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Esophageal neuroendocrine tumor with initial presentation as painless forehead and neck masses: A case report.

Abstract Esophageal neuroendocrine tumors (NETs) are a rare type of esophageal tumor which are usually positive for chromogranin A, synaptophysin, and CD56 in tumor immunohistochemical staining. The most common symptoms of esophageal NETs are gastrointestinal symptoms such as dysphagia and/or abdominal discomfort. While esophageal NETs have the potential for distant metastasis, there have only been a few reports of brain metastasis originating from esophageal NET.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390385
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - Esophageal neuroendocrine tumor with initial presentation as painless forehead
      and neck masses: A case report.
PG  - e9282
LID - 10.1097/MD.0000000000009282 [doi]
AB  - RATIONALE: Esophageal neuroendocrine tumors (NETs) are a rare type of esophageal 
      tumor which are usually positive for chromogranin A, synaptophysin, and CD56 in
      tumor immunohistochemical staining. The most common symptoms of esophageal NETs
      are gastrointestinal symptoms such as dysphagia and/or abdominal discomfort.
      While esophageal NETs have the potential for distant metastasis, there have only 
      been a few reports of brain metastasis originating from esophageal NET. PATIENT
      CONCERNS: We report the case of a 60-year-old Taiwanese female who initially
      presented with a 1 month history of painless forehead and bilateral neck masses. 
      She did not complain of any other symptoms, which complicated the diagnosis.
      DIAGNOSES: Chest and abdominal computed tomography were arranged for a thorough
      evaluation, and a paraesophageal lesion as well as multiple metastases in the
      liver, bilateral adrenal glands, and bone were found. Panendoscopy and pathology 
      confirmed the diagnosis of an esophageal NET. INTERVENTIONS: Best supportive
      care. OUTCOMES: The clinical course of this case deteriorated drastically, and
      she died of tumor progression 10 days after the diagnosis had been made. LESSONS:
      To the best of our knowledge, this is the first article in the literature to
      report a case of esophageal NET whose initial presentation was painless forehead 
      and bilateral neck masses. Clinicians should be aware of the early signs and
      symptoms of esophageal NET to allow for a prompt diagnosis.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Chin, Yen-Po
AU  - Chin YP
AD  - Faculty of Medicine, National Yang-Ming University, Taipei.
FAU - Lai, Wei-Fu
AU  - Lai WF
AD  - Faculty of Medicine, National Yang-Ming University, Taipei.
FAU - Chiang, Meng-Ting
AU  - Chiang MT
AD  - Faculty of Medicine, National Yang-Ming University, Taipei.
FAU - Chang, Shih-Chieh
AU  - Chang SC
AD  - Faculty of Medicine, National Yang-Ming University, Taipei.
AD  - Division of Chest Medicine, Department of Internal Medicine, National Yang-Ming
      University Hospital, Yilan, Taiwan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Biopsy
MH  - Diagnosis, Differential
MH  - Diagnostic Imaging
MH  - Esophageal Neoplasms/*diagnosis
MH  - Fatal Outcome
MH  - Female
MH  - Forehead
MH  - Humans
MH  - Middle Aged
MH  - Neck
MH  - Neuroendocrine Tumors/*diagnosis
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009282 [doi]
AID - 00005792-201712150-00135 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9282. doi: 10.1097/MD.0000000000009282.