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Latent scurvy with tiredness and leg pain in alcoholics: An underestimated disease three case reports.

Abstract Scurvy is often diagnosed at the state of well-established signs as, for example, skin and visceral purpura, gums involvement, loss of healthy teeth, which derive mostly from disturbance of collagen metabolism. Little is known about the state of latent scurvy, which symptoms are nonspecific and may mimic more common conditions such as weakness, leg pain, and muscle aching.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29382002
OWN - NLM
STAT- MEDLINE
DCOM- 20180209
LR  - 20180209
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 47
DP  - 2017 Nov
TI  - Latent scurvy with tiredness and leg pain in alcoholics: An underestimated
      disease three case reports.
PG  - e8861
LID - 10.1097/MD.0000000000008861 [doi]
AB  - RATIONALE: Scurvy is often diagnosed at the state of well-established signs as,
      for example, skin and visceral purpura, gums involvement, loss of healthy teeth, 
      which derive mostly from disturbance of collagen metabolism. Little is known
      about the state of latent scurvy, which symptoms are nonspecific and may mimic
      more common conditions such as weakness, leg pain, and muscle aching. PATIENT
      CONCERNS: We report 3 cases of extreme lassitude and leg pain in alcoholics. In 2
      of the 3 cases, discreet classic symptoms such as petechiae or hyperkeratosis of 
      the legs involving collagen metabolism were also present. DIAGNOSES: Latent
      scurvy has been diagnosed thanks to historical experimental data reporting and
      undetectable ascorbic acid levels. INTERVENTIONS: In addition to the treatments
      recommended by the French Alcohol Society, patients were given oral vitamin C 500
      mg to 1000 mg per day for at least three months. OUTCOMES: Vitamin C
      supplementation allowed the regression of the symptoms, greatly improved the
      quality of life, and gave the possibility to return to work. Cartinine, requiring
      vitamin C for its hydroxylation, is an essential cofactor in the transport of
      long-chain fatty acid into mitochondrial matrix. Therefore, it plays an important
      role in energy production via beta-oxidation. It is thought that carnitine
      metabolism impairment is responsible for weakness or muscle aching. LESSONS: We
      recommend being aware of the possibility of latent scurvy in chronic alcohol
      abusers. The vitamin C supplementation and dietetic recommendation eating fresh
      fruit and vegetables may help to cure tiredness and to return more easily to
      socialization and to work.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Lux-Battistelli, Christine
AU  - Lux-Battistelli C
FAU - Battistelli, Daniel
AU  - Battistelli D
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Vitamins)
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Alcoholism/*complications
MH  - Ascorbic Acid/administration & dosage
MH  - Dietary Supplements
MH  - Fatigue/*etiology/therapy
MH  - Humans
MH  - Leg
MH  - Male
MH  - Middle Aged
MH  - Myalgia/*etiology/therapy
MH  - Scurvy/*etiology/therapy
MH  - Vitamins/administration & dosage
PMC - PMC5709001
EDAT- 2018/02/01 06:00
MHDA- 2018/02/10 06:00
CRDT- 2018/02/01 06:00
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/02/10 06:00 [medline]
AID - 10.1097/MD.0000000000008861 [doi]
AID - 00005792-201711270-00093 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Nov;96(47):e8861. doi: 10.1097/MD.0000000000008861.