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PMID- 29390564
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 51
DP  - 2017 Dec
TI  - The associations of stroke, transient ischemic attack, and/or stroke-related
      recurrent vascular events with Lipoprotein-associated phospholipase A2: A
      systematic review and meta-analysis.
PG  - e9413
LID - 10.1097/MD.0000000000009413 [doi]
AB  - BACKGROUND: Studies on stroke and lipoprotein-associated phospholipase A2
      (Lp-PLA2) have produced conflicting results. OBJECTIVE: The aim of the study was 
      to assess the associations of Lp-PLA2 levels (mass and activity) with recurrent
      vascular events in patients with transient ischemic attack (TIA) and/or first
      ischemic stroke and with stroke in the general population. METHODS: The MEDLINE, 
      Embase, the Cochrane Library, Web of Science, Science Direct, China National
      Knowledge Infrastructure, China Biology Medical Disc (CBMdisc), and WanFang were 
      searched for prospective observational studies reported until January 2017.
      Eligible studies reported Lp-PLA2 levels and adjusted risk estimates of recurrent
      vascular events and/or stroke. Risk ratio (RR) with corresponding 95% confidence 
      intervals (CIs) were used to express the pooled data in a random-effects model.
      RESULTS: A total of 11 studies that comprised 20,284 participants (4,045 were TIA
      and/or first ischemic stroke patients and 16,239 were residents in general
      population) were identified, which reported either Lp-PLA2 mass levels (4
      studies) or Lp-PLA2 activity levels (10 studies). The pooled RR of recurrent
      vascular events (467 cases) in TIA and/or first ischemic group was 2.24 (95% CI, 
      1.33-3.78), whereas the pooled RR of stroke (1604 cases) in the general
      population was 1.47 (95% CI, 1.10-1.97). The pooled RRs of Lp-PLA2 mass and
      activity levels with the risk of stroke in the general population were 1.69 (95% 
      CI, 1.03-2.79) and 1.28 (95% CI, 0.88-1.85), respectively. CONCLUSIONS: In
      patients with TIA and first ischemic stroke, elevated Lp-PLA2 activity levels
      were associated with recurrent vascular events. And in the general population
      elevated Lp-PLA2 levels were associated with the risk of stroke, although the
      association between Lp-PLA2 activity levels and the risk of stroke was less
      profound compared with the corresponding association of stroke risk with the
      Lp-PLA2 mass levels.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Tian, Ye
AU  - Tian Y
AD  - Department of Neurology, The Second Hospital of Hebei Medical University.
FAU - Jia, Huan
AU  - Jia H
AD  - Department of Neurology, The Second Hospital of Hebei Medical University.
FAU - Li, Sichen
AU  - Li S
AD  - Department of Neurology, The Second Hospital of Hebei Medical University.
FAU - Wu, Yanmin
AU  - Wu Y
AD  - Department of Neurology, The Second Hospital of Hebei Medical University.
FAU - Guo, Li
AU  - Guo L
AD  - Department of Neurology, The Second Hospital of Hebei Medical University.
AD  - Key Laboratory of Hebei Neurology, Shijiazhuang, Hebei, China.
FAU - Tan, Guojun
AU  - Tan G
AD  - Department of Neurology, The Second Hospital of Hebei Medical University.
AD  - Key Laboratory of Hebei Neurology, Shijiazhuang, Hebei, China.
FAU - Li, Bin
AU  - Li B
AD  - Department of Neurology, The Second Hospital of Hebei Medical University.
AD  - Key Laboratory of Hebei Neurology, Shijiazhuang, Hebei, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase)
SB  - AIM
SB  - IM
MH  - 1-Alkyl-2-acetylglycerophosphocholine Esterase/*blood
MH  - Humans
MH  - Ischemic Attack, Transient/*blood
MH  - Recurrence
MH  - Stroke/*blood/complications
PMC - PMC5758266
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009413 [doi]
AID - 00005792-201712220-00151 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(51):e9413. doi: 10.1097/MD.0000000000009413.