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Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor.

Abstract The lack of novel antifungal drugs and the increasing incidence and severity of fungal infections are major concerns worldwide. Herein, we tested the activity of the Blad-containing oligomer (BCO), a new antifungal molecule already in use for agriculture, on Malassezia spp. and dermatophytes, the causal agents of human tinea versicolor and tinea pedis. Given the lack of a standard method for Malassezia susceptibility testing and the plethora of published methods, we also developed an improved method for this genus.
PMID
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Authors

Mayor MeshTerms
Keywords

Blad-containing oligomer

MIC

Malassezia

Trichophyton

antifungal

Journal Title journal of medical microbiology
Publication Year Start




PMID- 29388537
OWN - NLM
STAT- MEDLINE
DCOM- 20180206
LR  - 20180206
IS  - 1473-5644 (Electronic)
IS  - 0022-2615 (Linking)
VI  - 67
IP  - 2
DP  - 2018 Feb
TI  - Blad-containing oligomer: a novel fungicide used in crop protection as an
      alternative treatment for tinea pedis and tinea versicolor.
PG  - 198-207
LID - 10.1099/jmm.0.000675 [doi]
AB  - PURPOSE: The lack of novel antifungal drugs and the increasing incidence and
      severity of fungal infections are major concerns worldwide. Herein, we tested the
      activity of the Blad-containing oligomer (BCO), a new antifungal molecule already
      in use for agriculture, on Malassezia spp. and dermatophytes, the causal agents
      of human tinea versicolor and tinea pedis. Given the lack of a standard method
      for Malassezia susceptibility testing and the plethora of published methods, we
      also developed an improved method for this genus. METHODOLOGY: The efficacy of
      BCO was assessed in vitro and compared to that of the drugs currently utilized in
      the treatment of tinea versicolor (fluconazole and itraconazole) and tinea pedis 
      (itraconazole and terbinafine). For dermatophytes, the standard microdilution
      broth-based method was used, with small adjustments, and several broth
      formulations and inocula sizes were tested to develop an improved susceptibility 
      method for Malassezia spp. RESULTS: We successfully developed a microdilution
      broth-based method with considerable advantages over other available methods, and
      used it for all in vitro susceptibility tests of Malassezia spp. isolates. We
      report that, on a molar basis, BCO was more effective than fluconazole or
      itraconazole on most strains of Malassezia spp. isolated from clinical samples
      (n=29). By contrast, BCO was less effective than itraconazole or terbinafine on
      the common dermatophytes Trichophyton rubrum and Trichophyton interdigitale.
      CONCLUSION: These data place BCO as a promising drug for the treatment of
      Malassezia-associated skin diseases. Further in vivo studies are now required to 
      ascertain its applicability in the clinical setting.
FAU - Carreira, Alexandra
AU  - Carreira A
AD  - 1CEV, SA, Parque Industrial de Cantanhede/Biocant-Park, lote 120, 3060-197
      Cantanhede, Portugal.
FAU - Ferreira, Joao Boavida
AU  - Ferreira JB
AD  - 2Hospital de Santa Maria, Faculdade de Medicina de Lisboa, Clinica Dermatologica 
      Universitaria, Avenida Prof. Egas Moniz, 1699 Lisboa Codex, Portugal.
FAU - Pereira, Iliana
AU  - Pereira I
AD  - 1CEV, SA, Parque Industrial de Cantanhede/Biocant-Park, lote 120, 3060-197
      Cantanhede, Portugal.
FAU - Ferreira, Joao
AU  - Ferreira J
AD  - 2Hospital de Santa Maria, Faculdade de Medicina de Lisboa, Clinica Dermatologica 
      Universitaria, Avenida Prof. Egas Moniz, 1699 Lisboa Codex, Portugal.
AD  - 3Unidade de Investigacao em Dermatologia, Instituto de Medicina Molecular,
      Avenida Prof. Egas Moniz, 1699 Lisboa Codex, Portugal.
FAU - Filipe, Paulo
AU  - Filipe P
AD  - 2Hospital de Santa Maria, Faculdade de Medicina de Lisboa, Clinica Dermatologica 
      Universitaria, Avenida Prof. Egas Moniz, 1699 Lisboa Codex, Portugal.
AD  - 3Unidade de Investigacao em Dermatologia, Instituto de Medicina Molecular,
      Avenida Prof. Egas Moniz, 1699 Lisboa Codex, Portugal.
FAU - Ferreira, Ricardo Boavida
AU  - Ferreira RB
AD  - 4LEAF - Linking Landscape, Environment, Agriculture and Food, Instituto Superior 
      de Agronomia, Universidade de Lisboa, 1349-017 Lisboa, Portugal.
FAU - Monteiro, Sara
AU  - Monteiro S
AD  - 1CEV, SA, Parque Industrial de Cantanhede/Biocant-Park, lote 120, 3060-197
      Cantanhede, Portugal.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Med Microbiol
JT  - Journal of medical microbiology
JID - 0224131
RN  - 0 (Antifungal Agents)
RN  - 0 (Fungicides, Industrial)
RN  - 304NUG5GF4 (Itraconazole)
RN  - 8VZV102JFY (Fluconazole)
SB  - IM
MH  - Antifungal Agents/*pharmacology/therapeutic use
MH  - Arthrodermataceae/*drug effects
MH  - Crop Protection
MH  - Drug Discovery
MH  - Fluconazole/pharmacology
MH  - Fungicides, Industrial/*pharmacology/therapeutic use
MH  - Humans
MH  - Itraconazole/pharmacology
MH  - Malassezia/*drug effects
MH  - Microbial Sensitivity Tests
MH  - Tinea Pedis/*drug therapy/microbiology
MH  - Tinea Versicolor/*drug therapy/microbiology
MH  - Trichophyton/drug effects
OTO - NOTNLM
OT  - Blad-containing oligomer
OT  - MIC
OT  - Malassezia
OT  - Trichophyton
OT  - antifungal
EDAT- 2018/02/02 06:00
MHDA- 2018/02/07 06:00
CRDT- 2018/02/02 06:00
PHST- 2018/02/02 06:00 [entrez]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2018/02/07 06:00 [medline]
AID - 10.1099/jmm.0.000675 [doi]
PST - ppublish
SO  - J Med Microbiol. 2018 Feb;67(2):198-207. doi: 10.1099/jmm.0.000675.