroenterology Unit, Brotzu Hospital, Cagliari, Italy.
FAU - Salis, Roberta
AU  - Salis R
AD  - Department of Clinical and Experimental Medicine, University of Sassari, Sassari.
FAU - Soro, Sara
AU  - Soro S
AD  - Department of Clinical and Experimental Medicine, University of Sassari, Sassari.
FAU - Quarta Colosso, Bianca Maria
AU  - Quarta Colosso BM
AD  - Department of Clinical and Experimental Medicine, University of Sassari, Sassari.
FAU - Dore, Maria Pina
AU  - Dore MP
AD  - Department of Clinical and Experimental Medicine, University of Sassari, Sassari.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - *Autoimmune Diseases/diagnosis/epidemiology/immunology
MH  - Autoimmunity/immunology
MH  - Case-Control Studies
MH  - *Celiac Disease/diagnosis/epidemiology/immunology
MH  - Female
MH  - *Hashimoto Disease/diagnosis/epidemiology/immunology
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Prevalence
MH  - Retrospective Studies
PMC - PMC5708929
EDAT- 2018/02/01 06:00
MHDA- 2018/02/09 06:00
CRDT- 2018/02/01 06:00
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/02/09 06:00 [medline]
AID - 10.1097/MD.0000000000008562 [doi]
AID - 00005792-201711270-00021 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Nov;96(47):e8562. doi: 10.1097/MD.0000000000008562.