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The influence of artificial nucleus pulposus replacement on stress distribution in the cartilaginous endplate in a 3-dimensional finite element model of the lumbar intervertebral disc.

Abstract This study aimed to investigate the effects involved with the artificial nucleus pulposus (NP) replacement on stress distribution of the cartilaginous endplate (CEP) in a 3-dimensional lumbar intervertebral disc (IVD) model using a finite element (FE) analysis.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390319
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20180213
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - The influence of artificial nucleus pulposus replacement on stress distribution
      in the cartilaginous endplate in a 3-dimensional finite element model of the
      lumbar intervertebral disc.
PG  - e9149
LID - 10.1097/MD.0000000000009149 [doi]
AB  - OBJECTIVE: This study aimed to investigate the effects involved with the
      artificial nucleus pulposus (NP) replacement on stress distribution of the
      cartilaginous endplate (CEP) in a 3-dimensional lumbar intervertebral disc (IVD) 
      model using a finite element (FE) analysis. METHODS: A healthy male volunteer was
      recruited for the purposes of the study and a spiral computed tomography scan was
      subsequently conducted to obtain the data information in relation to the L4/5
      motion segment. An FE model of the L4/5 motion segment constructed, on the basis 
      of which degenerative IVD, IVD with NP removal, and IVD with NP replacement were 
      in turn built. The stress distribution of the CEP and bulging of IVD were
      estimated using various motion states, including axial loading, forward flexion, 
      backward extension, left axial rotation, and right axial rotation. RESULTS: Under
      different motion states, the vertebral stress was higher in the degenerative IVD,
      the IVD with NP removal, and the IVD with NP replacement, in comparison to that
      of the normal IVD. Furthermore, a higher vertebral stress was detected in the
      degenerative IVD than the IVD with NP removal and the IVD with NP replacement. An
      even distribution of vertebral stress was observed in the IVD model with an
      artificial NP replacement, while the vertebral stress and bulging displacement
      were lower than after NP removal. Our findings provided confirmation that stress 
      of the CEP was consistent with the vertebral stress. CONCLUSION: This study
      provided evidence suggesting that NP replacement, vertebral stress, and bulging
      displacement are lower than that of degenerative IVD and IVD with NP removal
      under different motion states.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Wang, Yu
AU  - Wang Y
AD  - Department of Orthopedics, Peking University First Hospital, Beijing, China.
FAU - Yi, Xiao-Dong
AU  - Yi XD
FAU - Li, Chun-De
AU  - Li CD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Biomechanical Phenomena
MH  - Computer Simulation
MH  - Diskectomy
MH  - Finite Element Analysis
MH  - Healthy Volunteers
MH  - Humans
MH  - Intervertebral Disc Degeneration/*surgery
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Models, Anatomic
MH  - Nucleus Pulposus/*surgery
MH  - Stress, Mechanical
MH  - Tomography, Spiral Computed
MH  - Young Adult
EDAT- 2018/02/03 06:00
MHDA- 2018/02/14 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
AID - 10.1097/MD.0000000000009149 [doi]
AID - 00005792-201712150-00069 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9149. doi: 10.1097/MD.0000000000009149.