PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 29443664
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20180301
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 378
IP  - 7
DP  - 2018 Feb 15
TI  - Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy.
PG  - 625-635
LID - 10.1056/NEJMoa1710504 [doi]
AB  - BACKGROUND: Nusinersen is an antisense oligonucleotide drug that modulates
      pre-messenger RNA splicing of the survival motor neuron 2 ( SMN2) gene. It has
      been developed for the treatment of spinal muscular atrophy (SMA). METHODS: We
      conducted a multicenter, double-blind, sham-controlled, phase 3 trial of
      nusinersen in 126 children with SMA who had symptom onset after 6 months of age. 
      The children were randomly assigned, in a 2:1 ratio, to undergo intrathecal
      administration of nusinersen at a dose of 12 mg (nusinersen group) or a sham
      procedure (control group) on days 1, 29, 85, and 274. The primary end point was
      the least-squares mean change from baseline in the Hammersmith Functional Motor
      Scale-Expanded (HFMSE) score at 15 months of treatment; HFMSE scores range from 0
      to 66, with higher scores indicating better motor function. Secondary end points 
      included the percentage of children with a clinically meaningful increase from
      baseline in the HFMSE score (>/=3 points), an outcome that indicates improvement 
      in at least two motor skills. RESULTS: In the prespecified interim analysis,
      there was a least-squares mean increase from baseline to month 15 in the HFMSE
      score in the nusinersen group (by 4.0 points) and a least-squares mean decrease
      in the control group (by -1.9 points), with a significant between-group
      difference favoring nusinersen (least-squares mean difference in change, 5.9
      points; 95% confidence interval, 3.7 to 8.1; P<0.001). This result prompted early
      termination of the trial. Results of the final analysis were consistent with
      results of the interim analysis. In the final analysis, 57% of the children in
      the nusinersen group as compared with 26% in the control group had an increase
      from baseline to month 15 in the HFMSE score of at least 3 points (P<0.001), and 
      the overall incidence of adverse events was similar in the nusinersen group and
      the control group (93% and 100%, respectively). CONCLUSIONS: Among children with 
      later-onset SMA, those who received nusinersen had significant and clinically
      meaningful improvement in motor function as compared with those in the control
      group. (Funded by Biogen and Ionis Pharmaceuticals; CHERISH ClinicalTrials.gov
      number, NCT02292537 .).
FAU - Mercuri, Eugenio
AU  - Mercuri E
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Darras, Basil T
AU  - Darras BT
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Chiriboga, Claudia A
AU  - Chiriboga CA
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Day, John W
AU  - Day JW
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Campbell, Craig
AU  - Campbell C
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Connolly, Anne M
AU  - Connolly AM
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Iannaccone, Susan T
AU  - Iannaccone ST
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Kirschner, Janbernd
AU  - Kirschner J
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Kuntz, Nancy L
AU  - Kuntz NL
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Saito, Kayoko
AU  - Saito K
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Shieh, Perry B
AU  - Shieh PB
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Tulinius, Mar
AU  - Tulinius M
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Mazzone, Elena S
AU  - Mazzone ES
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Montes, Jacqueline
AU  - Montes J
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Bishop, Kathie M
AU  - Bishop KM
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Yang, Qingqing
AU  - Yang Q
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Foster, Richard
AU  - Foster R
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Gheuens, Sarah
AU  - Gheuens S
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Bennett, C Frank
AU  - Bennett CF
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Farwell, Wildon
AU  - Farwell W
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Schneider, Eugene
AU  - Schneider E
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - De Vivo, Darryl C
AU  - De Vivo DC
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
FAU - Finkel, Richard S
AU  - Finkel RS
AD  - From the Department of Pediatric Neurology, Catholic University, Rome (E.M.,
      E.S.M.); the Department of Neurology, Boston Children's Hospital, Boston
      (B.T.D.), and Biogen, Cambridge (R.F., S.G., W.F.) - both in Massachusetts; the
      Departments of Neurology (C.A.C., J.M., D.C.D.), Pediatrics (C.A.C., D.C.D.), and
      Rehabilitation and Regenerative Medicine (J.M.), Columbia University Medical
      Center, New York; the Department of Neurology, Stanford School of Medicine,
      Stanford (J.W.D.), David Geffen School of Medicine at University of California,
      Los Angeles, Los Angeles (P.B.S.), and Ionis Pharmaceuticals, Carlsbad (K.M.B.,
      Q.Y., C.F.B., E.S.) - all in California; Children's Hospital-London Health
      Sciences Centre, London, ON, Canada (C.C.); the Department of Neurology,
      Washington University School of Medicine, St. Louis (A.M.C.); the Department of
      Pediatrics, University of Texas Southwestern Medical Center, Dallas (S.T.I.); the
      Department of Neuropediatrics and Muscle Disorders, Medical Center-University of 
      Freiburg, Faculty of Medicine, Freiburg, Germany (J.K.); the Department of
      Pediatrics, Ann and Robert H. Lurie Children's Hospital, Chicago (N.L.K.); the
      Institute of Medical Genetics and Department of Pediatrics, Tokyo Women's Medical
      University, Tokyo (K.S.); the Department of Pediatrics, Gothenburg University,
      Queen Silvia Children's Hospital, Gothenburg, Sweden (M.T.); and the Division of 
      Neurology, Department of Pediatrics, Nemours Children's Hospital, Orlando, FL
      (R.S.F.).
