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Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma endothelial cells via downregulation of MCL-1 and HIF-1α.

Abstract Curcumin has been used as an alternative medicine for the treatment of infantile hemangiomas (IHs); however, the mechanism underlying the effectiveness of curcumin in IHs remains largely unclear.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29443732
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20180222
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 7
DP  - 2018 Feb
TI  - Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma
      endothelial cells via downregulation of MCL-1 and HIF-1alpha.
PG  - e9562
LID - 10.1097/MD.0000000000009562 [doi]
AB  - BACKGROUND: Curcumin has been used as an alternative medicine for the treatment
      of infantile hemangiomas (IHs); however, the mechanism underlying the
      effectiveness of curcumin in IHs remains largely unclear. METHODS: In this study,
      we isolated primary human hemangioma endothelial cells (HemECs) from fresh
      surgical specimens of 3 patients. We treated HemECs by curcumin and investigated 
      the alterations in proliferative and apoptotic signaling pathways with cell
      counting kit-8, flow cytometry, western blotting, immunofluorescence, and
      real-time polymerase chain reaction. RESULTS AND CONCLUSION: We found that
      curcumin potently inhibited proliferation in HemECs, achieving low-micromolar
      IC50 (the half maximal inhibitory concentration) value. We also observed that
      treatment with curcumin induced apoptosis in HemECs, as evidenced by positively
      Annexin-V-FITC staining, caspase-3 activation, and cleavage of poly(adenosine
      diphosphate-ribose) polymerase (PARP) in the treated cells. Moreover, we showed
      that curcumin suppressed the expression of antiapoptotic protein myeloid cell
      leukemia-1 (MCL-1), hypoxia-inducible factor 1alpha (HIF-1alpha), and vascular
      endothelial growth factor (VEGF).Altogether, our study suggests that the
      effectiveness of curcumin in IHs may be associated with its potent
      antiproliferative and apoptotic activities in HemECs.
FAU - Lou, Suhui
AU  - Lou S
AD  - Department of Pharmacology.
FAU - Wang, Yanfang
AU  - Wang Y
AD  - Department of Pharmacology.
FAU - Yu, Zujiang
AU  - Yu Z
AD  - Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou
      University, Zhengzhou, Henan Province, China.
FAU - Guan, Kelei
AU  - Guan K
AD  - Department of Pharmacology.
FAU - Kan, Quancheng
AU  - Kan Q
AD  - Department of Pharmacology.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antineoplastic Agents)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (MCL1 protein, human)
RN  - 0 (Myeloid Cell Leukemia Sequence 1 Protein)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - IT942ZTH98 (Curcumin)
RN  - Hemangioma, capillary infantile
SB  - AIM
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis/drug effects
MH  - Cell Proliferation/drug effects
MH  - Child, Preschool
MH  - Curcumin/*pharmacology
MH  - Down-Regulation
MH  - Endothelial Cells/drug effects
MH  - Hemangioma, Capillary/*drug therapy/genetics
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*drug effects/metabolism
MH  - Male
MH  - Myeloid Cell Leukemia Sequence 1 Protein/*drug effects/metabolism
MH  - Neoplastic Syndromes, Hereditary/*drug therapy/genetics
MH  - Signal Transduction/drug effects
MH  - Vascular Endothelial Growth Factor A/drug effects/metabolism
EDAT- 2018/02/15 06:00
MHDA- 2018/02/23 06:00
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [entrez]
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
AID - 10.1097/MD.0000000000009562 [doi]
AID - 00005792-201802160-00006 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Feb;97(7):e9562. doi: 10.1097/MD.0000000000009562.