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Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A retrospective study.

Abstract In acute carbon monoxide (CO) intoxication, treatment of neurologic injury and prevention of neurological sequelae are primary concerns. Ethanol is the one of the frequent substances which is co-ingested in intentional CO poisoning. Neuroprotective effect of ethanol was highlighted and demonstrated in isolated brain injury recently. We assessed the neuroprotective effect of ethanol in acute CO intoxication using magnetic resonance imaging (MRI).We retrospectively reviewed medical records for patients who visited an emergency medical center of a university-affiliated hospital during a period of 73 months, from March 2009 to April 2015. Enrolled patients were divided into 2 groups, patients with or without abnormal brain lesion in brain MRI. Multivariate logistic regression analysis was performed to assess the factors associated with brain injury in MRI.A total of 109 patients with acute CO intoxication were evaluated of which 66 (60.55%) tested positive in brain MRI. MRI lesion-positive patients were more likely to have electrocardiogram change, elevation of serum troponin I and s100 protein level and lower serum ethanol level. Serum ethanol positivity was an independent factor for prevalence of brain injury in MRI in acute CO poisoning.This study revealed that ethanol which is co-ingested in acute CO intoxication may work the neuroprotective effect and could consequence more favorable neurological outcome in acute CO intoxication.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29505539
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180309
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 1
DP  - 2018 Jan
TI  - Neuroprotective effect of ethanol in acute carbon monoxide intoxication: A
      retrospective study.
PG  - e9569
LID - 10.1097/MD.0000000000009569 [doi]
AB  - In acute carbon monoxide (CO) intoxication, treatment of neurologic injury and
      prevention of neurological sequelae are primary concerns. Ethanol is the one of
      the frequent substances which is co-ingested in intentional CO poisoning.
      Neuroprotective effect of ethanol was highlighted and demonstrated in isolated
      brain injury recently. We assessed the neuroprotective effect of ethanol in acute
      CO intoxication using magnetic resonance imaging (MRI).We retrospectively
      reviewed medical records for patients who visited an emergency medical center of 
      a university-affiliated hospital during a period of 73 months, from March 2009 to
      April 2015. Enrolled patients were divided into 2 groups, patients with or
      without abnormal brain lesion in brain MRI. Multivariate logistic regression
      analysis was performed to assess the factors associated with brain injury in
      MRI.A total of 109 patients with acute CO intoxication were evaluated of which 66
      (60.55%) tested positive in brain MRI. MRI lesion-positive patients were more
      likely to have electrocardiogram change, elevation of serum troponin I and s100
      protein level and lower serum ethanol level. Serum ethanol positivity was an
      independent factor for prevalence of brain injury in MRI in acute CO
      poisoning.This study revealed that ethanol which is co-ingested in acute CO
      intoxication may work the neuroprotective effect and could consequence more
      favorable neurological outcome in acute CO intoxication.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Kim, Hyuk-Hoon
AU  - Kim HH
AD  - Department of Emergency Medicine, Ajou University School of Medicine, Suwon,
      Republic of Korea.
FAU - Choi, Sang Chun
AU  - Choi SC
FAU - Chae, Minjung Kathy
AU  - Chae MK
FAU - Min, Young-Gi
AU  - Min YG
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Central Nervous System Depressants)
RN  - 3K9958V90M (Ethanol)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain/diagnostic imaging/*drug effects
MH  - Brain Injuries/blood/diagnostic imaging/*etiology/prevention & control
MH  - Carbon Monoxide Poisoning/blood/*complications/diagnostic imaging
MH  - Central Nervous System Depressants/blood/*pharmacology
MH  - Ethanol/blood/*pharmacology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2018/03/06 06:00
MHDA- 2018/03/10 06:00
CRDT- 2018/03/06 06:00
PHST- 2018/03/06 06:00 [entrez]
PHST- 2018/03/06 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - 10.1097/MD.0000000000009569 [doi]
AID - 00005792-201801050-00036 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jan;97(1):e9569. doi: 10.1097/MD.0000000000009569.