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Endoscopic traversability in patients with locally advanced esophageal squamous cell carcinoma: Is it a significant prognostic factor?

Abstract The purpose of this study was to evaluate the prognostic impact of endoscopic traversability in patients with locally advanced esophageal squamous cell carcinoma.This retrospective study was based on medical records from a single tertiary medical center. The records of 317 patients with esophageal squamous cell carcinoma treated with surgery or definitive chemoradiotherapy (CRT) between January 2009 and March 2016 were reviewed. Finally, we retrieved the data on 168 consecutive patients. These 168 patients were divided into 2 groups based on their endoscopic traversability findings: Group A (the endoscope traversable group), and Group B (the endoscope non-traversable group). We then retrospectively compared the clinical characteristics of these 2 groups.The endoscope non-traversable group (Group B) revealed an advanced clinical stage, a poor Eastern Cooperative Oncology Group (ECOG) score, a lower serum albumin level, a higher rate of requirement for esophageal stent insertion and definitive CRT as initial treatment than the endoscope traversable group (Group A). Patients with endoscope traversable cancer showed a significantly higher 3-year overall survival and 3-year relapse-free survival than patients who were endoscope non-traversable (53.8% vs 17.3%, P < .001 and 71.1% vs 45.3%, P = .003, respectively). Upon multivariate analysis of patients with locally advanced esophageal squamous cell carcinoma treated with definitive CRT, the serum albumin level <3.5 g/dL and endoscopic non-traversability were significant negative factors of survival.Endoscopic traversability in patients with locally advanced esophageal squamous cell carcinoma treated with definitive CRT is a significant prognostic factor.
PMID
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Authors

Mayor MeshTerms

Esophagoscopy

Keywords
Journal Title medicine
Publication Year Start




PMID- 29390576
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 51
DP  - 2017 Dec
TI  - Endoscopic traversability in patients with locally advanced esophageal squamous
      cell carcinoma: Is it a significant prognostic factor?
PG  - e9441
LID - 10.1097/MD.0000000000009441 [doi]
AB  - The purpose of this study was to evaluate the prognostic impact of endoscopic
      traversability in patients with locally advanced esophageal squamous cell
      carcinoma.This retrospective study was based on medical records from a single
      tertiary medical center. The records of 317 patients with esophageal squamous
      cell carcinoma treated with surgery or definitive chemoradiotherapy (CRT) between
      January 2009 and March 2016 were reviewed. Finally, we retrieved the data on 168 
      consecutive patients. These 168 patients were divided into 2 groups based on
      their endoscopic traversability findings: Group A (the endoscope traversable
      group), and Group B (the endoscope non-traversable group). We then
      retrospectively compared the clinical characteristics of these 2 groups.The
      endoscope non-traversable group (Group B) revealed an advanced clinical stage, a 
      poor Eastern Cooperative Oncology Group (ECOG) score, a lower serum albumin
      level, a higher rate of requirement for esophageal stent insertion and definitive
      CRT as initial treatment than the endoscope traversable group (Group A). Patients
      with endoscope traversable cancer showed a significantly higher 3-year overall
      survival and 3-year relapse-free survival than patients who were endoscope
      non-traversable (53.8% vs 17.3%, P &lt; .001 and 71.1% vs 45.3%, P = .003,
      respectively). Upon multivariate analysis of patients with locally advanced
      esophageal squamous cell carcinoma treated with definitive CRT, the serum albumin
      level &lt;3.5 g/dL and endoscopic non-traversability were significant negative
      factors of survival.Endoscopic traversability in patients with locally advanced
      esophageal squamous cell carcinoma treated with definitive CRT is a significant
      prognostic factor.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Shin, Hae Jin
AU  - Shin HJ
AD  - Division of Gastroenterology, Department of Internal Medicine, Aerospace Medical 
      Center, Republic of Korea Air Force, Cheongwon-gun, Chungcheongbuk-do.
FAU - Moon, Hee Seok
AU  - Moon HS
AD  - Division of Gastroenterology, Department of Internal Medicine, Chungnam National 
      University Hospital, Chungnam National University School of Medicine, Daejeon,
      Republic of Korea.
FAU - Kang, Sun Hyung
AU  - Kang SH
AD  - Division of Gastroenterology, Department of Internal Medicine, Chungnam National 
      University Hospital, Chungnam National University School of Medicine, Daejeon,
      Republic of Korea.
FAU - Sung, Jae Kyu
AU  - Sung JK
AD  - Division of Gastroenterology, Department of Internal Medicine, Chungnam National 
      University Hospital, Chungnam National University School of Medicine, Daejeon,
      Republic of Korea.
FAU - Jeong, Hyun Yong
AU  - Jeong HY
AD  - Division of Gastroenterology, Department of Internal Medicine, Chungnam National 
      University Hospital, Chungnam National University School of Medicine, Daejeon,
      Republic of Korea.
FAU - Kim, Seok Hyun
AU  - Kim SH
AD  - Division of Gastroenterology, Department of Internal Medicine, Chungnam National 
      University Hospital, Chungnam National University School of Medicine, Daejeon,
      Republic of Korea.
FAU - Lee, Byung Seok
AU  - Lee BS
AD  - Division of Gastroenterology, Department of Internal Medicine, Chungnam National 
      University Hospital, Chungnam National University School of Medicine, Daejeon,
      Republic of Korea.
FAU - Kim, Ju Seok
AU  - Kim JS
AD  - Division of Gastroenterology, Department of Internal Medicine, Chungnam National 
      University Hospital, Chungnam National University School of Medicine, Daejeon,
      Republic of Korea.
FAU - Yun, Gee Young
AU  - Yun GY
AD  - Division of Gastroenterology, Department of Internal Medicine, Chungnam National 
      University Hospital, Chungnam National University School of Medicine, Daejeon,
      Republic of Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - Esophageal Squamous Cell Carcinoma
SB  - AIM
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*diagnosis/mortality/pathology
MH  - Esophageal Neoplasms/*diagnosis/mortality/pathology
MH  - *Esophagoscopy
MH  - Female
MH  - Humans
MH  - Male
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Analysis
PMC - PMC5758278
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009441 [doi]
AID - 00005792-201712220-00163 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(51):e9441. doi: 10.1097/MD.0000000000009441.