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The early examination of combined serum and imaging data under flexible fiberoptic bronchoscopy as a novel predictor for refractory Mycoplasma pneumoniae pneumonia diagnosis.

Abstract The treatment role of flexible bronchoscopy (FOB) for pediatric refractory Mycoplasma pneumoniae pneumonia (RMPP) has been well documented. Besides, the application indication of FOB is also studied in patients with general MPP (GMPP), especially in those with large pulmonary lesions. This study was designed to examine the diagnostic value of bronchoscopic features for RMPP.The FOB and bronchoalveolar lavage (BAL) were adopted for pediatric patients who showed clinical and radiograph indications. On the basis of the final diagnosis on discharge, patients were divided into general and refractory MPP groups. The clinical, laboratory, and bronchoscopic imaging features were retrospectively investigated between these 2 groups.From June 2012 to May 2014, a total of 62 RMPP and 101 GMPP patients were treated with therapeutic bronchoscopy. The comparison analysis showed that the CRP, HBDH, LDH were significantly different between RMPP and GMPP groups (all P < .001). In the bronchoscopic imaging, the mucus plug was significantly more commonly seen in the RMPP group (P < .001). Receiver operating characteristic (ROC) analysis revealed that the combined serum, clinical, and FOB imaging data possessed greater specificity and sensitivity than serum and clinical data alone.Our data suggest that the combined serum, clinical, and bronchoscopic imaging data might serve as a promising predictor for early RMPP diagnosis for pediatric patients with large pulmonary lesions.
PMID
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Authors

Mayor MeshTerms

Early Diagnosis

Keywords
Journal Title medicine
Publication Year Start




PMID- 29390413
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 50
DP  - 2017 Dec
TI  - The early examination of combined serum and imaging data under flexible
      fiberoptic bronchoscopy as a novel predictor for refractory Mycoplasma pneumoniae
      pneumonia diagnosis.
PG  - e9364
LID - 10.1097/MD.0000000000009364 [doi]
AB  - The treatment role of flexible bronchoscopy (FOB) for pediatric refractory
      Mycoplasma pneumoniae pneumonia (RMPP) has been well documented. Besides, the
      application indication of FOB is also studied in patients with general MPP
      (GMPP), especially in those with large pulmonary lesions. This study was designed
      to examine the diagnostic value of bronchoscopic features for RMPP.The FOB and
      bronchoalveolar lavage (BAL) were adopted for pediatric patients who showed
      clinical and radiograph indications. On the basis of the final diagnosis on
      discharge, patients were divided into general and refractory MPP groups. The
      clinical, laboratory, and bronchoscopic imaging features were retrospectively
      investigated between these 2 groups.From June 2012 to May 2014, a total of 62
      RMPP and 101 GMPP patients were treated with therapeutic bronchoscopy. The
      comparison analysis showed that the CRP, HBDH, LDH were significantly different
      between RMPP and GMPP groups (all P &lt; .001). In the bronchoscopic imaging, the
      mucus plug was significantly more commonly seen in the RMPP group (P &lt; .001).
      Receiver operating characteristic (ROC) analysis revealed that the combined
      serum, clinical, and FOB imaging data possessed greater specificity and
      sensitivity than serum and clinical data alone.Our data suggest that the combined
      serum, clinical, and bronchoscopic imaging data might serve as a promising
      predictor for early RMPP diagnosis for pediatric patients with large pulmonary
      lesions.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Wang, Le
AU  - Wang L
AD  - Institute of Pediatric Research.
FAU - Lu, Sukun
AU  - Lu S
AD  - No.2 Department of Respiratory.
FAU - Feng, Zhishan
AU  - Feng Z
AD  - Institute of Pediatric Research.
FAU - Li, Lanfeng
AU  - Li L
AD  - Department of Nursing, Children's Hospital of Hebei Province, Shijiazhuang,
      China.
FAU - Niu, Bo
AU  - Niu B
AD  - No.2 Department of Respiratory.
FAU - Shuai, Jinfeng
AU  - Shuai J
AD  - No.2 Department of Respiratory.
FAU - Cao, Lijie
AU  - Cao L
AD  - No.2 Department of Respiratory.
FAU - Li, Guixia
AU  - Li G
AD  - Institute of Pediatric Research.
AD  - Department of Laboratory Medicine.
FAU - Liu, Jianhua
AU  - Liu J
AD  - No.2 Department of Respiratory.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
SB  - AIM
SB  - IM
MH  - Agglutination Tests
MH  - Biomarkers/blood
MH  - Bronchoalveolar Lavage
MH  - Bronchoscopy
MH  - Child, Preschool
MH  - Diagnosis, Differential
MH  - *Early Diagnosis
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Pneumonia, Mycoplasma/*diagnosis/microbiology
MH  - Predictive Value of Tests
MH  - Real-Time Polymerase Chain Reaction
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
MH  - Young Adult
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009364 [doi]
AID - 00005792-201712150-00163 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(50):e9364. doi: 10.1097/MD.0000000000009364.