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Identifying protein biomarkers in predicting disease severity of dengue virus infection using immune-related protein microarray.

Abstract Dengue virus is one of the most widespread flaviviruses that re-emerged throughout recent decades. The progression from mild dengue to severe dengue (SD) with the complications such as vascular leakage and hemorrhage increases the fatality rate of dengue. The pathophysiology of SD is not entirely clear. To investigate potential biomarkers that are suggestive of pathogenesis of SD, a small panel of serum samples selected from 1 healthy individual, 2 dengue patients without warning signs (DWS-), 2 dengue patients with warning signs (DWS+), and 5 patients with SD were subjected to a pilot analysis using Sengenics Immunome protein array. The overall fold changes of protein expressions and clustering heat map revealed that PFKFB4, TPM1, PDCL3, and PTPN20A were elevated among patients with SD. Differential expression analysis identified that 29 proteins were differentially elevated greater than 2-fold in SD groups than DWS- and DWS+. From the 29 candidate proteins, pathways enrichment analysis also identified insulin signaling and cytoskeleton pathways were involved in SD, suggesting that the insulin pathway may play a pivotal role in the pathogenesis of SD.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29384851
OWN - NLM
STAT- In-Process
LR  - 20180131
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 5
DP  - 2018 Feb
TI  - Identifying protein biomarkers in predicting disease severity of dengue virus
      infection using immune-related protein microarray.
PG  - e9713
LID - 10.1097/MD.0000000000009713 [doi]
AB  - Dengue virus is one of the most widespread flaviviruses that re-emerged
      throughout recent decades. The progression from mild dengue to severe dengue (SD)
      with the complications such as vascular leakage and hemorrhage increases the
      fatality rate of dengue. The pathophysiology of SD is not entirely clear. To
      investigate potential biomarkers that are suggestive of pathogenesis of SD, a
      small panel of serum samples selected from 1 healthy individual, 2 dengue
      patients without warning signs (DWS-), 2 dengue patients with warning signs
      (DWS+), and 5 patients with SD were subjected to a pilot analysis using Sengenics
      Immunome protein array. The overall fold changes of protein expressions and
      clustering heat map revealed that PFKFB4, TPM1, PDCL3, and PTPN20A were elevated 
      among patients with SD. Differential expression analysis identified that 29
      proteins were differentially elevated greater than 2-fold in SD groups than DWS- 
      and DWS+. From the 29 candidate proteins, pathways enrichment analysis also
      identified insulin signaling and cytoskeleton pathways were involved in SD,
      suggesting that the insulin pathway may play a pivotal role in the pathogenesis
      of SD.
FAU - Soe, Hui Jen
AU  - Soe HJ
AD  - Department of Medical Microbiology.
FAU - Yong, Yean K
AU  - Yong YK
AD  - Laboratory Centre, Xiamen University Malaysia, China-ASEAN College of Marine
      Biotechnology, Sepang, Selangor.
FAU - Al-Obaidi, Mazen M Jamil
AU  - Al-Obaidi MMJ
AD  - Department of Medical Microbiology.
FAU - Raju, Chandramathi Samudi
AU  - Raju CS
AD  - Department of Medical Microbiology.
FAU - Gudimella, Ranganath
AU  - Gudimella R
AD  - Sengenics Corporation, HIR Building, University Malaya 50603 Kuala Lumpur,
      Malaysia.
FAU - Manikam, Rishya
AU  - Manikam R
AD  - Department of Trauma and Emergency, Faculty of Medicine, University of Malaya.
FAU - Sekaran, Shamala Devi
AU  - Sekaran SD
AD  - Faculty of Medicine, MAHSA University, Bandar Saujana Putra.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2018/02/01 06:00
MHDA- 2018/02/01 06:00
CRDT- 2018/02/01 06:00
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
AID - 10.1097/MD.0000000000009713 [doi]
AID - 00005792-201802020-00013 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Feb;97(5):e9713. doi: 10.1097/MD.0000000000009713.