CN  - CHERISH Study Group
LA  - eng
SI  - ClinicalTrials.gov/NCT02292537
SI  - ClinicalTrials.gov/NCT02292537
PT  - Clinical Trial, Phase III
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (Oligonucleotides)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (nusinersen)
SB  - AIM
SB  - IM
MH  - Age of Onset
MH  - Child
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Infant
MH  - Injections, Spinal
MH  - Least-Squares Analysis
MH  - Male
MH  - Motor Skills
MH  - Oligonucleotides/adverse effects/*therapeutic use
MH  - Oligonucleotides, Antisense/adverse effects/*therapeutic use
MH  - Spinal Muscular Atrophies of Childhood/*drug therapy/physiopathology
IR  - Bradley WG
FIR - Bradley, Walter G
IR  - Kaufmann P
FIR - Kaufmann, Petra
IR  - Dickson PI
FIR - Dickson, Patricia I
IR  - Reingold SC
FIR - Reingold, Stephen C
IR  - Davis CS
FIR - Davis, Charles S
IR  - Arredondo K
FIR - Arredondo, Kristen
IR  - Castro D
FIR - Castro, Diana
IR  - Cowie M
FIR - Cowie, Margaret
IR  - Farrow-Gillespie A
FIR - Farrow-Gillespie, Alan
IR  - Hebert A
FIR - Hebert, Andrew
IR  - Kauk M
FIR - Kauk, Melissa
IR  - Miller N
FIR - Miller, Nancy
IR  - Nelson L
FIR - Nelson, Leslie
IR  - Spain T Jr
FIR - Spain, Thomas Jr
IR  - Cappell J
FIR - Cappell, Joshua
IR  - Constantinescu A
FIR - Constantinescu, Andrei
IR  - Cruz R
FIR - Cruz, Rosangel
IR  - Dastgir J
FIR - Dastgir, Jahannaz
IR  - Dunaway S
FIR - Dunaway, Sally
IR  - Engelstad K
FIR - Engelstad, Kristin
IR  - Khandji AG
FIR - Khandji, Alexander G
IR  - Kramer S
FIR - Kramer, Samantha
IR  - Marra J
FIR - Marra, Jonathan
IR  - Popolizio M
FIR - Popolizio, Molly
IR  - Salazar R
FIR - Salazar, Rachel
IR  - Weimer LH
FIR - Weimer, Louis H
IR  - Aziz-Zaman S
FIR - Aziz-Zaman, Sonya
IR  - LaMarca N
FIR - LaMarca, Nicole
IR  - Ghosh P
FIR - Ghosh, Partha
IR  - Al-Ghamdi F
FIR - Al-Ghamdi, Fouad
IR  - Liew W
FIR - Liew, Wendy
IR  - Graham R
FIR - Graham, Robert
IR  - Berde C
FIR - Berde, Charles
IR  - Sethna N
FIR - Sethna, Navil
IR  - Koka A
FIR - Koka, Anjali
IR  - Wang L
FIR - Wang, Luke
IR  - Laine R
FIR - Laine, Regina
IR  - Souris M
FIR - Souris, Michelle
IR  - Ordonez G
FIR - Ordonez, Grace
IR  - Harrington T
FIR - Harrington, Timothy
IR  - Szelag H
FIR - Szelag, Heather
IR  - Pasternak A
FIR - Pasternak, Amy
IR  - Mirek E
FIR - Mirek, Elizabeth
IR  - Quigley J
FIR - Quigley, Janet
IR  - Berry D
FIR - Berry, Debbie
IR  - Civitello M
FIR - Civitello, Matthew
IR  - Endsley JD
FIR - Endsley, Julie Duke
IR  - Eden C
FIR - Eden, Candace
IR  - Leon W
FIR - Leon, Wendy
