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High EMP3 expression might independently predict poor overall survival in glioblastoma and its expression is related to DNA methylation.

Abstract In this study, we analyzed the prognostic value of epithelial membrane protein 3 (EMP3) in terms of overall survival (OS) in glioblastoma multiforme (GBM) and the association between its expression and DNA methylation.Bioinformatic analysis was performed by using data from the Cancer Genome Atlas (TCGA) database.EMP3 expression was markedly higher in GBM tissues than in normal brain tissues. High EMP3 expression was associated with significantly worse OS in patients with GBM. Univariate and multivariate analysis showed that EMP3 expression was an independent prognostic factor of poor OS no matter converting its expression into categorical variables (Hazard Ratio [HR] = 1.359, 95%CI: 1.118-1.652, P = .002) or setting it as a continuous variable (HR = 1.178, 95%CI: 1.101-1.260, P < .001). Among different subtypes of GBM, proneural subtype had the lowest EMP3 expression. The lowest EMP3 expression was observed in cluster 5 DNA methylation, which all belong to G-CIMP phenotype. Regression analysis confirmed a moderate negative correlation between EMP3 expression and its DNA methylation (Pearson's r = -0.61).Based on these findings, we infer that high EMP3 expression might be an independent indicator of unfavorable OS in GBM. EMP3 expression might be repressed by DNA methylation.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29505529
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180309
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 1
DP  - 2018 Jan
TI  - High EMP3 expression might independently predict poor overall survival in
      glioblastoma and its expression is related to DNA methylation.
PG  - e9538
LID - 10.1097/MD.0000000000009538 [doi]
AB  - In this study, we analyzed the prognostic value of epithelial membrane protein 3 
      (EMP3) in terms of overall survival (OS) in glioblastoma multiforme (GBM) and the
      association between its expression and DNA methylation.Bioinformatic analysis was
      performed by using data from the Cancer Genome Atlas (TCGA) database.EMP3
      expression was markedly higher in GBM tissues than in normal brain tissues. High 
      EMP3 expression was associated with significantly worse OS in patients with GBM. 
      Univariate and multivariate analysis showed that EMP3 expression was an
      independent prognostic factor of poor OS no matter converting its expression into
      categorical variables (Hazard Ratio [HR] = 1.359, 95%CI: 1.118-1.652, P = .002)
      or setting it as a continuous variable (HR = 1.178, 95%CI: 1.101-1.260, P &lt;
      .001). Among different subtypes of GBM, proneural subtype had the lowest EMP3
      expression. The lowest EMP3 expression was observed in cluster 5 DNA methylation,
      which all belong to G-CIMP phenotype. Regression analysis confirmed a moderate
      negative correlation between EMP3 expression and its DNA methylation (Pearson's r
      = -0.61).Based on these findings, we infer that high EMP3 expression might be an 
      independent indicator of unfavorable OS in GBM. EMP3 expression might be
      repressed by DNA methylation.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Yue, Hongsheng
AU  - Yue H
AD  - Department of Neurosurgery, Jinan Central Hospital Affiliated to Shandong
      University, Jinan.
FAU - Xu, Qun
AU  - Xu Q
AD  - Nursing Department, Jinan Vocational College of Nursing.
FAU - Xie, Shugang
AU  - Xie S
AD  - Department of Neurosurgery, Shanghe County People's Hospital, Jinan, Shandong,
      251600, China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (EMP3 protein, human)
RN  - 0 (Membrane Glycoproteins)
SB  - AIM
SB  - IM
MH  - Aged
MH  - Brain Neoplasms/*metabolism/mortality
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - CpG Islands
MH  - DNA Methylation
MH  - Female
MH  - Glioblastoma/*metabolism/mortality
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - Middle Aged
EDAT- 2018/03/06 06:00
MHDA- 2018/03/10 06:00
CRDT- 2018/03/06 06:00
PHST- 2018/03/06 06:00 [entrez]
PHST- 2018/03/06 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - 10.1097/MD.0000000000009538 [doi]
AID - 00005792-201801050-00026 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jan;97(1):e9538. doi: 10.1097/MD.0000000000009538.