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Risk factors for heart valve calcification in chronic kidney disease.

Abstract Cardiovascular disease (CVD) is a common cause of death in patients with chronic kidney disease (CKD). Aortic and mitral valve calcification (AVC and MVC, respectively) are critical indicators of CVD and all-cause mortality in CKD patients.We conducted a single center retrospective study of Chinese inpatients with CKD to identify risk factors associated with valve calcification (VC).Of 288 enrolled CKD patients, 22.9% had VC, all of which exhibited AVC, while 21.2% exhibited MVC. The VC group were significantly older than the non-VC group (70.42 ± 11.83 vs 56.47 ± 15.00, P < .001), and contained more patients with history of coronary artery disease (12.1% vs 4.5%, P = .025) or stroke (18.2% vs 5.4%, P < .001). Subjective global assessment scoring indicated that more VC patients were mid/severely malnourished. Levels of prealbumin, cholesterol (Ch), triglycerides, low-density lipoprotein (LDL), apolipoprotein E, ejection fraction, and fraction shortening were significantly lower, and blood C reactive protein, IL-6, left ventricular internal end diastole diameter measured in end diastole, and interventricular septum thickness (IVST) levels were significantly higher in the VC group. Bone metabolism did not differ significantly between the 2 groups. Multivariable logistic regression analysis indicated that age, blood Ch, and LDL levels were significantly associated with VC.Advanced age, increased IVST, hypocholesterolemia, and hyper-LDL cholesterolemia were key risk factors for VC in Han patients with CKD.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29384880
OWN - NLM
STAT- In-Process
LR  - 20180131
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 5
DP  - 2018 Feb
TI  - Risk factors for heart valve calcification in chronic kidney disease.
PG  - e9804
LID - 10.1097/MD.0000000000009804 [doi]
AB  - Cardiovascular disease (CVD) is a common cause of death in patients with chronic 
      kidney disease (CKD). Aortic and mitral valve calcification (AVC and MVC,
      respectively) are critical indicators of CVD and all-cause mortality in CKD
      patients.We conducted a single center retrospective study of Chinese inpatients
      with CKD to identify risk factors associated with valve calcification (VC).Of 288
      enrolled CKD patients, 22.9% had VC, all of which exhibited AVC, while 21.2%
      exhibited MVC. The VC group were significantly older than the non-VC group (70.42
      +/- 11.83 vs 56.47 +/- 15.00, P &lt; .001), and contained more patients with history
      of coronary artery disease (12.1% vs 4.5%, P = .025) or stroke (18.2% vs 5.4%, P 
      &lt; .001). Subjective global assessment scoring indicated that more VC patients
      were mid/severely malnourished. Levels of prealbumin, cholesterol (Ch),
      triglycerides, low-density lipoprotein (LDL), apolipoprotein E, ejection
      fraction, and fraction shortening were significantly lower, and blood C reactive 
      protein, IL-6, left ventricular internal end diastole diameter measured in end
      diastole, and interventricular septum thickness (IVST) levels were significantly 
      higher in the VC group. Bone metabolism did not differ significantly between the 
      2 groups. Multivariable logistic regression analysis indicated that age, blood
      Ch, and LDL levels were significantly associated with VC.Advanced age, increased 
      IVST, hypocholesterolemia, and hyper-LDL cholesterolemia were key risk factors
      for VC in Han patients with CKD.
FAU - Rong, Shu
AU  - Rong S
AD  - Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong
      University School of Medicine, Shanghai.
FAU - Qiu, Xin
AU  - Qiu X
AD  - Department of Nephrology, Baoji City Chinese Medicine Hospital, Baoji, Shaanxi.
FAU - Jin, Xiucai
AU  - Jin X
AD  - Department of Ultrasound, Shanghai Changhai Hospital, Second Military Medical
      University, Shanghai, China.
FAU - Shang, Minghua
AU  - Shang M
AD  - Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong
      University School of Medicine, Shanghai.
FAU - Huang, Yixin
AU  - Huang Y
AD  - Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong
      University School of Medicine, Shanghai.
FAU - Tang, Zhihuan
AU  - Tang Z
AD  - Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong
      University School of Medicine, Shanghai.
FAU - Yuan, Weijie
AU  - Yuan W
AD  - Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong
      University School of Medicine, Shanghai.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2018/02/01 06:00
MHDA- 2018/02/01 06:00
CRDT- 2018/02/01 06:00
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
AID - 10.1097/MD.0000000000009804 [doi]
AID - 00005792-201802020-00042 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Feb;97(5):e9804. doi: 10.1097/MD.0000000000009804.