PubTransformer

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PMID- 29505528
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180309
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 1
DP  - 2018 Jan
TI  - Recombinant human erythropoietin for treating severe traumatic brain injury.
PG  - e9532
LID - 10.1097/MD.0000000000009532 [doi]
AB  - BACKGROUND: This study aimed to explore the efficacy and safety of recombinant
      human erythropoietin (RHE) for the treatment of severe traumatic brain injury
      (STBI). METHODS: One hundred and twenty eligible patients with STBI were randomly
      divided into an intervention group or a control group equally. Patients in the
      intervention group received RHE. The participants in the control group received
      0.9% saline. The outcome measurements included the Glasgow Outcome Scale (GOS)
      scores, mortality, and any adverse events. RESULTS: At the end of 10-week
      follow-up after treatment, RHE neither showed greater efficacy in GOS scores
      (1-2, P = .43; 3-4, P = .25; 5-6, P = .58; 7-8, P = .23), nor the lower mortality
      in the intervention group than those in the control group (P = .47). In addition,
      both groups had similar safety profile. CONCLUSION: This study found that RHE did
      not improve the neurological outcomes in patients with STBI.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Bai, Xiao-Fei
AU  - Bai XF
AD  - Department of Neurosurgery, The People's Hospital of Yan'an, Yan'an, Shaanxi,
      China.
FAU - Gao, Yong-Kai
AU  - Gao YK
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Recombinant Proteins)
RN  - 11096-26-7 (Erythropoietin)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Brain Injuries, Traumatic/*drug therapy
MH  - Erythropoietin/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Recombinant Proteins/therapeutic use
EDAT- 2018/03/06 06:00
MHDA- 2018/03/10 06:00
CRDT- 2018/03/06 06:00
PHST- 2018/03/06 06:00 [entrez]
PHST- 2018/03/06 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - 10.1097/MD.0000000000009532 [doi]
AID - 00005792-201801050-00025 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jan;97(1):e9532. doi: 10.1097/MD.0000000000009532.