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The clinical manifestation, survival outcome and predictive prognostic factors of 137 patients with primary gastrointestinal lymphoma (PGIL): Strobe compliant.

Abstract This retrospective study aimed to investigate clinical characteristics and prognostic factors in patients with primary gastrointestinal lymphoma (PGIL) of Chinese population.From January 2001 to December 2015, 137 patients diagnosed with PGIL were recruited. The clinical features, treatment, and follow-up information were analysed.The median patient age was 62.3 years. With 18.47 months follow-up, the 2-year progress-free survival and overall survival rate was 74.9% and 75.5%, respectively. The overall response rate was 33.6%. Age≥60 years, advanced Lugano staging (≥stage IIE), elevated lactate dehydrogenase (LDH) levels, ≥2 extra-nodal involved sites, National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI)≥4, Ki-67≥50% were associated with worse prognosis in univariate analysis (P < .05). By multivariate analyses, we determined that the involvement of extra-nodal involved sites was the only statistically significant poor prognostic factor in PGIL.Age, staging, LDH levels, NCCN-IPI, Ki-67 especially involvement of multiple extra-nodal sites were associated with poor overall survival of PGIL.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 29505542
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180309
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 1
DP  - 2018 Jan
TI  - The clinical manifestation, survival outcome and predictive prognostic factors of
      137 patients with primary gastrointestinal lymphoma (PGIL): Strobe compliant.
PG  - e9583
LID - 10.1097/MD.0000000000009583 [doi]
AB  - This retrospective study aimed to investigate clinical characteristics and
      prognostic factors in patients with primary gastrointestinal lymphoma (PGIL) of
      Chinese population.From January 2001 to December 2015, 137 patients diagnosed
      with PGIL were recruited. The clinical features, treatment, and follow-up
      information were analysed.The median patient age was 62.3 years. With 18.47
      months follow-up, the 2-year progress-free survival and overall survival rate was
      74.9% and 75.5%, respectively. The overall response rate was 33.6%. Age&gt;/=60
      years, advanced Lugano staging (&gt;/=stage IIE), elevated lactate dehydrogenase
      (LDH) levels, &gt;/=2 extra-nodal involved sites, National Comprehensive Cancer
      Network International Prognostic Index (NCCN-IPI)&gt;/=4, Ki-67&gt;/=50% were
      associated with worse prognosis in univariate analysis (P &lt; .05). By multivariate
      analyses, we determined that the involvement of extra-nodal involved sites was
      the only statistically significant poor prognostic factor in PGIL.Age, staging,
      LDH levels, NCCN-IPI, Ki-67 especially involvement of multiple extra-nodal sites 
      were associated with poor overall survival of PGIL.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All
      rights reserved.
FAU - Shi, Zhan
AU  - Shi Z
AD  - Department of Medical Oncology.
FAU - Ding, Hao
AU  - Ding H
AD  - Department of General Surgery.
FAU - Shen, Qian Wen
AU  - Shen QW
AD  - Department of Radiation Oncology.
FAU - Lu, Xin Gang
AU  - Lu XG
AD  - Department of Traditional Chinese Medicine of Hua'dong Hospital Affiliated to
      Fu'dan University, Shanghai, People's Republic of China.
FAU - Chen, Jia Yan
AU  - Chen JY
AD  - Department of Medical Oncology.
FAU - Chen, Xi
AU  - Chen X
AD  - Department of Medical Oncology.
FAU - Tang, Xi
AU  - Tang X
AD  - Department of Medical Oncology.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Combined Chemotherapy Protocols
MH  - China/epidemiology
MH  - Female
MH  - Gastrointestinal Neoplasms/diagnosis/*mortality/pathology/therapy
MH  - Gastrointestinal Tract/pathology
MH  - Humans
MH  - Lymphoma/diagnosis/*mortality/pathology/therapy
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2018/03/06 06:00
MHDA- 2018/03/10 06:00
CRDT- 2018/03/06 06:00
PHST- 2018/03/06 06:00 [entrez]
PHST- 2018/03/06 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - 10.1097/MD.0000000000009583 [doi]
AID - 00005792-201801050-00039 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Jan;97(1):e9583. doi: 10.1097/MD.0000000000009583.