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Case report: Ribavirin and vitamin A in a severe case of measles.

Abstract Despite a vaccine being widely available, measles continues to occur frequently, with sometimes lethal consequences.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390321
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20180213
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - Case report: Ribavirin and vitamin A in a severe case of measles.
PG  - e9154
LID - 10.1097/MD.0000000000009154 [doi]
AB  - RATIONALE: Despite a vaccine being widely available, measles continues to occur
      frequently, with sometimes lethal consequences. PATIENTS CONCERNS: The mortality 
      rate reaches 35% and measles represents 44% of the 1.4 million deaths which are
      due to preventable diseases. Severe forms of measles are reported, mainly in
      young, unvaccinated adults, and in specific populations. The risk factors for
      severe measles include no or incomplete vaccination and vitamin A deficiency.
      Apart from secondary measles-related infections, severe measles is mainly
      represented by neurological, respiratory, and digestive symptoms. DIAGNOSES:
      Strengthening the hypothesis that there is a link between vitamin A deficiency
      and severe measles in this paper we report the case of a 25-year-old unvaccinated
      man hospitalized for severe and complicated measles. OUTCOMES: The evolution was 
      good after administration of intramuscular vitamin A as well as intravenous
      ribavirin. LESSONS: Measles remains a fatal and serious disease. The early use of
      ribavirin and vitamin A shows significant improvements regarding morbimortality
      and should be systematic in severe cases.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Bichon, Amandine
AU  - Bichon A
AD  - Aix Marseille Univ, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU
      Mediterranee-Infection, 19-21 Boulevard Jean Moulin, Marseille Cedex 5.
FAU - Aubry, Camille
AU  - Aubry C
AD  - Aix Marseille Univ, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU
      Mediterranee-Infection, 19-21 Boulevard Jean Moulin, Marseille Cedex 5.
FAU - Benarous, Lucas
AU  - Benarous L
AD  - Assistance Publique Hopitaux de Marseille, CHU Timone, Service de reanimation
      medicale, Marseille, France.
FAU - Drouet, Hortense
AU  - Drouet H
AD  - Aix Marseille Univ, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU
      Mediterranee-Infection, 19-21 Boulevard Jean Moulin, Marseille Cedex 5.
FAU - Zandotti, Christine
AU  - Zandotti C
AD  - Aix Marseille Univ, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU
      Mediterranee-Infection, 19-21 Boulevard Jean Moulin, Marseille Cedex 5.
FAU - Parola, Philippe
AU  - Parola P
AD  - Aix Marseille Univ, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU
      Mediterranee-Infection, 19-21 Boulevard Jean Moulin, Marseille Cedex 5.
FAU - Lagier, Jean-Christophe
AU  - Lagier JC
AD  - Aix Marseille Univ, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU
      Mediterranee-Infection, 19-21 Boulevard Jean Moulin, Marseille Cedex 5.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antiviral Agents)
RN  - 11103-57-4 (Vitamin A)
RN  - 49717AWG6K (Ribavirin)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Antiviral Agents/*therapeutic use
MH  - Humans
MH  - Male
MH  - Measles/complications/*prevention & control
MH  - Ribavirin/*therapeutic use
MH  - Vitamin A/*therapeutic use
EDAT- 2018/02/03 06:00
MHDA- 2018/02/14 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
AID - 10.1097/MD.0000000000009154 [doi]
AID - 00005792-201712150-00071 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9154. doi: 10.1097/MD.0000000000009154.