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Case report of a pituitary thyrotropin-secreting macroadenoma with Hashimoto thyroiditis and infertility.

Abstract Thyrotropin-secreting adenoma (TSHoma) is rare, diagnosis and treatment are often delayed if the condition coexists with Hashimoto thyroiditis. The enlarged pituitary adenoma may eventually induce panhypopituitarism, infertility, or the compression of optic nerves and optic chiasma.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29505532
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180309
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 1
DP  - 2018 Jan
TI  - Case report of a pituitary thyrotropin-secreting macroadenoma with Hashimoto
      thyroiditis and infertility.
PG  - e9546
LID - 10.1097/MD.0000000000009546 [doi]
AB  - RATIONALE: Thyrotropin-secreting adenoma (TSHoma) is rare, diagnosis and
      treatment are often delayed if the condition coexists with Hashimoto thyroiditis.
      The enlarged pituitary adenoma may eventually induce panhypopituitarism,
      infertility, or the compression of optic nerves and optic chiasma. PATIENT
      CONCERNS: This patient was a 36-year-old man who had been referred to the
      pituitary disease multidisciplinary team (MDT) of the West China Hospital, due to
      infertility. DIAGNOSES: Examinations revealed pituitary thyrotropin-secreting
      macroadenoma. INTERVENTIONS: We conducted trans-sphenoidal surgery. Human
      chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) were used
      for reproductive reconstruction after surgery. OUTCOMES: This patient
      successfully fathered a child. LESSONS: To date, the multidisciplinary team
      treatment of TSHoma was rare, TSHomas are often misdiagnosed as macroadenomas,
      because the clinical features are varied and it often takes a long time to be
      diagnosed. So the purpose of this case report is to attract attention to the
      manifestation of increased thyroid stimulating hormone (TSH) concentration and
      discuss MDT treatment for TSH-secreting adenoma.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Li, Jiaqi
AU  - Li J
AD  - Department of Endocrinology and Metabolism.
FAU - Li, Jianwei
AU  - Li J
AD  - Department of Endocrinology and Metabolism.
FAU - Jiang, Shu
AU  - Jiang S
AD  - Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu,
      Sichuan Province, China.
FAU - Yu, Ruichao
AU  - Yu R
AD  - Department of Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center,
      Harvard Medical School, Boston, Massachusetts.
FAU - Yu, Yerong
AU  - Yu Y
AD  - Department of Endocrinology and Metabolism.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 9002-71-5 (Thyrotropin)
SB  - AIM
SB  - IM
MH  - Adenoma/*complications/diagnosis/secretion/surgery
MH  - Adult
MH  - Female
MH  - Hashimoto Disease/*complications
MH  - Humans
MH  - Infertility, Male/*etiology/therapy
MH  - Male
MH  - Pituitary Neoplasms/*complications/diagnosis/secretion/surgery
MH  - Pregnancy
MH  - Thyrotropin/*secretion
EDAT- 2018/03/06 06:00
MHDA- 2018/03/10 06:00
CRDT- 2018/03/06 06:00
PHST- 2018/03/06 06:00 [entrez]
PHST- 2018/03/06 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - 10.1097/MD.0000000000009546 [doi]
AID - 00005792-201801050-00029 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jan;97(1):e9546. doi: 10.1097/MD.0000000000009546.