PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report.

Abstract Azithromycin-induced liver injury has been rarely reported in adult individuals, let alone in a pregnant woman. Here, we describe the clinical features and outcomes of azithromycin-induced liver injury in a pregnant woman.
PMID
Related Publications

Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid.

Azithromycin-induced intrahepatic cholestasis.

Prolonged intrahepatic cholestasis after exposure to loxoprofen.

Clinical practice guidelines of the Team of Experts of the Polish Gynecological Society: management of the intrahepatic cholestasis of pregnancy.

The concentrations of bile acids and erythropoietin in pregnant women with intrahepatic cholestasis and the state of the fetus and newborn.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29384912
OWN - NLM
STAT- In-Process
LR  - 20180131
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 52
DP  - 2017 Dec
TI  - Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic
      cholestasis: A case report.
PG  - e9346
LID - 10.1097/MD.0000000000009346 [doi]
AB  - RATIONALE: Azithromycin-induced liver injury has been rarely reported in adult
      individuals, let alone in a pregnant woman. Here, we describe the clinical
      features and outcomes of azithromycin-induced liver injury in a pregnant woman.
      PATIENT CONCERNS: A 30-year-old pregnant woman presented with generalized
      pruritus and elevated serum bile acid level (123.6 mumol/L) on day 4 of
      azithromycin administration. A diagnosis of intrahepatic cholestasis of pregnancy
      was made, and cesarean section was performed immediately. Interestingly, the
      alanine aminotransferase level (ALT) reached 211.2 U/L on day 9 after
      azithromycin administration. DIAGNOSIS: Therefore, drug-induced intrahepatic
      cholestasis was considered. INTERVENTIONS: (1) Azithromycin withdrawal after the 
      patient hospitalized. (2) Termination of pregnancy by cesarean section was
      performed inmmediately to protect the fetus. (3) Silymarin capsules and bifendate
      are used to protect the liver after liver enzymes elevation was discovered.
      OUTCOMES: The liver enzymes recovered within 4 weeks without any symptoms after
      treatment with silymarin capsules and bifendate, which helps reduce ALT level and
      protects the liver from further injury. LESSIONS: A pregnant woman developed
      azithromycin-induced intrahepatic cholestasis. Physicians should be aware of this
      side effect of azithromycin, which is widely prescribed.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Han, Baoshi
AU  - Han B
AD  - Centre for Reproductive Medicine.
AD  - School of Medicine, Shandong University.
AD  - National Research Center for Assisted Reproductive Technology and Reproductive
      Genetics.
AD  - The Key laboratory for Reproductive Endocrinology of Ministry of Education.
FAU - Sheng, Yan
AU  - Sheng Y
AD  - Centre for Reproductive Medicine.
AD  - National Research Center for Assisted Reproductive Technology and Reproductive
      Genetics.
AD  - The Key laboratory for Reproductive Endocrinology of Ministry of Education.
FAU - Wang, Li
AU  - Wang L
AD  - Gynaecology and Obstetrics.
FAU - Feng, Hao
AU  - Feng H
AD  - Gynaecology and Obstetrics.
FAU - Hou, Xianzeng
AU  - Hou X
AD  - Department of Neurosurgery.
FAU - Li, Yan
AU  - Li Y
AD  - School of Medicine, Shandong University.
AD  - Medical Research Center, Shandong Provincial Qianfoshan Hospital.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2018/02/01 06:00
MHDA- 2018/02/01 06:00
CRDT- 2018/02/01 06:00
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
AID - 10.1097/MD.0000000000009346 [doi]
AID - 00005792-201712290-00020 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(52):e9346. doi: 10.1097/MD.0000000000009346.