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Relationship between matrilin-1 gene polymorphisms and mandibular retrognathism.

Abstract Mandibular retrognathism is a type of malocclusion that refers to an abnormal posterior position of the mandible as a result of a developmental abnormality. From the literature, it is evident that the mandibular growth pattern is determined by the intramembranous ossification of the mandibular body and endochondral ossification of the condyle. Matrilin-1 is a cartilage extracellular matrix protein, and matrilin-1 gene (MATN1) polymorphisms have been found to be involved in dental malocclusions of humans. In this study, we aimed to examine the association between MATN1 polymorphisms and the risk of mandibular retrognathism, in a case-control study with a South Indian population.
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Mayor MeshTerms
Keywords
Journal Title american journal of orthodontics and dentofacial orthopedics : official publication of the american association of orthodontists, its constituent societies, and the american board of orthodontics
Publication Year Start




PMID- 29407503
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20180213
IS  - 1097-6752 (Electronic)
IS  - 0889-5406 (Linking)
VI  - 153
IP  - 2
DP  - 2018 Feb
TI  - Relationship between matrilin-1 gene polymorphisms and mandibular retrognathism.
PG  - 255-261.e1
LID - S0889-5406(17)30847-8 [pii]
LID - 10.1016/j.ajodo.2017.06.023 [doi]
AB  - INTRODUCTION: Mandibular retrognathism is a type of malocclusion that refers to
      an abnormal posterior position of the mandible as a result of a developmental
      abnormality. From the literature, it is evident that the mandibular growth
      pattern is determined by the intramembranous ossification of the mandibular body 
      and endochondral ossification of the condyle. Matrilin-1 is a cartilage
      extracellular matrix protein, and matrilin-1 gene (MATN1) polymorphisms have been
      found to be involved in dental malocclusions of humans. In this study, we aimed
      to examine the association between MATN1 polymorphisms and the risk of mandibular
      retrognathism, in a case-control study with a South Indian population. METHODS:
      Eighty-one patients with mandibular retrognathism (SNB, <78 degrees ) and 71
      controls having an orthognathic mandible (SNB, 80 degrees +/- 2 degrees ) were
      recruited. In both the patient and control groups, subjects with an orthognathic 
      maxilla (SNA, 82 degrees +/- 2 degrees ) were included. Three single nucleotide
      polymorphisms of the MATN1 gene (rs1149048, rs1149042, and rs1065755) were
      genotyped using polymerase chain reaction-restriction fragment length
      polymorphism. The statistical association analysis was performed using the
      chi-square test. Pair-wise linkage disequilibrium was computed, and haplotypes
      were compared between subjects and controls. Nonparametric tests were used to
      compare cephalometric measurements between groups. RESULTS: No polymorphic site
      deviated from Hardy-Weinberg equilibrium in the controls. The rs1149042 genotypes
      and alleles were found to be associated with reduced risk of mandibular
      retrognathism. Furthermore, rs1149042 genotypes were associated with mandibular
      measurements (SNB and ANB). There was no strong and consistent linkage
      disequilibrium linkage disequilibrium across two different single nucleotide
      polymorphisms and haplotypes were not associated with mandibular retrognathism.
      CONCLUSIONS: The results of our study suggest an association between the MATN1
      gene polymorphisms and mandibular retrognathism.
CI  - Copyright (c) 2017 American Association of Orthodontists. Published by Elsevier
      Inc. All rights reserved.
FAU - Balkhande, Pranita B
AU  - Balkhande PB
AD  - Department of Orthodontics and Dentofacial Orthopaedics, Sri Ramachandra
      University, Porur, Chennai, India.
FAU - Lakkakula, Bhaskar V K S
AU  - Lakkakula BVKS
AD  - Sickle Cell Institute, Chhattisgarh, Raipur, India.
FAU - Chitharanjan, Arun B
AU  - Chitharanjan AB
AD  - Department of Orthodontics and Dentofacial Orthopaedics, Sri Ramachandra
      University, Porur, Chennai, India. Electronic address: [email protected]
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Orthod Dentofacial Orthop
JT  - American journal of orthodontics and dentofacial orthopedics : official
      publication of the American Association of Orthodontists, its constituent
      societies, and the American Board of Orthodontics
JID - 8610224
RN  - 0 (Matrilin Proteins)
SB  - D
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Genetic Association Studies
MH  - Humans
MH  - Male
MH  - Mandible/pathology
MH  - Matrilin Proteins/*genetics/physiology
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Retrognathia/*genetics/pathology
MH  - Young Adult
EDAT- 2018/02/07 06:00
MHDA- 2018/02/14 06:00
CRDT- 2018/02/07 06:00
PHST- 2016/06/01 00:00 [received]
PHST- 2017/06/01 00:00 [revised]
PHST- 2017/06/01 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
AID - S0889-5406(17)30847-8 [pii]
AID - 10.1016/j.ajodo.2017.06.023 [doi]
PST - ppublish
SO  - Am J Orthod Dentofacial Orthop. 2018 Feb;153(2):255-261.e1. doi:
      10.1016/j.ajodo.2017.06.023.