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Mechanisms underlying glucocorticoid resistance in chronic rhinosinusitis with nasal polyps.

Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease that occurs in the nasal and sinus mucosa, which is a common disease in otorhinolaryngology. At present, CRSwNP can be effectively treated by glucocorticoids (GC). GC binds to GC receptors in the nasal mucosa, affects the expression of inflammatory genes, inhibits the activation and action of eosinophils, T cell-associated inflammatory responses in nasal polyps, as well as tissue remodeling. However, there are some patients fall reponse to GC, so called GC resistance. The study suggests that the possible mechanism of CRSwNP GC resistance is mainly related to GC receptor abnormal, the role of cytokines and transcription factors, such as Th cells and IL-8. In addition, MAPK-related kinases and histone deacetylase in the GC signaling pathway also play important roles in the GC resistance process. This paper reviews the mechanism of GC treatment of CRSwNP, the mechanism of GC resistance and alternative treatment of GC.
PMID
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Authors

Mayor MeshTerms

Metabolism, Inborn Errors

Keywords

Glucocorticoids

Immunity

Nasal polyps

Journal Title zhonghua er bi yan hou tou jing wai ke za zhi = chinese journal of otorhinolaryngology head and neck surgery
Publication Year Start




PMID- 29429191
OWN - NLM
STAT- MEDLINE
DCOM- 20180307
LR  - 20180307
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 53
IP  - 2
DP  - 2018 Feb 7
TI  - [Mechanisms underlying glucocorticoid resistance in chronic rhinosinusitis with
      nasal polyps].
PG  - 154-160
LID - 10.3760/cma.j.issn.1673-0860.2018.02.017 [doi]
AB  - Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory
      disease that occurs in the nasal and sinus mucosa, which is a common disease in
      otorhinolaryngology. At present, CRSwNP can be effectively treated by
      glucocorticoids (GC). GC binds to GC receptors in the nasal mucosa, affects the
      expression of inflammatory genes, inhibits the activation and action of
      eosinophils, T cell-associated inflammatory responses in nasal polyps, as well as
      tissue remodeling. However, there are some patients fall reponse to GC, so called
      GC resistance. The study suggests that the possible mechanism of CRSwNP GC
      resistance is mainly related to GC receptor abnormal, the role of cytokines and
      transcription factors, such as Th cells and IL-8. In addition, MAPK-related
      kinases and histone deacetylase in the GC signaling pathway also play important
      roles in the GC resistance process. This paper reviews the mechanism of GC
      treatment of CRSwNP, the mechanism of GC resistance and alternative treatment of 
      GC.
FAU - Zhang, Y Y
AU  - Zhang YY
AD  - Deparment of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital,
      Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of
      Nasal Diseases, Beijing Institude of Otorhinolaryngology, Beijing 100005, China.
FAU - Lou, H F
AU  - Lou HF
AD  - Deparment of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital,
      Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of
      Nasal Diseases, Beijing Institude of Otorhinolaryngology, Beijing 100005, China.
FAU - Wang, C S
AU  - Wang CS
AD  - Deparment of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital,
      Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of
      Nasal Diseases, Beijing Institude of Otorhinolaryngology, Beijing 100005, China.
FAU - Zhang, L
AU  - Zhang L
AD  - Deparment of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital,
      Capital Medical University, Beijing 100730, China; Beijing Key Laboratory of
      Nasal Diseases, Beijing Institude of Otorhinolaryngology, Beijing 100005, China; 
      Department of Allergy, Beijing Tongren Hospital, Capital Medical University,
      Beijing 100730, China.
LA  - chi
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - 0 (Cytokines)
RN  - 0 (Glucocorticoids)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Transcription Factors)
RN  - Glucocorticoid Receptor Deficiency
SB  - IM
MH  - Chronic Disease
MH  - Cytokines/metabolism
MH  - Drug Resistance
MH  - Glucocorticoids/metabolism/*therapeutic use
MH  - Humans
MH  - *Metabolism, Inborn Errors
MH  - Nasal Mucosa/metabolism
MH  - Nasal Polyps/complications/*drug therapy
MH  - Receptors, Glucocorticoid/*deficiency
MH  - Rhinitis/complications/*drug therapy
MH  - Signal Transduction
MH  - Sinusitis/complications/*drug therapy
MH  - Transcription Factors/metabolism
OTO - NOTNLM
OT  - Glucocorticoids
OT  - Immunity
OT  - Nasal polyps
EDAT- 2018/02/13 06:00
MHDA- 2018/03/08 06:00
CRDT- 2018/02/13 06:00
PHST- 2018/02/13 06:00 [entrez]
PHST- 2018/02/13 06:00 [pubmed]
PHST- 2018/03/08 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Feb 7;53(2):154-160.