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PMID- 29506510
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20180309
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 18
IP  - 1
DP  - 2018 Mar 5
TI  - Predictive multi-imaging biomarkers relevant for visual acuity in idiopathic
      macular telangiectasis type 1.
PG  - 69
LID - 10.1186/s12886-018-0737-y [doi]
AB  - BACKGROUND: To evaluate the structural changes associated with visual acuity (VA)
      in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal
      imaging modalities. METHODS: A retrospective study of 14 patients with MT type 1 
      and of 10 eyes from 10 healthy individuals as age-matched controls was conducted.
      The medical records of patients who had undergone colour fundus photography,
      spectral domain optical coherence tomography (OCT), fluorescein angiography and
      OCT angiography were reviewed. Central macular thickness (CMT), the areas of
      macular oedema and ellipsoid zone (EZ) disruption, EZ length, disorganization of 
      the retinal inner layers (DRIL) and external limiting membrane (ELM) disruption, 
      as measured by spectral domain OCT; and vascular density and the foveal avascular
      zones (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus
      (DCP), as measured by OCT angiography, were assessed in MT type 1 eyes and
      correlated with VA. RESULTS: The mean baseline best-corrected VA of MT type 1
      eyes was 0.45 +/- 0.28. The mean CMT was 385.19 +/- 75.21 mum in MT type 1 eyes
      and 252.43 +/- 15.77 mum in contralateral eyes (Z = - 4.113, p < 0.001). The mean
      vessel density of the DCP was lower in MT type 1 eyes (47.25 +/- 4.69%) than in
      contralateral eyes (53.93 +/- 2.94%) and normal eyes (59.37 +/- 2.50%) (Z = -
      3.492, - 4.099; p < 0.001, < 0.001). The baseline logMAR VA was correlated with
      CMT (r = 0.682, p = 0.007), SCP density (r = - 0.652, p = 0.012), DCP density (r 
      = - 0.700, p = 0.005), total area of EZ disruption (r = 0.649, p = 0.012); and
      total lengths of EZ (r = 0.681, p = 0.007), ELM (r = 0.699, p = 0.005) and DRIL
      (r = 0.707, p = 0.005) disruption in the 1-mm-diameter foveal region in MT type 1
      eyes. CONCLUSIONS: Decreased DCP density and the presence of DRIL may be
      predictive biomarkers of VA in MT type 1. CMT, SCP density, total area of EZ
      disruption, and lengths of EZ and ELM disruption within the 1-mm-diameter central
      region were strongly associated with VA.
FAU - Guo, Jingli
AU  - Guo J
AD  - Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai
      Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China.
FAU - Tang, WenYi
AU  - Tang W
AD  - Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai
      Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China.
FAU - Ye, Xiaofeng
AU  - Ye X
AD  - Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai
      Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China.
FAU - Wu, Haixiang
AU  - Wu H
AD  - Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai
      Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China.
FAU - Xu, Gezhi
AU  - Xu G
AD  - Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai
      Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China.
FAU - Liu, Wei
AU  - Liu W
AD  - Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai
      Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China.
      [email protected]
FAU - Zhang, Yongjin
AU  - Zhang Y
AUID- ORCID: http://orcid.org/0000-0002-4058-0658
AD  - Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai
      Key Laboratory of Visual Impairment and Restoration, Shanghai, 200031, China.
      [email protected]
LA  - eng
GR  - 12016116/Shanghai Hospital Development Center
PT  - Journal Article
DEP - 20180305
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - *Computed Tomography Angiography
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Macular Edema/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Retinal Telangiectasis/*diagnostic imaging/physiopathology
MH  - Retinal Vessels/diagnostic imaging
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/*physiology
PMC - PMC5836363
OTO - NOTNLM
OT  - Disorganization of the retinal inner layers
OT  - Ellipsoid zone disruption
OT  - Macular telangiectasia type 1
OT  - Optical coherence tomography angiography
EDAT- 2018/03/07 06:00
MHDA- 2018/03/10 06:00
CRDT- 2018/03/07 06:00
PHST- 2017/10/20 00:00 [received]
PHST- 2018/02/28 00:00 [accepted]
PHST- 2018/03/07 06:00 [entrez]
PHST- 2018/03/07 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
AID - 10.1186/s12886-018-0737-y [doi]
AID - 10.1186/s12886-018-0737-y [pii]
PST - epublish
SO  - BMC Ophthalmol. 2018 Mar 5;18(1):69. doi: 10.1186/s12886-018-0737-y.