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Health-related quality of life and psychological status of women with primary Sjögren's syndrome: A cross-sectional study of 304 Chinese patients.

Abstract Patients with primary Sjögren syndrome (pSS) always suffer from dryness, pain, and fatigue caused by the involvement of multiple different systems or organs. The uncomfortable disease symptoms, the consequent disability, and the side effects of therapeutic drugs decrease the quality of life and lead to emotional problems. We investigated the health-related quality of life and psychological status of a large cohort of women patients with pSS and associated factors.A total of 304 women with pSS referred to Peking Union Medical College Hospital during 2011 and 2014 were included. The internationally recognized Short Form (36) Health Survey (SF-36) was used to assess patients' quality of life; a higher score indicated a better quality of life. Patients' psychological status was assessed by the Hospital Anxiety and Depression Scale (HADS), and higher scores predicted more anxiety or depression.Patients with pSS had remarkably lower SF-36 scores. The Hospital Anxiety Scale (HAS) and Hospital Depression Scale (HDS) scores of the pSS patients (7 [4,10] and 6 [3,10], respectively) were significantly higher than that of patients with other internal diseases (3.37 ± 2.81 and 3.83 ± 3.14; both P < .001). Negative predictors of quality of life were: pain (physical condition, β = -0.225; P < .001); fatigue (physical condition, β = -0.298; P < .001; and mental condition, β = -0.319; P < .001). Risk factors for anxiety were: young age (β = -0.059; P = .035); pain (β = 0.025; P = .028); or fatigue (β = 0.029; P = .004). Risk factors for depression were: xeroderma (β = 0.030; P = .003); pain (β = 0.022; P = .047); or fatigue (β = 0.033; P = .001).Patients with pSS have a low quality of life with anxiety and depression. Pain and fatigue are primary factors for lower quality of life, which cause more anxiety and depression.
PMID
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Authors

Mayor MeshTerms

Quality of Life

Keywords
Journal Title medicine
Publication Year Start




PMID- 29390343
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - Health-related quality of life and psychological status of women with primary
      Sjogren's syndrome: A cross-sectional study of 304 Chinese patients.
PG  - e9208
LID - 10.1097/MD.0000000000009208 [doi]
AB  - Patients with primary Sjogren syndrome (pSS) always suffer from dryness, pain,
      and fatigue caused by the involvement of multiple different systems or organs.
      The uncomfortable disease symptoms, the consequent disability, and the side
      effects of therapeutic drugs decrease the quality of life and lead to emotional
      problems. We investigated the health-related quality of life and psychological
      status of a large cohort of women patients with pSS and associated factors.A
      total of 304 women with pSS referred to Peking Union Medical College Hospital
      during 2011 and 2014 were included. The internationally recognized Short Form
      (36) Health Survey (SF-36) was used to assess patients' quality of life; a higher
      score indicated a better quality of life. Patients' psychological status was
      assessed by the Hospital Anxiety and Depression Scale (HADS), and higher scores
      predicted more anxiety or depression.Patients with pSS had remarkably lower SF-36
      scores. The Hospital Anxiety Scale (HAS) and Hospital Depression Scale (HDS)
      scores of the pSS patients (7 [4,10] and 6 [3,10], respectively) were
      significantly higher than that of patients with other internal diseases (3.37 +/-
      2.81 and 3.83 +/- 3.14; both P &lt; .001). Negative predictors of quality of life
      were: pain (physical condition, beta = -0.225; P &lt; .001); fatigue (physical
      condition, beta = -0.298; P &lt; .001; and mental condition, beta = -0.319; P &lt;
      .001). Risk factors for anxiety were: young age (beta = -0.059; P = .035); pain
      (beta = 0.025; P = .028); or fatigue (beta = 0.029; P = .004). Risk factors for
      depression were: xeroderma (beta = 0.030; P = .003); pain (beta = 0.022; P =
      .047); or fatigue (beta = 0.033; P = .001).Patients with pSS have a low quality
      of life with anxiety and depression. Pain and fatigue are primary factors for
      lower quality of life, which cause more anxiety and depression.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Liu, Zhaoxiang
AU  - Liu Z
AD  - Department of Traditional Chinese Medicine, Translational Medicine Center, Peking
      Union Medical College Hospital, Chinese Academy of Medical Science.
AD  - Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua
      University, Beijing, China.
FAU - Dong, Zhenhua
AU  - Dong Z
AD  - Department of Traditional Chinese Medicine, Translational Medicine Center, Peking
      Union Medical College Hospital, Chinese Academy of Medical Science.
FAU - Liang, Xiaochun
AU  - Liang X
AD  - Department of Traditional Chinese Medicine, Translational Medicine Center, Peking
      Union Medical College Hospital, Chinese Academy of Medical Science.
FAU - Liu, Jinhe
AU  - Liu J
AD  - Department of Traditional Chinese Medicine, Translational Medicine Center, Peking
      Union Medical College Hospital, Chinese Academy of Medical Science.
FAU - Xuan, Lei
AU  - Xuan L
AD  - Department of Traditional Chinese Medicine, Translational Medicine Center, Peking
      Union Medical College Hospital, Chinese Academy of Medical Science.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Traditional Chinese Medicine, Translational Medicine Center, Peking
      Union Medical College Hospital, Chinese Academy of Medical Science.
FAU - Zhang, Gaili
AU  - Zhang G
AD  - Department of Traditional Chinese Medicine, Translational Medicine Center, Peking
      Union Medical College Hospital, Chinese Academy of Medical Science.
FAU - Hao, Weixin
AU  - Hao W
AD  - Department of Traditional Chinese Medicine, Translational Medicine Center, Peking
      Union Medical College Hospital, Chinese Academy of Medical Science.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - Anxiety/psychology
MH  - China
MH  - Cross-Sectional Studies
MH  - Depression/psychology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - *Quality of Life
MH  - Sjogren's Syndrome/*psychology
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009208 [doi]
AID - 00005792-201712150-00093 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9208. doi: 10.1097/MD.0000000000009208.