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A case of immunoglobulin G4-related lung disease with bilateral diffuse infiltration: A case report.

Abstract Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a rare and chronic progressive autoimmune disease. It is a novel clinical entity characterized by elevated serum IgG4 concentration and tissue infiltration by IgG4 plasma cells. IgG4-related lung disease (IgG4-RLD) has been described as interstitial pneumonia and inflammatory pseudotumor, with various abnormal radiographic patterns. We report a case of IgG4-related lung disease with bilateral diffuse infiltration.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390345
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - A case of immunoglobulin G4-related lung disease with bilateral diffuse
      infiltration: A case report.
PG  - e9211
LID - 10.1097/MD.0000000000009211 [doi]
AB  - RATIONALE: Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a rare and chronic
      progressive autoimmune disease. It is a novel clinical entity characterized by
      elevated serum IgG4 concentration and tissue infiltration by IgG4 plasma cells.
      IgG4-related lung disease (IgG4-RLD) has been described as interstitial pneumonia
      and inflammatory pseudotumor, with various abnormal radiographic patterns. We
      report a case of IgG4-related lung disease with bilateral diffuse infiltration.
      PATIENT CONCERNS: A 65-year-old woman was admitted to our hospital because of
      cough, sputum, and fever. Chest computed tomography (CT) revealed multifocal
      areas of consolidations, nodules, and ground glass opacities in both lungs. She
      still had fever after anti-infective therapy. DIAGNOSES: Bronchial bronchoscopy
      and percutaneous lung biopsy were performed, resulted in a pathological diagnosis
      of IgG4-RLD. INTERVENTIONS: The patient was started on oral prednisolone 30
      mg/day for 28 days, and then was gradually tapered. OUTCOMES: After one week
      treatment, the temperature was stable, CT showed significant improvement in the
      areas of consolidations and nodules. LESSONS: It is a typical case of IgG4-RLD.
      This case indicated that suggestive evidence, radiological appearances, serum
      tests, pathological characteristics, and classic therapy IgG4-RLD. It is a rare
      disease that needs our more attention in future.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Liu, Ailing
AU  - Liu A
FAU - Zhang, Qianwen
AU  - Zhang Q
FAU - Liu, Bo
AU  - Liu B
FAU - Xu, Ning
AU  - Xu N
FAU - Li, Aijun
AU  - Li A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Glucocorticoids)
RN  - 0 (Immunoglobulin G)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - AIM
SB  - IM
MH  - Aged
MH  - Autoimmune Diseases/*diagnosis/drug therapy
MH  - Biopsy
MH  - Bronchoscopy
MH  - Diagnosis, Differential
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Immunoglobulin G/*immunology
MH  - Lung Diseases/*diagnosis/drug therapy
MH  - Prednisolone/therapeutic use
MH  - Rare Diseases
MH  - Tomography, X-Ray Computed
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009211 [doi]
AID - 00005792-201712150-00095 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9211. doi: 10.1097/MD.0000000000009211.