IR  - O'Reardon K
FIR - O'Reardon, Kathleen
IR  - Sigurdardottir L
FIR - Sigurdardottir, Laufey
IR  - Johnson C
FIR - Johnson, Craig
IR  - Turner J
FIR - Turner, Jenna
IR  - Vega M
FIR - Vega, Melisa
IR  - Weber-Guzman F
FIR - Weber-Guzman, Fabiola
IR  - Zinn M
FIR - Zinn, Matthias
IR  - Tesi Rocha AC
FIR - Tesi Rocha, Ana Carolina
IR  - Watson K
FIR - Watson, Karolina
IR  - D'Souza G
FIR - D'Souza, Genevieve
IR  - Ramamurthi RJ
FIR - Ramamurthi, R J
IR  - Gee R
FIR - Gee, Richard
IR  - Kitsuwa-Lowe J
FIR - Kitsuwa-Lowe, Janis
IR  - Hagerman K
FIR - Hagerman, Katharine
IR  - Crasta S
FIR - Crasta, Sheela
IR  - Welsh L
FIR - Welsh, Lesly
IR  - Paulose S
FIR - Paulose, Shirley
IR  - McFall D
FIR - McFall, Danielle
IR  - Perez J
FIR - Perez, Jennifer
IR  - Patnaik S
FIR - Patnaik, Swetapadma
IR  - Sanjanwala B
FIR - Sanjanwala, Bharati
IR  - Sakamuri S
FIR - Sakamuri, Sarada
IR  - Proud C
FIR - Proud, Crystal
IR  - Purse BP
FIR - Purse, Bona Park
IR  - Duong TT
FIR - Duong, Trinh Tina
IR  - Sampson J
FIR - Sampson, Jacinda
IR  - Tennekoon G
FIR - Tennekoon, Gihan
IR  - Brandsema J
FIR - Brandsema, John
IR  - Glanzman A
FIR - Glanzman, Allan
IR  - Flickinger J
FIR - Flickinger, Jean
IR  - Toms M
FIR - Toms, Michele
IR  - Adang L
FIR - Adang, Laura
IR  - Stanford D
FIR - Stanford, Delores
IR  - Mayer O
FIR - Mayer, Oscar
IR  - Zigmont J
FIR - Zigmont, Joshua
IR  - Chadehumbe M
FIR - Chadehumbe, Madeline
IR  - Kichula E
FIR - Kichula, Elizabeth
IR  - Finanger E
FIR - Finanger, Erika
IR  - Russman B
FIR - Russman, Barry
IR  - Roberts C
FIR - Roberts, Colin
IR  - Frank A
FIR - Frank, Andrea
IR  - Benjamin D
FIR - Benjamin, Danielle
IR  - Zilke K
FIR - Zilke, Kirsten
IR  - Golumbek PT
FIR - Golumbek, Paul T
IR  - Zaidman CM
FIR - Zaidman, Craig M
IR  - Anand P
FIR - Anand, Pallavi
IR  - Gadeken R
FIR - Gadeken, Rebecca
IR  - Siener C
FIR - Siener, Catherine
IR  - Epstein L
FIR - Epstein, Leon
IR  - Krueger J
FIR - Krueger, Jena
IR  - Goldman S
FIR - Goldman, Stewart
IR  - Krosschell K
FIR - Krosschell, Kristin
IR  - Blomgren C
FIR - Blomgren, Colleen
IR  - Choi HW
FIR - Choi, Hyoung Won
IR  - Kurz J
FIR - Kurz, Jonathan
IR  - Parsons J
FIR - Parsons, Julie
IR  - Janas J
FIR - Janas, Joanne
IR  - Yang M
FIR - Yang, Michele
IR  - Ballard A
FIR - Ballard, Alison
IR  - Carry T
FIR - Carry, Terri
IR  - Shea S
FIR - Shea, Stephanie
IR  - Bielsky A
FIR - Bielsky, Alan
IR  - Booker K
FIR - Booker, Kaylee
IR  - Camuto A
FIR - Camuto, Alicia
IR  - Lord-Halvorson S
FIR - Lord-Halvorson, Sierra
IR  - Gibbons M
