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Association between MDR1 C3435T polymorphism and colorectal cancer risk: A meta-analysis.

Abstract The multidrug resistance gene 1(MDR1) C3435T polymorphism has been reported to be associated with colorectal cancer (CRC) risk in Asians, however the results were inconsistent. Thus, we performed a meta-analysis to generate large-scale evidence on the association between C3435T polymorphism and CRC risk in Asian populations.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29390571
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 51
DP  - 2017 Dec
TI  - Association between MDR1 C3435T polymorphism and colorectal cancer risk: A
      meta-analysis.
PG  - e9428
LID - 10.1097/MD.0000000000009428 [doi]
AB  - BACKGROUND: The multidrug resistance gene 1(MDR1) C3435T polymorphism has been
      reported to be associated with colorectal cancer (CRC) risk in Asians, however
      the results were inconsistent. Thus, we performed a meta-analysis to generate
      large-scale evidence on the association between C3435T polymorphism and CRC risk 
      in Asian populations. METHODS: The PubMed, Web of Science, Embase, CNKI, and
      Chinese Biomedicine databases were searched up to January 15, 2017. The odd
      ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by a
      fixed-effects or random-effects model. Sensitivity and cumulative meta-analysis
      were also performed. RESULTS: A total of 7 studies involving 4818 individuals
      were included in this pooled-analysis. The results suggested that persons
      carrying a T allele at the C3435T polymorphism had a significantly decreased risk
      of CRC in Asian population (T vs C: OR = 0.897, 95%CI = 0.826-0.975, P = .01),
      and the significant association was also observed in another 2 genetic models (TT
      vs CC: OR = 0.721, 95%CI = 0.605-0.861, P < .001; TT vs TC+CC: OR = 0.679, 95%CI 
      = 0.579-0.795, P < .001). Moreover, the results of sensitivity and cumulative
      meta-analysis indicated the stable of our results. Finally, funnel plot and
      Egger's test showed no evidence of publication bias. CONCLUSIONS: In summary,
      this meta-analysis provided evidence that MDR1 C3435T polymorphism is associated 
      with a decreased risk of CRC in Asian population.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Jin, Shan-Shan
AU  - Jin SS
AD  - Department of Oncology.
FAU - Song, Wei-Juan
AU  - Song WJ
AD  - Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing
      Medical University, Nanjing, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (ABCB1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Sub-Family B)
SB  - AIM
SB  - IM
MH  - ATP Binding Cassette Transporter, Sub-Family B/genetics
MH  - Asian Continental Ancestry Group/genetics/statistics & numerical data
MH  - Colorectal Neoplasms/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Risk Factors
PMC - PMC5758273
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009428 [doi]
AID - 00005792-201712220-00158 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(51):e9428. doi: 10.1097/MD.0000000000009428.