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PMID- 29390586
DCOM- 20180212
LR  - 20180212
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 51
DP  - 2017 Dec
TI  - A case report of phosphaturic mesenchymal tumor-induced osteomalacia.
PG  - e9470
LID - 10.1097/MD.0000000000009470 [doi]
AB  - RATIONALE: Tumor-induced osteomalacia (TIO) is a rare and often misdiagnosed
      syndrome. Surgical resection is currently the first line treatment for TIO.
      PATIENT CONCERNS: Here we report the case of a 49-year-old woman presented with
      intermittent pain in the right chest and bilateral hip that had persisted for
      over two years. DIAGNOSES: She was diagnosed of TIO caused by a phosphaturic
      mesenchymal tumor based on the following examinations. Laboratory tests revealed 
      high serum alkaline phosphatase, high urinary phosphorus, hypophosphatemia and
      normal serum calcium levels. 18-FDG PET/CT indicated a systemic multi-site
      symmetrical pseudo fracture and a tumor in the 7th right rib. INTERVENTIONS:
      Curettage of the tumor was performed, and pathological analysis also confirmed
      our diagnoses as a phosphaturic mesenchymal tumor. OUTCOMES: At seven months
      post-surgery, the symptoms were relieved, proximal muscle strength was improved
      and serum levels of phosphorus and alkaline phosphatase normalized. The bilateral
      femoral neck and bilateral pubic bone fractures were blurred in the pelvic plain 
      X-ray, suggesting that the fracture was healing. LESSONS: This case report
      strengthened the importance of recognition of this rare disease to avoid delay of
      diagnosis and surgical removal of the causative tumor is recommended.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Wu, Weiqian
AU  - Wu W
AD  - Department of Orthopedics.
FAU - Wang, Chongyang
AU  - Wang C
AD  - Department of Respiration.
FAU - Ruan, Jianwei
AU  - Ruan J
AD  - Department of Orthopedics.
FAU - Chen, Feng
AU  - Chen F
AD  - Department of Orthopedics.
FAU - Li, Ningjun
AU  - Li N
AD  - Department of Pathology, Taizhou Municipal Hospital, Taizhou, Zhejiang, China.
FAU - Chen, Fanghu
AU  - Chen F
AD  - Department of Orthopedics.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - EC (Alkaline Phosphatase)
RN  - Oncogenic osteomalacia
SB  - IM
MH  - Alkaline Phosphatase/blood
MH  - Bone Neoplasms/*complications/diagnosis/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Hypophosphatemia, Familial/*etiology
MH  - Middle Aged
MH  - Neoplasms, Connective Tissue/*etiology
MH  - Osteomalacia/*etiology
MH  - Positron-Emission Tomography
PMC - PMC5758288
EDAT- 2018/02/03 06:00
MHDA- 2018/02/13 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
AID - 10.1097/MD.0000000000009470 [doi]
AID - 00005792-201712220-00173 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(51):e9470. doi: 10.1097/MD.0000000000009470.