PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 29491098
OWN - NLM
STAT- MEDLINE
DCOM- 20180312
LR  - 20180312
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 38
IP  - 3
DP  - 2018 Mar
TI  - National Practice Patterns for Clinical T1N0 Nasopharyngeal Cancer in the
      Elderly: A National Cancer Data Base Analysis.
PG  - 1651-1657
AB  - BACKGROUND: The standard of care for T1N0 nasopharyngeal cancer (NPC) is
      definitive radiation therapy (RT). However, practice patterns in the elderly may 
      not necessarily follow national guidelines. Herein, we investigated national
      practice patterns for T1N0 NPC. MATERIALS AND METHODS: The National Cancer Data
      Base (NCDB) was queried for clinical T1N0 primary NPC cases (2004-2013) in
      patients >/=70 years old. Patient, tumor, and treatment parameters were
      extracted. Kaplan-Meier analysis was used to compare overall survival (OS)
      between patients receiving RT versus those under observation. Logistic regression
      was used to examine variables associated with receipt of RT. Cox proportional
      hazards modeling determined variables associated with OS. Landmark analysis of
      patients surviving 1 year or more was performed to assess survival differences
      between groups. RESULTS: In total, data of 147 patients were analyzed. RT was
      delivered to 89 patients (61%), whereas 58 (39%) patients underwent observation. 
      On multivariable analysis, older patients were less likely to receive RT
      (p=0.003), but there were no differences between groups in terms of Charlson-Deyo
      comorbidity index. Median and 5-year OS in patients receiving RT versus those
      under observation were 71 and 33 months, and 59% and 48% (p=0.011), respectively.
      For patients surviving 1 year or more (n=96), there was a strong trend showing
      that receipt of RT was associated with better median and 5-year OS. CONCLUSION:
      This National Data Base analysis shows that observation is relatively common for 
      T1N0 NPC in the elderly, but is associated with poorer survival.
CI  - Copyright(c) 2018, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Post, Carl M
AU  - Post CM
AD  - Department of Radiation Oncology, University of Nebraska Medical Center, Omaha,
      NE, U.S.A.
FAU - Lin, Chi
AU  - Lin C
AD  - Department of Radiation Oncology, University of Nebraska Medical Center, Omaha,
      NE, U.S.A.
FAU - Adeberg, Sebastian
AU  - Adeberg S
AD  - Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg,
      Germany.
FAU - Gupta, Mrigank
AU  - Gupta M
AD  - School of Medicine, University of Missouri Kansas City, Kansas City, MO, U.S.A.
FAU - Zhen, Weining
AU  - Zhen W
AD  - Department of Radiation Oncology, University of Nebraska Medical Center, Omaha,
      NE, U.S.A.
FAU - Verma, Vivek
AU  - Verma V
AD  - Department of Radiation Oncology, University of Nebraska Medical Center, Omaha,
      NE, U.S.A. [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Databases, Factual/*statistics & numerical data
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - Nasopharyngeal Neoplasms/pathology/*radiotherapy
MH  - Proportional Hazards Models
MH  - United States
OTO - NOTNLM
OT  - *Nasopharyngeal cancer
OT  - *nasopharynx
OT  - *observation
OT  - *radiation therapy
OT  - *survival
EDAT- 2018/03/02 06:00
MHDA- 2018/03/13 06:00
CRDT- 2018/03/02 06:00
PHST- 2017/12/21 00:00 [received]
PHST- 2018/01/28 00:00 [revised]
PHST- 2018/01/30 00:00 [accepted]
PHST- 2018/03/02 06:00 [entrez]
PHST- 2018/03/02 06:00 [pubmed]
PHST- 2018/03/13 06:00 [medline]
AID - 38/3/1651 [pii]
AID - 10.21873/anticanres.12397 [doi]
PST - ppublish
SO  - Anticancer Res. 2018 Mar;38(3):1651-1657. doi: 10.21873/anticanres.12397.