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Circulating microRNA expression and their target genes in deep vein thrombosis: A systematic review and bioinformatics analysis.

Abstract Clinically, D-dimer is the only established biomarker for the diagnosis of deep vein thrombosis (DVT). However, low specificity discounts its diagnostic value. Several publications have illustrated the differentially expressed circulating microRNAs (miRNAs) and their potential diagnostic values for DVT patients. Therefore, we systematically evaluated present researches and further performed bioinformatics analysis, to provide new insights into the diagnosis and underlying mechanisms of miRNAs in DVT.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390402
OWN - NLM
STAT- In-Process
LR  - 20180202
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - Circulating microRNA expression and their target genes in deep vein thrombosis: A
      systematic review and bioinformatics analysis.
PG  - e9330
LID - 10.1097/MD.0000000000009330 [doi]
AB  - BACKGROUND: Clinically, D-dimer is the only established biomarker for the
      diagnosis of deep vein thrombosis (DVT). However, low specificity discounts its
      diagnostic value. Several publications have illustrated the differentially
      expressed circulating microRNAs (miRNAs) and their potential diagnostic values
      for DVT patients. Therefore, we systematically evaluated present researches and
      further performed bioinformatics analysis, to provide new insights into the
      diagnosis and underlying mechanisms of miRNAs in DVT. METHODS: Databases PubMed, 
      Web of Science, and Embase were searched from January 2000 to April 2017.
      Articles on circulating miRNAs expression in DVT were retrieved and reference
      lists were handpicked. Bioinformatics analysis was conducted for further
      evaluation. RESULTS: Eventually, the eligibility criteria for inclusion in this
      study were met by 3 articles, which consisted of 13 specially expressed miRNAs
      and 149 putative target genes. Two representative KEGG pathways, vascular
      endothelial growth factor and phosphatidylinositol 3'-kinase (PI3K)-Akt signaling
      pathway, seemed to participate in the regulatory network of thrombosis.
      CONCLUSIONS: Despite the potential diagnostic value and regulation effect, the
      results of circulating miRNAs used as biomarkers for DVT are not so encouraging. 
      More in-depth and larger sample investigations are needed to explore the
      diagnostic and therapeutic values of miRNAs for DVT.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Jiang, Zhiyun
AU  - Jiang Z
AD  - Department of Clinical Laboratory, the First Affiliated Hospital of Zhengzhou
      University, Zhengzhou, Henan, China.
FAU - Ma, Junfen
AU  - Ma J
FAU - Wang, Qian
AU  - Wang Q
FAU - Wu, Fan
AU  - Wu F
FAU - Ping, Jiedan
AU  - Ping J
FAU - Ming, Liang
AU  - Ming L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2018/02/03 06:00
MHDA- 2018/02/03 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/03 06:00 [medline]
AID - 10.1097/MD.0000000000009330 [doi]
AID - 00005792-201712150-00152 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9330. doi: 10.1097/MD.0000000000009330.