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Association between rs11200014, rs2981579, and rs1219648 polymorphism and breast cancer susceptibility: A meta-analysis.

Abstract Research on the polymorphism of breast cancer (BC) helps to search the BC susceptibility gene for mass screening, early diagnosis, and gene therapy, which has become a hotspot in BC research field. Previous studies have suggested associations between rs11200014, rs2981579, and rs1219648 polymorphisms and cancer risk. The aim of this study was to evaluate the relationship between rs11200014, rs2981579, and rs1219648 polymorphism and BC risk.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords
Journal Title medicine
Publication Year Start




PMID- 29390357
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - Association between rs11200014, rs2981579, and rs1219648 polymorphism and breast 
      cancer susceptibility: A meta-analysis.
PG  - e9246
LID - 10.1097/MD.0000000000009246 [doi]
AB  - BACKGROUND: Research on the polymorphism of breast cancer (BC) helps to search
      the BC susceptibility gene for mass screening, early diagnosis, and gene therapy,
      which has become a hotspot in BC research field. Previous studies have suggested 
      associations between rs11200014, rs2981579, and rs1219648 polymorphisms and
      cancer risk. The aim of this study was to evaluate the relationship between
      rs11200014, rs2981579, and rs1219648 polymorphism and BC risk. METHODS: PubMed,
      Web of science, and the Cochrane Library databases were searched before October
      11, 2015, to identify relevant studies. Odds ratios (ORs) and 95% confidence
      intervals (CIs) were used to estimate the strength of associations. Sensitivity
      and subgroup analyses were conducted. All included cases should have been
      diagnosed by a pathological examination. RESULTS: Twenty-six studies published
      from 2007 to 2015 were included in this meta-analysis. The pooled results showed 
      that there was a significant association between all the 3 variants and BC risk
      in any genetic model. When stratified by Source of controls, the results showed
      the same association between rs2981579 polymorphism and BC susceptibility in
      hospital-based (HB) group, although there was not any genetic model attained
      statistical correlation in population-based (PB) group. Subgroup analysis was
      performed on rs1219648 by ethnicity and Source of controls, and the effects
      remained in Asians, Caucasians, HB, and PB groups. CONCLUSION: This meta-analysis
      of case-control studies provides strong evidence that fibroblast growth factor 2 
      (FGFR2; rs11200014, rs2981579, and rs1219648) polymorphisms are significantly
      associated with the BC risk. For rs2981579, the association remained in hospital 
      populations, while not in general populations. For rs1219648, the association
      remained in Asians, Caucasians, hospital populations, and general populations.
      However, further large-scale multicenter epidemiological studies are warranted to
      confirm this finding and the molecular mechanism for the associations need to be 
      elucidated in future studies.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Zhang, Yafei
AU  - Zhang Y
AD  - Department of General Surgery, the Second Affiliated Hospital of Xi'an Jiaotong
      University, Xi'an, Shaanxi, China.
FAU - Lu, Hongwei
AU  - Lu H
FAU - Ji, Hong
AU  - Ji H
FAU - Lu, Le
AU  - Lu L
FAU - Liu, Pengdi
AU  - Liu P
FAU - Hong, Ruofeng
AU  - Hong R
FAU - Li, Yiming
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Breast Neoplasms/*genetics
MH  - Disease Susceptibility
MH  - Female
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009246 [doi]
AID - 00005792-201712150-00107 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9246. doi: 10.1097/MD.0000000000009246.