FIR - Gibbons, Melissa
IR  - Zimmerman C
FIR - Zimmerman, Carl
IR  - Allen V
FIR - Allen, Victoria
IR  - Fuhr P
FIR - Fuhr, Peter
IR  - Kelley C
FIR - Kelley, Carolyn
IR  - Johnson H
FIR - Johnson, Hannah
IR  - Tran V
FIR - Tran, Vi
IR  - VanderVeen G
FIR - VanderVeen, Gina
IR  - Fowler E
FIR - Fowler, Eileen
IR  - Parziale N
FIR - Parziale, Nicholas
IR  - Rao L
FIR - Rao, Lekha
IR  - Skura C
FIR - Skura, Christy
IR  - Shu F
FIR - Shu, Francy
IR  - Oskoui M
FIR - Oskoui, Maryam
IR  - Zielinski D
FIR - Zielinski, David
IR  - Poulin C
FIR - Poulin, Chantal
IR  - Ingelmo PM
FIR - Ingelmo, Pablo Mauricio
IR  - Desilets ST
FIR - Desilets, Sarah Turgeon
IR  - Dinunzio P
FIR - Dinunzio, Pamela
IR  - Rivera G
FIR - Rivera, Gonzalo
IR  - Srour M
FIR - Srour, Myriam
IR  - Arpin S
FIR - Arpin, Stephanie
IR  - Goobie S
FIR - Goobie, Sharan
IR  - Gibson P
FIR - Gibson, Paul
IR  - Scholtes C
FIR - Scholtes, Cheryl
IR  - McDonald W
FIR - McDonald, Wendy
IR  - Zapata E
FIR - Zapata, Eugenio
IR  - Nguyen CE
FIR - Nguyen, Cam-Tu Emilie
IR  - Servais L
FIR - Servais, Laurent
IR  - Gargaun E
FIR - Gargaun, Elena
IR  - Le Moing AG
FIR - Le Moing, Anne-Gaelle
IR  - Gidaro T
FIR - Gidaro, Teresa
IR  - Vialle R
FIR - Vialle, Raphael
IR  - Guye ML
FIR - Guye, Marie-Laurence
IR  - Lilien C
FIR - Lilien, Charlotte
IR  - Olliver G
FIR - Olliver, Gwenn
IR  - Gilabert S
FIR - Gilabert, Stephanie
IR  - Borell S
FIR - Borell, Sabine
IR  - Wider S
FIR - Wider, Sabine
IR  - Stein S
FIR - Stein, Sabine
IR  - Vogt S
FIR - Vogt, Sibylle
IR  - Kruger M
FIR - Kruger, Marcus
IR  - Pechmann A
FIR - Pechmann, Astrid
IR  - Rippberger B
FIR - Rippberger, Bianca
IR  - Eckenweiler M
FIR - Eckenweiler, Matthias
IR  - Schara U
FIR - Schara, Ulrike
IR  - Koelbel H
FIR - Koelbel, Heike
IR  - Andres B
FIR - Andres, Barbara
IR  - Rupprich K
FIR - Rupprich, Katrin
IR  - Gangfuss A
FIR - Gangfuss, Andrea
IR  - Jachertz P
FIR - Jachertz, Philipp
IR  - Della Marina A
FIR - Della Marina, Adela
IR  - Sponemann N
FIR - Sponemann, Nina
IR  - Pane M
FIR - Pane, Markia
IR  - Palermo C
FIR - Palermo, Concetta
IR  - Piastra M
FIR - Piastra, Marco
IR  - Fanelli L
FIR - Fanelli, Lavinia
IR  - De Sanctis R
FIR - De Sanctis, Roberto
IR  - Genovese O
FIR - Genovese, Orazio
IR  - Antonaci L
FIR - Antonaci, Laura
IR  - Pera MC
FIR - Pera, Maria Carmela
IR  - Lamendola P
FIR - Lamendola, Priscilla
IR  - Messina S
FIR - Messina, Sonia
IR  - Vita G
FIR - Vita, Gianluca
IR  - Di Bella V
FIR - Di Bella, Vincenzo
IR  - Sframeli M
FIR - Sframeli, Maria
IR  - la Rosa M
