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Association between KIR gene polymorphisms and type 1 diabetes mellitus (T1DM) susceptibility: A PRISMA-compliant meta-analysis.

Abstract Type 1 diabetes mellitus (T1DM) is a T-cell mediated autoimmune disease with a complex genetic and immunological background. Evidence suggests that killer cell immunoglobulin-like receptor (KIR) genes are associated with T1DM, but the results are inconsistent. Here, we conducted a meta-analysis to comprehensively evaluate the effect of KIR genes on the risk of T1DM.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29384924
OWN - NLM
STAT- In-Process
LR  - 20180131
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 52
DP  - 2017 Dec
TI  - Association between KIR gene polymorphisms and type 1 diabetes mellitus (T1DM)
      susceptibility: A PRISMA-compliant meta-analysis.
PG  - e9439
LID - 10.1097/MD.0000000000009439 [doi]
AB  - BACKGROUND: Type 1 diabetes mellitus (T1DM) is a T-cell mediated autoimmune
      disease with a complex genetic and immunological background. Evidence suggests
      that killer cell immunoglobulin-like receptor (KIR) genes are associated with
      T1DM, but the results are inconsistent. Here, we conducted a meta-analysis to
      comprehensively evaluate the effect of KIR genes on the risk of T1DM. METHODS:
      The PubMed, Web of Science, the Chinese Biomedical Database, and Chinese National
      Knowledge Infrastructure databases were systematically searched to select studies
      on the association between KIR polymorphisms and T1DM. The quality of each study 
      was scoring in term of the Newcastle-Ottawa Scale. Pooled odds ratios (ORs) and
      95% confidence intervals (CIs) were used to assess the strength of this
      association. Subgroup analysis stratified by ethnicity was also conducted. Funnel
      plot and Egger test were conducted to assess the publication bias. RESULTS: A
      total of 13 independent case-control studies comprising 2076 T1DM cases and 1967 
      controls were included in this meta-analysis. We found a negative association
      between the KIR2DL1 polymorphism and susceptibility to T1DM in the overall
      population (OR = 0.71, 95%CI = 0.51-0.98, P = .038), but not in ethnic-specific
      analysis. Additionally, a negative association between the KIR2DS1 polymorphism
      and susceptibility to T1DM was found in the Asians (OR = 0.76, 95%CI = 0.63-0.92,
      P = .004), but not in the Caucasians. However, the associations could not
      withstand Bonferroni correction. Conversely, no association between the other
      KIRs genes (KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5, KIR2DS2, KIR2DS3, KIR2DS4,
      KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, and KIR3DS1) and T1DM susceptibility was
      found in overall and subgroup ethnicity. No publication bias was detected in all 
      comparisons. CONCLUSIONS: In summary, this meta-analysis suggested that the
      KIR2DL1 and 2DS1 polymorphism might be a potential protective factor for T1DM in 
      the specific ethnicity. Further subtle design studies with more sample size are
      still needed for a definitive conclusion.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Liu, Shu-Lan
AU  - Liu SL
AD  - Linyi People's Hospital, Linyi, Shandong, People's Republic of China.
FAU - Zheng, A-Juan
AU  - Zheng AJ
FAU - Ding, Li
AU  - Ding L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2018/02/01 06:00
MHDA- 2018/02/01 06:00
CRDT- 2018/02/01 06:00
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
AID - 10.1097/MD.0000000000009439 [doi]
AID - 00005792-201712290-00032 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(52):e9439. doi: 10.1097/MD.0000000000009439.