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PMID- 29390348
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - Utility of KRAS mutational analysis in the preoperative diagnosis of synchronous 
      pancreatic cancer and intrahepatic cholangiocarcinoma: A case report.
PG  - e9217
LID - 10.1097/MD.0000000000009217 [doi]
AB  - RATIONALE: It is often challenging to discriminate between intrahepatic
      cholangiocarcinoma (ICC) and metastatic liver tumors, especially when the hepatic
      tumor is small and of a mass-forming type. PATIENT CONCERNS: We report a
      69-year-old woman presented at our hospital with a small solid tumor in the head 
      of the pancreas that was previously discovered during a medical checkup.
      DIAGNOSES: The patient was diagnosed with synchronous pancreatic cancer and ICC. 
      INTERVENTIONS: The patient underwent clinical, histological, immunohistological, 
      and KRAS mutational analysis. OUTCOMES: Computed tomography revealed poorly
      enhanced small nodules in both the pancreatic head and liver. Biopsies of both
      nodules revealed adenocarcinoma; however, it was unclear whether the hepatic
      lesion was a metastasis of the pancreatic tumor or primary ICC. KRAS mutational
      analysis from FFPE biopsy samples revealed a discordance of mutation status
      between the tumors. Therefore, the patient was diagnosed with synchronous
      pancreatic cancer and ICC, whereupon she underwent hepatopancreatoduodenectomy.
      LESSONS: KRAS mutational analysis of FFPE biopsy samples can be utilized for
      differentiating between ICC and metastatic liver tumor.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Eso, Yuji
AU  - Eso Y
AD  - Department of Gastroenterology and Hepatology.
FAU - Uza, Norimitsu
AU  - Uza N
AD  - Department of Gastroenterology and Hepatology.
FAU - Yamagishi, Hiroko
AU  - Yamagishi H
AD  - Integrated Clinical Education Center.
FAU - Imada, Kazuaki
AU  - Imada K
AD  - Department of Cardiovascular Medicine, Kyoto University Hospital.
FAU - Kimura, Yuto
AU  - Kimura Y
AD  - Department of Gastroenterology and Hepatology.
FAU - Masui, Toshihiko
AU  - Masui T
AD  - Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto,
      Japan.
FAU - Kodama, Yuzo
AU  - Kodama Y
AD  - Department of Gastroenterology and Hepatology.
FAU - Seno, Hiroshi
AU  - Seno H
AD  - Department of Gastroenterology and Hepatology.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (KRAS protein, human)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
SB  - AIM
SB  - IM
MH  - Aged
MH  - Bile Duct Neoplasms/*diagnosis/*genetics/surgery
MH  - Cholangiocarcinoma/*diagnosis/*genetics/surgery
MH  - DNA Mutational Analysis
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Neoplasms, Multiple Primary/*diagnosis/*genetics/surgery
MH  - Pancreatic Neoplasms/*diagnosis/*genetics/surgery
MH  - Proto-Oncogene Proteins p21(ras)/*genetics
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009217 [doi]
AID - 00005792-201712150-00098 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9217. doi: 10.1097/MD.0000000000009217.