FIR - la Rosa, Matteo
IR  - Barcellona C
FIR - Barcellona, Costanza
IR  - Distefano MG
FIR - Distefano, Maria Grazia
IR  - Cavallaro F
FIR - Cavallaro, Filippo
IR  - Versaci A
FIR - Versaci, Antonio
IR  - De Luca F
FIR - De Luca, Francesco
IR  - Vita G
FIR - Vita, Giuseppe
IR  - Nacimento Osorio A
FIR - Nacimento Osorio, Andres
IR  - Tizzano E
FIR - Tizzano, Eduardo
IR  - Ortez Gonzalez CI
FIR - Ortez Gonzalez, Carlos Ignacio
IR  - Ortigoza Escobar JD
FIR - Ortigoza Escobar, Juan Dario
IR  - Colomer Oferil J
FIR - Colomer Oferil, Juame
IR  - Medina Cantillo J
FIR - Medina Cantillo, Julita
IR  - Rotger AF
FIR - Rotger, Anna Febrer
IR  - Vigo Morancho M
FIR - Vigo Morancho, Meritxell
IR  - Eldblom J
FIR - Eldblom, Johanneh
IR  - Darin N
FIR - Darin, Niklas
IR  - Kroksmark AK
FIR - Kroksmark, Anna Karin
IR  - Lindstedt A
FIR - Lindstedt, Asa
IR  - Michael E
FIR - Michael, Eva
IR  - Kimber E
FIR - Kimber, Eva
IR  - Wahlgren L
FIR - Wahlgren, Lisa
IR  - Chan SH
FIR - Chan, Sophelia Hoi-Shan
IR  - Chim S
FIR - Chim, Stella
IR  - Chiu J
FIR - Chiu, Joseph
IR  - Ho ACC
FIR - Ho, Alvin Chi Chung
IR  - Ip JKJ
FIR - Ip, Jing Kun Janice
IR  - Lam WWM
FIR - Lam, Wendy Wai Man
IR  - Ng MC
FIR - Ng, Maggie Chui-San
IR  - Wan C
FIR - Wan, Connie
IR  - Wong VCN
FIR - Wong, Virginia Chun Nei
IR  - Yue Y
FIR - Yue, Yvonne
IR  - Arakawa R
FIR - Arakawa, Reiko
IR  - Yamauchi A
FIR - Yamauchi, Akemi
IR  - Nagata S
FIR - Nagata, Satoru
IR  - Ito Y
FIR - Ito, Yasushi
IR  - Nakatsukasa H
FIR - Nakatsukasa, Hidetsugu
IR  - Takeshita A
FIR - Takeshita, Akiko
IR  - Hirasawa K
FIR - Hirasawa, Kyoko
IR  - Ikai T
FIR - Ikai, Tetsuo
IR  - Eto K
FIR - Eto, Kaoru
IR  - Otamni Y
FIR - Otamni, Yui
IR  - Takeshima Y
FIR - Takeshima, Yasuhiro
IR  - Fukuda N
FIR - Fukuda, Noroki
IR  - Tanaka Y
FIR - Tanaka, Yasuhiro
IR  - Shimomura H
FIR - Shimomura, Hideki
IR  - Lee T
FIR - Lee, Tomoko
IR  - Shibano T
FIR - Shibano, Takayuki
IR  - Tachikawa T
FIR - Tachikawa, Tomohiro
IR  - Chae JH
FIR - Chae, Jong-Hee
IR  - Lim BC
FIR - Lim, Byung Chan
IR  - Shin HI
FIR - Shin, Hyung-Ik
IR  - Kim SY
FIR - Kim, Soo Yeon
IR  - Choi SA
FIR - Choi, Sun Ah
IR  - Son WS
FIR - Son, Woo Sung
IR  - Jo H
FIR - Jo, Hyemi
IR  - Chun SM
FIR - Chun, Seong Min
IR  - Kim H
FIR - Kim, Hyuna
EDAT- 2018/02/15 06:00
MHDA- 2018/02/21 06:00
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [entrez]
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
AID - 10.1056/NEJMoa1710504 [doi]
PST - ppublish
SO  - N Engl J Med. 2018 Feb 15;378(7):625-635. doi: 10.1056/NEJMoa1710504.