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The improvement of dry eye after cataract surgery by intraoperative using ophthalmic viscosurgical devices on the surface of cornea: The results of a consort-compliant randomized controlled trial.

Abstract This study aimed to investigate the protective effect of intraoperative used hydroxypropyl methylcellulose (HPMC 2%) on the ocular surface after cataract surgery.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390284
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - The improvement of dry eye after cataract surgery by intraoperative using
      ophthalmic viscosurgical devices on the surface of cornea: The results of a
      consort-compliant randomized controlled trial.
PG  - e8940
LID - 10.1097/MD.0000000000008940 [doi]
AB  - BACKGROUD: This study aimed to investigate the protective effect of
      intraoperative used hydroxypropyl methylcellulose (HPMC 2%) on the ocular surface
      after cataract surgery. METHODS: A total of 149 eyes (149 patients) diagnosed
      with age-related cataract, age 69.19 +/- 9.74 years, were enrolled in this
      prospective, parallel-design, continuous, randomised controlled study. Patients
      were randomly assigned to receive HPMC 2% (study group) or balanced salt solution
      (control group) during the surgery to moisturize the cornea surface. The Ocular
      Surface Disease Index, Schirmer test without topical anesthetics, tear break-up
      time, and corneal fluorescein staining were assessed preoperatively, 1 day, 1
      week, and 1 month after the surgery, respectively. RESULTS: The Schirmer test
      value of male patients in the study group at 1 week postoperation was higher than
      that of male patients in the control group (P = .019). For patients diagnosed
      with dry eye before the surgery, Schirmer test value in the male patients in the 
      study group at 1 month after surgery was higher than that in the male patients in
      the control group (P = .037). Furthermore, for the cluster of preoperative dry
      eye patients whose surgical time was longer than median, corneal fluorescein
      staining of the patients in the study group was superior to that of the patients 
      in the control group (P = .032). CONCLUSION: Intraoperative use of HPMC 2% on the
      cornea surface could improve clinical outcomes of tear film and ocular surface
      health to some degree, especially in the patients diagnosed with dry eye before
      the surgery, male patients, and patients whose surgical time was relatively
      longer.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - He, Yuan
AU  - He Y
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University,
      Beijing Ophthalmology & Visual Sciences Key Laboratory.
FAU - Li, Jia
AU  - Li J
AD  - Beijing Children's Hospital, Capital Medical University, Beijing.
FAU - Zhu, Jingfen
AU  - Zhu J
AD  - School Of Public Health, Shanghai Jiao Tong University, Shanghai, China.
FAU - Jie, Ying
AU  - Jie Y
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University,
      Beijing Ophthalmology & Visual Sciences Key Laboratory.
FAU - Wang, Ningli
AU  - Wang N
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University,
      Beijing Ophthalmology & Visual Sciences Key Laboratory.
FAU - Wang, Jun
AU  - Wang J
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University,
      Beijing Ophthalmology & Visual Sciences Key Laboratory.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Ophthalmic Solutions)
RN  - 3NXW29V3WO (Hypromellose Derivatives)
SB  - AIM
SB  - IM
MH  - Aged
MH  - Cataract Extraction/*methods
MH  - Cornea
MH  - Dry Eye Syndromes/etiology/*prevention & control
MH  - Female
MH  - Humans
MH  - Hypromellose Derivatives/*therapeutic use
MH  - Intraoperative Care
MH  - Male
MH  - Ophthalmic Solutions/*therapeutic use
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000008940 [doi]
AID - 00005792-201712150-00034 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e8940. doi: 10.1097/MD.0000000000008940.