Diabetes mellitus is a risk factor for low bone mass-related fractures: A meta-analysis of cohort studies.
|Abstract||Diabetes mellitus (DM) is inconsistently associated with the risk of low bone mass-related fractures (LBMF). This study aimed to summarize available cohort studies regarding the strength of association between type 2 diabetes mellitus (T2DM) and LBMF.|
Fracture risk and healthcare resource utilization and costs among osteoporosis patients with type 2 diabetes mellitus and without diabetes mellitus in Japan: retrospective analysis of a hospital claims database.
|Publication Year Start||2018-01-01|
PMID- 29390417 OWN - NLM STAT- MEDLINE DCOM- 20180213 LR - 20180213 IS - 1536-5964 (Electronic) IS - 0025-7974 (Linking) VI - 96 IP - 51 DP - 2017 Dec TI - Diabetes mellitus is a risk factor for low bone mass-related fractures: A meta-analysis of cohort studies. PG - e8811 LID - 10.1097/MD.0000000000008811 [doi] AB - BACKGROUND: Diabetes mellitus (DM) is inconsistently associated with the risk of low bone mass-related fractures (LBMF). This study aimed to summarize available cohort studies regarding the strength of association between type 2 diabetes mellitus (T2DM) and LBMF. METHODS: Electronic searches of PubMed, Embase, and the Cochrane Library were performed to identify studies through April 2016. Cohort studies that reported effect estimates with 95% confidence intervals (CIs) of LBMF for T2DM and control comparison were included. RESULTS: The summary relative risks (RRs) for T2DM versus non-T2DM were associated with a higher risk of LBMF (RR: 1.24; 95% CI: 1.09-1.41; P = .001). Further, women with T2DM showed a harmful impact on the incidence of LBMF (RR: 1.19; 95% CI: 1.04-1.36; P = .010). However, in men, T2DM showed no significant impact on the risk of LBMF (RR: 1.14; 95% CI: 0.93-1.39; P = .215). Furthermore, the summary results suggested an association between T2DM and LBMF in studies that reported hazard ratio (HR) as an effect estimate in total cohorts (HR: 1.31; 95% CI: 1.17-1.46; P < .001), men (HR: 1.26; 95% CI: 1.11-1.43; P < .001), and women (HR: 1.32; 95% CI: 1.16-1.50; P < .001). However, these significant associations were not observed in studies that reported RR/odds ratio as an effect estimate. CONCLUSIONS: The present meta-analysis confirmed that T2DM was associated with an increased prevalence of LBMF compared with non-T2DM. CI - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved. FAU - Ni, Yu AU - Ni Y AD - Department of Orthopedics, Beijing Huaxin Hospital, The First Hospital of Tsinghua University. FAU - Fan, Dongwei AU - Fan D AD - Department of Orthopedics, Peking University Third Hospital, Beijing, China. LA - eng PT - Journal Article PT - Meta-Analysis PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - AIM SB - IM MH - Body Mass Index MH - Cohort Studies MH - *Diabetes Mellitus, Type 2 MH - Humans MH - Osteoporotic Fractures/*epidemiology/etiology MH - Prevalence MH - Risk Factors PMC - PMC5758119 EDAT- 2018/02/03 06:00 MHDA- 2018/02/14 06:00 CRDT- 2018/02/03 06:00 PHST- 2018/02/03 06:00 [entrez] PHST- 2018/02/03 06:00 [pubmed] PHST- 2018/02/14 06:00 [medline] AID - 10.1097/MD.0000000000008811 [doi] AID - 00005792-201712220-00004 [pii] PST - ppublish SO - Medicine (Baltimore). 2017 Dec;96(51):e8811. doi: 10.1097/MD.0000000000008811.