PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Pathogenic Mechanism and Diagnostic Testing for Drug Allergies.

Abstract  Three stages of the pathogenic mechanism of drug allergies can be considered: antigen formation, immune reaction and inflammation/disorder reaction. Drugs are thought to form 4 types of antigens: drug only, polymers, drug-carrier conjugates, and metabolite-carrier complexes. Antigens are recognized by B cell receptors and T cell receptors. Helper T cells (Th) are differentiated into four subsets, namely, Th1, Th2, Th17 and regulatory T cells (Treg). Th1 produces interleukin (IL)-2 and interferon (IFN)-γ, and activates macrophages and cytotoxic T cells (Tc). Macrophages induce type IV allergies, and Tc lead to serious type IV allergies. On the other hand, Th2 produces IL-4, IL-5, and IL-6, etc., and activates B cells. B cells produce IgE antibodies, and the IgE antibody affects mast cells and induces type I allergies. Activated eosinophil leads to the chronic state of type I allergy. Diagnostic testing for allergenic drugs is necessary for patients with drug allergies. Because in vivo diagnostic tests for allergenic drugs are associated with a risk and burden to the patient, in vitro allergy tests are recommended to identify allergenic drugs. In allergy tests performed in vitro, cytological tests are more effective than serological tests, and the leukocyte migration test (LMT) presently has the highest efficacy. An LMT-chamber is better than LMT-agarose in terms of usability and sensitivity, and it can detect about 80% of allergenic drugs.
PMID
Related Publications

Type 1 T helper and type 2 T helper cells: functions, regulation and role in protection and disease.

T cells and their role in allergies.

Human atopen-specific types 1 and 2 T helper cell clones.

Role of antigen-presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages.

Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy.

Authors

Mayor MeshTerms

Cell Migration Assays, Leukocyte

Keywords

cytokine

diagnostic testing

drug allergy

leukocyte migration test

pathogenic mechanism

Journal Title yakugaku zasshi : journal of the pharmaceutical society of japan
Publication Year Start




PMID- 29386429
OWN - NLM
STAT- MEDLINE
DCOM- 20180228
LR  - 20180228
IS  - 1347-5231 (Electronic)
IS  - 0031-6903 (Linking)
VI  - 138
IP  - 2
DP  - 2018
TI  - [Pathogenic Mechanism and Diagnostic Testing for Drug Allergies].
PG  - 151-167
LID - 10.1248/yakushi.17-00174-1 [doi]
AB  - Three stages of the pathogenic mechanism of drug allergies can be considered:
      antigen formation, immune reaction and inflammation/disorder reaction. Drugs are 
      thought to form 4 types of antigens: drug only, polymers, drug-carrier
      conjugates, and metabolite-carrier complexes. Antigens are recognized by B cell
      receptors and T cell receptors. Helper T cells (Th) are differentiated into four 
      subsets, namely, Th1, Th2, Th17 and regulatory T cells (Treg). Th1 produces
      interleukin (IL)-2 and interferon (IFN)-gamma, and activates macrophages and
      cytotoxic T cells (Tc). Macrophages induce type IV allergies, and Tc lead to
      serious type IV allergies. On the other hand, Th2 produces IL-4, IL-5, and IL-6, 
      etc., and activates B cells. B cells produce IgE antibodies, and the IgE antibody
      affects mast cells and induces type I allergies. Activated eosinophil leads to
      the chronic state of type I allergy. Diagnostic testing for allergenic drugs is
      necessary for patients with drug allergies. Because in vivo diagnostic tests for 
      allergenic drugs are associated with a risk and burden to the patient, in vitro
      allergy tests are recommended to identify allergenic drugs. In allergy tests
      performed in vitro, cytological tests are more effective than serological tests, 
      and the leukocyte migration test (LMT) presently has the highest efficacy. An
      LMT-chamber is better than LMT-agarose in terms of usability and sensitivity, and
      it can detect about 80% of allergenic drugs.
FAU - Uno, Katsuji
AU  - Uno K
AD  - Faculty of Pharmacy, Chiba Institute of Science.
AD  - Kyoeido, Co. Ltd.
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Antigens)
RN  - 0 (Cytokines)
RN  - 0 (Receptors, Antigen, B-Cell)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antigens/immunology
MH  - B-Lymphocytes/immunology
MH  - *Cell Migration Assays, Leukocyte
MH  - Cytokines/metabolism
MH  - Drug Hypersensitivity/*diagnosis/*immunology
MH  - Eosinophils/immunology
MH  - Humans
MH  - Immunoglobulin E
MH  - Macrophages/immunology
MH  - Mast Cells/immunology
MH  - Receptors, Antigen, B-Cell/immunology
MH  - Receptors, Antigen, T-Cell/immunology
MH  - Sensitivity and Specificity
MH  - T-Lymphocyte Subsets/immunology
MH  - T-Lymphocytes, Helper-Inducer/immunology
OTO - NOTNLM
OT  - cytokine
OT  - diagnostic testing
OT  - drug allergy
OT  - leukocyte migration test
OT  - pathogenic mechanism
EDAT- 2018/02/02 06:00
MHDA- 2018/03/01 06:00
CRDT- 2018/02/02 06:00
PHST- 2018/02/02 06:00 [entrez]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2018/03/01 06:00 [medline]
AID - 10.1248/yakushi.17-00174-1 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2018;138(2):151-167. doi: 10.1248/yakushi.17-00174-1.