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Plasma endothelin-1-related peptides as the prognostic biomarkers for heart failure: A PRISMA-compliant meta-analysis.

Abstract Most studies reported that high plasma endothelin-1 (ET-1), big ET-1, and C-terminal proET-1 (CT-proET-1) were correlated with poor prognosis of heart failure (HF). However, available evidence remains controversial. To help solve the debate, we collected all the available studies and performed a meta-analysis.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390406
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - Plasma endothelin-1-related peptides as the prognostic biomarkers for heart
      failure: A PRISMA-compliant meta-analysis.
PG  - e9342
LID - 10.1097/MD.0000000000009342 [doi]
AB  - BACKGROUND: Most studies reported that high plasma endothelin-1 (ET-1), big ET-1,
      and C-terminal proET-1 (CT-proET-1) were correlated with poor prognosis of heart 
      failure (HF). However, available evidence remains controversial. To help solve
      the debate, we collected all the available studies and performed a meta-analysis.
      METHODS: We searched the databases covering Embase, PubMed, Ovid, and Web of
      Science on June 28, 2017. The hazard ratio (HR) or risk ratio (RR) and its 95%
      confidence intervals (CIs) were collected and calculated by use of a
      random-effect model. Heterogeneity was assessed by Cochran's Q test, and
      publication bias was assessed by funnel plots with Egger's and Begg's linear
      regression test. RESULTS: Thirty-two studies with 18,497 patients were included
      in the analysis. Results showed that circulating ET-1, big ET-1, and CT-proET-1
      were positively correlated with high risk of adverse outcomes, with pooled RRs
      (95% CIs) of 2.22 (1.82-2.71, P < .001), 2.47 (1.93-3.17, P < .001), and 2.27
      (1.57-3.29, P < .001), respectively. In the subgroup of death as primary outcome,
      the pooled RRs (95% CIs) were 2.13 (1.68-2.70, P < .001), 2.55 (1.82-3.57, P <
      .001), and 2.02 (1.39-2.92, P < .001) for ET-1, big ET-1, and CT-proET-1,
      respectively. No significant publication bias was observed in this study.
      CONCLUSION: Our meta-analysis provided evidence that increased plasma levels of
      ET-1, big ET-1, and CT-proET-1 were associated with poor prognosis or mortality
      for HF populations.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Zhang, Cheng-Lin
AU  - Zhang CL
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Molecular
      Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors
      Research, Ministry of Education.
FAU - Xie, Shang
AU  - Xie S
AD  - Department of Oral and Maxillofacial Surgery, Peking University School and
      Hospital of Stomatology.
FAU - Qiao, Xue
AU  - Qiao X
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Molecular
      Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors
      Research, Ministry of Education.
FAU - An, Yuan-Ming
AU  - An YM
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Molecular
      Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors
      Research, Ministry of Education.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Molecular
      Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors
      Research, Ministry of Education.
FAU - Li, Li
AU  - Li L
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Molecular
      Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors
      Research, Ministry of Education.
FAU - Guo, Xiao-Bin
AU  - Guo XB
AD  - Department of Geriatrics, Peking University Third Hospital, Beijing, China.
FAU - Zhang, Fu-Chun
AU  - Zhang FC
AD  - Department of Geriatrics, Peking University Third Hospital, Beijing, China.
FAU - Wu, Li-Ling
AU  - Wu LL
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Molecular
      Cardiovascular Science, Beijing Key Laboratory of Cardiovascular Receptors
      Research, Ministry of Education.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 0 (Endothelin-1)
RN  - 0 (Peptide Fragments)
RN  - 0 (Protein Precursors)
RN  - 0 (proendothelin 1)
SB  - AIM
SB  - IM
MH  - Biomarkers/*blood
MH  - Endothelin-1/*blood
MH  - Heart Failure/*blood
MH  - Humans
MH  - Peptide Fragments/blood
MH  - Prognosis
MH  - Protein Precursors/blood
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009342 [doi]
AID - 00005792-201712150-00156 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9342. doi: 10.1097/MD.0000000000009342.