PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Hemophagocytic lymphohistiocytosis complicated by multiorgan failure: A case report.

Abstract We present a case of hemophagocytic lymphohistiocytosis (HLH) with severe pulmonary complication and acute respiratory distress syndrome (ARDS) hospitalized in our intensive care unit (ICU) in 2014; distinctive trait of this case has been the challenging diagnosis, with a bone marrow biopsy always negative, the severe pulmonary complication with ARDS and severe pulmonary hypertension, and the ferritin temporal kinetics that precisely followed the clinical course of disease.
PMID
Related Publications

Hemophagocytic lymphohistiocytosis in a patient with Goodpasture's syndrome: a rare clinical association.

Rituximab, etoposide, methylprednisolone, high-dose cytarabine, and cisplatin in the treatment of secondary hemophagocytic lymphohistiocytosis with classical Hodgkin lymphoma: a case report and review of the literature.

An unusual cause of multiple organ dysfunction syndrome in the pediatric intensive care unit: hemophagocytic lymphohistiocytosis.

Pregnancy-related hemophagocytic lymphohistiocytosis associated with cytomegalovirus infection: A diagnostic and therapeutic challenge.

Secondary hemophagocytic lymphohistiocytosis in the setting of metastatic renal cell carcinoma: a case report.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390336
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - Hemophagocytic lymphohistiocytosis complicated by multiorgan failure: A case
      report.
PG  - e9198
LID - 10.1097/MD.0000000000009198 [doi]
AB  - RATIONALE: We present a case of hemophagocytic lymphohistiocytosis (HLH) with
      severe pulmonary complication and acute respiratory distress syndrome (ARDS)
      hospitalized in our intensive care unit (ICU) in 2014; distinctive trait of this 
      case has been the challenging diagnosis, with a bone marrow biopsy always
      negative, the severe pulmonary complication with ARDS and severe pulmonary
      hypertension, and the ferritin temporal kinetics that precisely followed the
      clinical course of disease. PATIENT CONCERNS: A 32-year-old woman from the
      Philippines first diagnosed with upper airway infection, was subsequently
      hospitalized in infectious disease department and treated for community acquired 
      pneumonia. DIAGNOSES: After clinical picture worsened with a profound respiratory
      insufficiency, the patient was intubated and transferred to our ICU. During this 
      hospitalization, the clinical picture of fever, cutaneous rashes, lymphadenitis, 
      hepatitis, leukopenia, anemia, hyperferritinemia, hypertriglyceridemia, high
      level of auto-antibodies, and low NK activity suggested an hemophagocytic
      lymphohistiocytosis syndrome, even if bone marrow biopsy was negative for
      hemophagocytosis. INTERVENTIONS: Immunosuppressive therapy with dexamethasone and
      etoposide was started, and the patient was discharged from ICU 4 months after
      admission. LESSONS: HLH is a rare disorder of the mononuclear phagocytic system, 
      characterized by systemic proliferation of non- neoplastic histiocytes. The
      diagnosis is often challenging and not all of the diagnostic criteria may be
      present at the same time; this case shows how complex the diagnosis could be, how
      hematic ferritin levels could help in following the course of the disease, and
      the possibility of severe pulmonary complication either due to the disease itself
      and to possible sovra infections.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Lovisari, Federica
AU  - Lovisari F
AD  - Department of Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano
      Niguarda. P.zza Ospedale Maggiore, Milan.
FAU - Terzi, Valeria
AU  - Terzi V
AD  - Department of Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano
      Niguarda. P.zza Ospedale Maggiore, Milan.
FAU - Lippi, Monica G
AU  - Lippi MG
AD  - Department of Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano
      Niguarda. P.zza Ospedale Maggiore, Milan.
FAU - Brioschi, Paolo R
AU  - Brioschi PR
AD  - Department of Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano
      Niguarda. P.zza Ospedale Maggiore, Milan.
FAU - Fumagalli, Roberto
AU  - Fumagalli R
AD  - Department of Anesthesia and Critical Care, ASST Grande Ospedale Metropolitano
      Niguarda. P.zza Ospedale Maggiore, Milan.
AD  - University of Milan-Bicocca School of Medicine and Surgery, Via Cadore, Monza,
      MB, Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Glucocorticoids)
RN  - 0 (Topoisomerase II Inhibitors)
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Dexamethasone/therapeutic use
MH  - Diagnosis, Differential
MH  - Drug Therapy, Combination
MH  - Etoposide/therapeutic use
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Lymphohistiocytosis, Hemophagocytic/*complications/*diagnosis/drug therapy
MH  - Multiple Organ Failure/*diagnosis/drug therapy/*etiology
MH  - Topoisomerase II Inhibitors/therapeutic use
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009198 [doi]
AID - 00005792-201712150-00086 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9198. doi: 10.1097/MD.0000000000009198.