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Association between serum 25-hydroxyvitamin D concentration and pulmonary infection in children.

Abstract We assessed the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and community-acquired pneumonia (CAP) among Chinese children.This observational study examined children aged 3 days to 14 years (n = 1582) from the Capital Institute of Pediatrics in 2009 to 2011. There were 797 children in the CAP group and 785 controls. The CAP group was divided into 2 groups: a pneumonia group and pneumonia-induced sepsis group. The serum 25(OH)D level was estimated using micro whole blood chemiluminescence.The average serum 25(OH)D level in all samples was 25.32 ± 14.07 ng/mL, with the CAP group showing a lower value than the control group (P < .001). There were also significant differences between the pneumonia group and pneumonia-induced sepsis group (P < .001). In the pneumonia-induced sepsis group, significant differences in serum 25(OH)D levels were observed in children who received mechanical ventilation or presenting with multiple organ dysfunction (P < .01).All serum 25(OH)D levels in the pneumonia group and pneumonia-induced sepsis group were below normal levels, particularly in the sepsis group. A lower serum 25(OH)D level was associated with more serious symptoms in CAP children. Children with low serum 25(OH)D levels may be at higher risk of receiving mechanical ventilation and presenting with multiple organ dysfunction. These findings suggest that vitamin D supplements are beneficial for the treatment and prevention of CAP.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29505508
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180309
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 1
DP  - 2018 Jan
TI  - Association between serum 25-hydroxyvitamin D concentration and pulmonary
      infection in children.
PG  - e9060
LID - 10.1097/MD.0000000000009060 [doi]
AB  - We assessed the relationship between serum 25-hydroxyvitamin D (25(OH)D) level
      and community-acquired pneumonia (CAP) among Chinese children.This observational 
      study examined children aged 3 days to 14 years (n = 1582) from the Capital
      Institute of Pediatrics in 2009 to 2011. There were 797 children in the CAP group
      and 785 controls. The CAP group was divided into 2 groups: a pneumonia group and 
      pneumonia-induced sepsis group. The serum 25(OH)D level was estimated using micro
      whole blood chemiluminescence.The average serum 25(OH)D level in all samples was 
      25.32 +/- 14.07 ng/mL, with the CAP group showing a lower value than the control 
      group (P &lt; .001). There were also significant differences between the pneumonia
      group and pneumonia-induced sepsis group (P &lt; .001). In the pneumonia-induced
      sepsis group, significant differences in serum 25(OH)D levels were observed in
      children who received mechanical ventilation or presenting with multiple organ
      dysfunction (P &lt; .01).All serum 25(OH)D levels in the pneumonia group and
      pneumonia-induced sepsis group were below normal levels, particularly in the
      sepsis group. A lower serum 25(OH)D level was associated with more serious
      symptoms in CAP children. Children with low serum 25(OH)D levels may be at higher
      risk of receiving mechanical ventilation and presenting with multiple organ
      dysfunction. These findings suggest that vitamin D supplements are beneficial for
      the treatment and prevention of CAP.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Li, Wei
AU  - Li W
AD  - Department of ICU, Affiliated Children's Hospital of Capital Institute of
      Pediatrics.
FAU - Cheng, Xianfen
AU  - Cheng X
AD  - Department of Central Laboratory of Capital Institute of Pediatrics.
FAU - Guo, Linying
AU  - Guo L
AD  - Department of ICU, Affiliated Children's Hospital of Capital Institute of
      Pediatrics.
FAU - Li, Hongri
AU  - Li H
AD  - Department of ICU, Affiliated Children's Hospital of Capital Institute of
      Pediatrics.
FAU - Sun, Chunrong
AU  - Sun C
AD  - Department of Central Laboratory of Capital Institute of Pediatrics.
FAU - Cui, Xiaodai
AU  - Cui X
AD  - Department of Central Laboratory of Capital Institute of Pediatrics.
FAU - Zhang, Qi
AU  - Zhang Q
AD  - Department of Pediatrics, China-Japan Friendship Hospital District, Chaoyang
      District, Beijing, China.
FAU - Song, Guowei
AU  - Song G
AD  - Department of Central Laboratory of Capital Institute of Pediatrics.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 1406-16-2 (Vitamin D)
RN  - 64719-49-9 (25-hydroxyvitamin D)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Community-Acquired Infections/blood/etiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Nutritional Status
MH  - Pneumonia/*blood/etiology
MH  - ROC Curve
MH  - Seasons
MH  - Sepsis/blood/etiology
MH  - Vitamin D/*analogs &amp; derivatives/blood
MH  - Vitamin D Deficiency/*complications
EDAT- 2018/03/06 06:00
MHDA- 2018/03/10 06:00
CRDT- 2018/03/06 06:00
PHST- 2018/03/06 06:00 [entrez]
PHST- 2018/03/06 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - 10.1097/MD.0000000000009060 [doi]
AID - 00005792-201801050-00005 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jan;97(1):e9060. doi: 10.1097/MD.0000000000009060.