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Myocardial perfusion at rest in uncomplicated type 2 diabetes patients without coronary artery disease evaluated by 320-multidetector computed tomography: A pilot study.

Abstract Using computed tomography myocardial perfusion imaging (CTP) to investigate resting myocardial perfusion alterations in uncomplicated type 2 diabetes mellitus (T2DM) patients without obstructive coronary artery disease (CAD).A total of 34 participants with 544 myocardial segments were included prospectively: 17 uncomplicated T2DM patients with no significant coronary artery stenosis on coronary computed tomography angiography and 17 healthy controls. Myocardial perfusion was evaluated by transmural perfusion ratio (TPR). Parameters of cardiac structure and function were measured for cardiac comprehensive assessment. Analyses included descriptive statistics and group comparisons.TPR of segments 5, 7, 9, 10 to 14 were significantly reduced in T2DM group compared with controls (P < .05). When 16 myocardial segments were localized into different areas according to the wall orientations, axial levels of left ventricle and coronary artery territories, respectively, TPR of each area in T2DM group were significantly lower than those in the control group (P < .05). No significant differences were found in cardiac anatomy and function analyses between 2 groups.In uncomplicated T2DM patients without obstructive CAD, myocardial perfusion impairments were present and may develop prior to cardiac morphological and functional abnormalities, which can be early detected by CTP.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29384863
OWN - NLM
STAT- In-Process
LR  - 20180131
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 5
DP  - 2018 Feb
TI  - Myocardial perfusion at rest in uncomplicated type 2 diabetes patients without
      coronary artery disease evaluated by 320-multidetector computed tomography: A
      pilot study.
PG  - e9762
LID - 10.1097/MD.0000000000009762 [doi]
AB  - Using computed tomography myocardial perfusion imaging (CTP) to investigate
      resting myocardial perfusion alterations in uncomplicated type 2 diabetes
      mellitus (T2DM) patients without obstructive coronary artery disease (CAD).A
      total of 34 participants with 544 myocardial segments were included
      prospectively: 17 uncomplicated T2DM patients with no significant coronary artery
      stenosis on coronary computed tomography angiography and 17 healthy controls.
      Myocardial perfusion was evaluated by transmural perfusion ratio (TPR).
      Parameters of cardiac structure and function were measured for cardiac
      comprehensive assessment. Analyses included descriptive statistics and group
      comparisons.TPR of segments 5, 7, 9, 10 to 14 were significantly reduced in T2DM 
      group compared with controls (P &lt; .05). When 16 myocardial segments were
      localized into different areas according to the wall orientations, axial levels
      of left ventricle and coronary artery territories, respectively, TPR of each area
      in T2DM group were significantly lower than those in the control group (P &lt; .05).
      No significant differences were found in cardiac anatomy and function analyses
      between 2 groups.In uncomplicated T2DM patients without obstructive CAD,
      myocardial perfusion impairments were present and may develop prior to cardiac
      morphological and functional abnormalities, which can be early detected by CTP.
FAU - Cai, Xiangyi
AU  - Cai X
AD  - Medical Imaging Center, First Affiliated Hospital of Jinan University.
FAU - Zhang, Shuihua
AU  - Zhang S
AD  - Medical Imaging Center, First Affiliated Hospital of Jinan University.
FAU - Deng, Dabiao
AU  - Deng D
AD  - Department of Radiology, Guangdong 999 Brain Hospital, Guangzhou, Guangdong,
      China.
FAU - Li, Honglin
AU  - Li H
AD  - Medical Imaging Center, First Affiliated Hospital of Jinan University.
FAU - Guan, Xueqing
AU  - Guan X
AD  - Medical Imaging Center, First Affiliated Hospital of Jinan University.
FAU - Fang, Jin
AU  - Fang J
AD  - Medical Imaging Center, First Affiliated Hospital of Jinan University.
FAU - Zhou, Quan
AU  - Zhou Q
AD  - Medical Imaging Center, First Affiliated Hospital of Jinan University.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2018/02/01 06:00
MHDA- 2018/02/01 06:00
CRDT- 2018/02/01 06:00
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
AID - 10.1097/MD.0000000000009762 [doi]
AID - 00005792-201802020-00025 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Feb;97(5):e9762. doi: 10.1097/MD.0000000000009762.