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Hodgkin lymphoma involving the tonsil misdiagnosed as tonsillar carcinoma: A case report and review of the literature.

Abstract Primary Hodgkin lymphoma (HL) involving the tonsil is extremely rare. Only about 20 such cases with verification of biopsy and immunohistochemistry have been reported. Because of its rarity and unremarkable clinical presentation, a timely correct diagnosis is very challenging.
PMID
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Authors

Mayor MeshTerms

Diagnostic Errors

Keywords
Journal Title medicine
Publication Year Start




PMID- 29443738
OWN - NLM
STAT- MEDLINE
DCOM- 20180222
LR  - 20180222
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 7
DP  - 2018 Feb
TI  - Hodgkin lymphoma involving the tonsil misdiagnosed as tonsillar carcinoma: A case
      report and review of the literature.
PG  - e9761
LID - 10.1097/MD.0000000000009761 [doi]
AB  - RATIONALE: Primary Hodgkin lymphoma (HL) involving the tonsil is extremely rare. 
      Only about 20 such cases with verification of biopsy and immunohistochemistry
      have been reported. Because of its rarity and unremarkable clinical presentation,
      a timely correct diagnosis is very challenging. PATIENT CONCERNS: A 43-year-old
      man complained left tonsillar enlargement and painless masses in left neck, with 
      night sweat. The clinical examination found a marked tonsillar asymmetry, with an
      enlarged left tonsil and ipsilateral cervical lymphadenopathy and a normal right 
      tonsil. DIAGNOSIS: The patient was initially regarded as tonsillar
      lymphoepithelial carcinoma. INTERVENTIONS: The patient received a resection of
      left tonsil and left cervical masses and then was definitively diagnosed as HL
      (IIEB). He was managed by 6 cycles of chemotherapy (adriamycin, bleomycin,
      vinblastine, and dacarbazine) and radiotherapy to the Waldeyer ring. OUTCOMES:
      The patient has been disease free for more than 3 years after diagnosis. LESSONS:
      As the reason of an extreme rare occurrence of HL involving the tonsil, doctors
      can easily misdiagnose the disease as tonsillar lymphoepithelial carcinoma. This 
      case serves as a reminder important role of biopsy.
FAU - Qin, You
AU  - Qin Y
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of
      Science and Technology, Wuhan.
FAU - Lu, Lijuan
AU  - Lu L
AD  - Department of Molecular Medicine, Zhongshan School of Medicine, Sun Yat-Sen
      University, Guangzhou, Guangdong, China.
FAU - Lu, Yanwei
AU  - Lu Y
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of
      Science and Technology, Wuhan.
FAU - Yang, Kunyu
AU  - Yang K
AD  - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of
      Science and Technology, Wuhan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - Carcinoma/*diagnosis
MH  - *Diagnostic Errors
MH  - Hodgkin Disease/*diagnosis/drug therapy
MH  - Humans
MH  - Male
MH  - Palatine Tonsil/pathology/surgery
MH  - Tonsillar Neoplasms/*diagnosis/drug therapy
EDAT- 2018/02/15 06:00
MHDA- 2018/02/23 06:00
CRDT- 2018/02/15 06:00
PHST- 2018/02/15 06:00 [entrez]
PHST- 2018/02/15 06:00 [pubmed]
PHST- 2018/02/23 06:00 [medline]
AID - 10.1097/MD.0000000000009761 [doi]
AID - 00005792-201802160-00012 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Feb;97(7):e9761. doi: 10.1097/MD.0000000000009761.