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Survival time and prognostic factors of patients with initial noncurative colorectal liver metastases.

Abstract The true survival benefit of different curative strategies involving type of operative procedure and timing for patients with initial noncurative colorectal liver metastases remains uncertain. The goal of this study was to examine the effect of primary tumor resection on patients' survival and to clarify the predictive factors related to overall survival (OS).This was a retrospective study that included 219 patients with initial noncurative colorectal liver metastases without extrahepatic disease. The clinicopathological characteristics of patients and their survival were examined. Survival analysis was performed using the Kaplan-Meier method. All variables associated with P <.05 in univariate analysis were included in multivariate analysis using a Cox proportional-hazard regression model.The 1-, 3-, 5-year OS rates of patients with simultaneous liver resection were 79.1%, 39.1%, and 28.4%, respectively, and those of patients with staged liver resection were 83.3%, 46.7%, and 36.8%, respectively (P = .380). The 1-, 3-, 5-year OS rates of patients with primary tumor resection were 57.0%, 18.2%, and 12.3%, respectively, while for the patients without primary tumor resection were 38.9%, 5.6%, and 0%, respectively (P = .012). Independent prognostic factors for OS were carbohydrate antigen19-9, primary tumor resection, tumor differentiation, and adjuvant chemotherapy.No difference in OS was observed between simultaneous liver resection and staged liver resection, while primary tumor resection was beneficial to noncurative colorectal liver metastases.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390420
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20180213
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 51
DP  - 2017 Dec
TI  - Survival time and prognostic factors of patients with initial noncurative
      colorectal liver metastases.
PG  - e8831
LID - 10.1097/MD.0000000000008831 [doi]
AB  - The true survival benefit of different curative strategies involving type of
      operative procedure and timing for patients with initial noncurative colorectal
      liver metastases remains uncertain. The goal of this study was to examine the
      effect of primary tumor resection on patients' survival and to clarify the
      predictive factors related to overall survival (OS).This was a retrospective
      study that included 219 patients with initial noncurative colorectal liver
      metastases without extrahepatic disease. The clinicopathological characteristics 
      of patients and their survival were examined. Survival analysis was performed
      using the Kaplan-Meier method. All variables associated with P &lt;.05 in univariate
      analysis were included in multivariate analysis using a Cox proportional-hazard
      regression model.The 1-, 3-, 5-year OS rates of patients with simultaneous liver 
      resection were 79.1%, 39.1%, and 28.4%, respectively, and those of patients with 
      staged liver resection were 83.3%, 46.7%, and 36.8%, respectively (P = .380). The
      1-, 3-, 5-year OS rates of patients with primary tumor resection were 57.0%,
      18.2%, and 12.3%, respectively, while for the patients without primary tumor
      resection were 38.9%, 5.6%, and 0%, respectively (P = .012). Independent
      prognostic factors for OS were carbohydrate antigen19-9, primary tumor resection,
      tumor differentiation, and adjuvant chemotherapy.No difference in OS was observed
      between simultaneous liver resection and staged liver resection, while primary
      tumor resection was beneficial to noncurative colorectal liver metastases.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Liu, Qizhi
AU  - Liu Q
AD  - Department of Colorectal Surgery, Changhai Hospital, Second Military Medical
      University.
FAU - Hao, Liqiang
AU  - Hao L
AD  - Department of Colorectal Surgery, Changhai Hospital, Second Military Medical
      University.
FAU - Lou, Zheng
AU  - Lou Z
AD  - Department of Colorectal Surgery, Changhai Hospital, Second Military Medical
      University.
FAU - Gao, Xianhua
AU  - Gao X
AD  - Department of Colorectal Surgery, Changhai Hospital, Second Military Medical
      University.
FAU - Gong, Haifeng
AU  - Gong H
AD  - Department of Colorectal Surgery, Changhai Hospital, Second Military Medical
      University.
FAU - Hong, Yonggang
AU  - Hong Y
AD  - Department of Colorectal Surgery, Changhai Hospital, Second Military Medical
      University.
FAU - Fu, Chuangang
AU  - Fu C
AD  - Department of Colorectal Surgery, Shanghai East Hospital, Tongji University
      School of Medicine, Shanghai, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Colorectal Surgery, Changhai Hospital, Second Military Medical
      University.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adenocarcinoma/diagnostic imaging/*mortality/secondary/surgery
MH  - China
MH  - Colorectal Neoplasms/*mortality/pathology
MH  - Combined Modality Therapy
MH  - Female
MH  - Hepatectomy
MH  - Humans
MH  - Liver Neoplasms/diagnostic imaging/*mortality/secondary/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Tomography, X-Ray Computed
PMC - PMC5758122
EDAT- 2018/02/03 06:00
MHDA- 2018/02/14 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
AID - 10.1097/MD.0000000000008831 [doi]
AID - 00005792-201712220-00007 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(51):e8831. doi: 10.1097/MD.0000000000008831.